Abstract: Ureteral or bladder catheters are provided, including (a) a proximal portion; and (b) a distal portion, the distal portion including a retention portion that includes one or more protected drainage holes, ports or perforations and is configured to establish an outer periphery or protective surface area that inhibits mucosal tissue from occluding the one or more protected drainage holes, ports or perforations upon application of negative pressure through the catheter. Systems, kits and methods for inducing negative pressure to increase renal function also are provided.

Abstract: A fastener, for example a bone screw, is sized to pass into an aperture of an implant, for example, a bone plate, the fastener having an anchor portion engageable with body tissue, and a head portion formed by an assembly of an insert and an anchor extension. The insert and anchor extension cooperate to form a reduced dimension passable into the aperture, and an expanded dimension not passable out of the aperture. The size of the assembly may be configurable, for example, by tabs, ramped surfaces, or an expanding diameter of a threadable insert.

Abstract: A fastener, for example a bone screw, is sized to pass through a hole of an implant, for example a bone plate, the fastener having a shaft or anchor portion engageable with body tissue, and a head portion. A locking cap secures to the bone plate and covers the head to block the head and inhibit screw back out. Alternatively, or additionally, a locking disc located in the plate hole resiliently deflects downward to allow screw insertion, but is blocked to limit or prevent upward deflection so that screw back out is inhibited.

Abstract: The invention encompasses a bone screw for use in the human body including a shaft having a threaded region along at least a portion of its length and a screw head including a locking mechanism to secure the screw, for example to a bone plate. In certain embodiments, the thread has an outer diameter dimensioned to pass through the screw hole in the implant. The screw head is configured to cooperatively engage at least a portion of the screw hole of the implant so as to prevent the screw from coming out of the implant and avoided soft tissue damage and other complications associated with unintended screw removal.

Abstract: A bone stabilizing plate includes two plate portions, each affixable to bones of a patient, the plate portions telescoping together with mating rails and grooves. A limiter associated with one of the plate portions sliding engages one a catch associated with the other of the plate portions, when the plate portions are telescoped together, and resists stops telescoping when the plate portions are telescoped a predetermined distance apart. Once the limiter and catch are engaged, the plate portions enable imposition of a minimum compressive force between bones connected to the plates. The limiter is resiliently positioned to deflect into a relief formed in its respective plate portion. A groove positioned proximate the catch enables free telescoping motion limited by the engagement of the catch and limiter, whereby the minimum compressive force between bones is maintained, and Wolfe's Law may apply.

Abstract: Ureteral catheters and assemblies are provided including: a proximal portion; and a distal portion, the distal portion including a retention portion, wherein the retention portion includes an inwardly facing side including one or more drainage ports and an outwardly facing side, and wherein, when negative pressure is applied through the ureteral catheter, fluid is drawn into the ureteral catheter through the one or more drainage ports while mucosal tissue is prevented from appreciably occluding the one or more drainage ports.

Abstract: A fastener, for example a bone screw, is sized to pass through a hole of an implant, for example a bone plate, the fastener having a shaft or anchor portion engageable with body tissue, and a head portion. A locking cap secures to the bone plate and covers the head to block the head and inhibit screw back out. Alternatively or additionally, a locking disc located in the plate hole resiliently deflects downward to allow screw insertion, but is blocked to limit or prevent upward deflection so that screw back out is inhibited.

Abstract: Ureteral catheters and assemblies are provided including: a drainage lumen including a proximal portion configured to be positioned in at least a portion of a patient's urethra and a distal portion configured to be positioned in a patient's ureter and/or kidney, the distal portion including a coiled retention portion including at least a first coil having a first diameter and a second coil having a second diameter, the first diameter being less than the second diameter; or wherein the retention portion extends radially outwardly from a portion of the distal end of the drainage lumen portion, the retention portion including a proximal end having a first diameter, a distal end having a second diameter, and a wall and/or surface extending therebetween, the retention portion having a second diameter is greater than the first diameter when deployed; or wherein the retention portion includes a plurality of drainage tubes.

Abstract: A polyaxial fastener is secured within an implant with a retaining ring. The ring is assembled onto a circumferential groove formed in the fastener head. The groove and ring are positionable, when the fastener is installed into an implant, at a wide portion of the mating polyaxial aperture in the implant. The ring is compressible into the groove to form a narrowed diameter, which is passable into a narrow diameter of the aperture, near an entrance to the aperture. The ring is released to expand and increase an overall diameter of the head and ring assembly, thereby rending the assembly too wide to pass by the narrow entrance to the aperture, thereby securing the assembly within the implant.

Abstract: A urine collection catheter is provided. The catheter includes: a conduit having an open distal end; a drainage tube positioned at least partially within the conduit; and a bladder superior wall support. The drainage tube includes one or more fluid ports or perforations for permitting fluid flow into a drainage lumen defined by the drainage tube. The bladder superior wall support includes a support cap and a plurality of support members extending from a proximal surface of the support cap through the open distal end of the conduit. The support cap is capable of being moved between a retracted position and a deployed position. In the deployed position, the distal end of the drainage tube is spaced apart from the support cap, such that the support cap supports portions of the superior wall of the bladder from occluding the one or more fluid ports or perforations of the drainage tube.

Abstract: Present application refers to a method, a model generation unit and a computer program (product) for generating trained models (M) of moving persons, based on physically measured person scan data (S). The approach is based on a common template (T) for the respective person and on the measured person scan data (S) in different shapes and different poses. Scan data are measured with a 3D laser scanner. A generic personal model is used for co-registering a set of person scan data (S) aligning the template (T) to the set of person scans (S) while simultaneously training the generic personal model to become a trained person model (M) by constraining the generic person model to be scan-specific, person-specific and pose-specific and providing the trained model (M), based on the co-registering of the measured object scan data (S).

Abstract: An orthopedic assembly may include an orthopedic device, an anchor, and a locking mechanism. The orthopedic device can be a plate member having an aperture that is configured to receive the anchor. The anchor can include a head, neck and shank portion. The head portion can include a plurality of arms separated by grooves that are capable of splaying. The assembly is configured such that when the locking mechanism is inserted into the head portion, this causes expansion of the arms of the head. This expansion locks and secures the anchor to the orthopedic device. Various instruments are provided that can deliver the locking mechanism to the anchor, and can provide impact to lock functionality.

Abstract: A transverse connector system having a first and a second locking element. The present invention also provides transverse rod having opposing first and second ends, the first end being retained within a portion of the first locking element and the second end being retained within a portion of the second locking element. The first locking element is configured with a connector body for engaging and capturing an elongated rod and a transverse rod simultaneously.

Abstract: Spine stabilization systems and methods for stabilizing the spine. In particular, the spinal stabilization system has an occipital plate configured with a central portion and at least two extension portions extending from the central portion. At least two rod receivers are positioned on each one of the at least two extension portions and the at least two rod receivers are adapted and configured to receive at least two elongated rods. At least two locking assemblies are adapted and configured to retain the at least two elongated rods within the at least two rod receivers. The occipital plate further includes a plurality of holes for receiving bone fasteners and includes a slot for receiving each one of the at least two rod receivers, and the rod receivers being capable of translating and rotating within the slots.

Abstract: An orthopedic assembly is described that comprises an orthopedic device, an anchor, and a locking mechanism. The orthopedic device can be a plate member having an aperture that is configured to receive the anchor. The anchor can include a head, neck and shank portion. The head portion can include a plurality of arms separated by grooves that are capable of splaying. The assembly is configured such that when the locking mechanism is inserted into the head portion, this causes expansion of the arms of the head. This expansion locks and secures the anchor to the orthopedic device. Various instruments are provided that can deliver the locking mechanism to the anchor, and can provide impact to lock functionality.

Abstract: Present application refers to a method, a model generation unit and a computer program (product) for generating trained models (M) of moving persons, based on physically measured person scan data (S). The approach is based on a common template (T) for the respective person and on the measured person scan data (S) in different shapes and different poses. Scan data are measured with a 3D laser scanner. A generic personal model is used for co-registering a set of person scan data (S) aligning the template (T) to the set of person scans (S) while simultaneously training the generic personal model to become a trained person model (M) by constraining the generic person model to be scan-specific, person-specific and pose-specific and providing the trained model (M), based on the co registering of the measured object scan data (S).

Abstract: The present invention is directed to a spine stabilization system and method for stabilizing the spine. In particular, the present invention is directed to a spinal stabilization system having an occipital plate configured with a central portion and at least two extension portions extending from the central portion. At least two rod receivers are positioned on each one of the at least two extension portions and the at least two rod receivers are adapted and configured to receive at least two elongated rods. At least two locking assemblies are adapted and configured to retain the at least two elongated rods within the at least two rod receivers. The occipital plate further includes a plurality of holes for receiving bone fasteners and includes a slot for receiving each one of the at least two rod receivers, and the rod receivers being capable of translating and rotating within the slots.

Abstract: This invention relates methods and compositions for identifying Colorectal Cancer (CRC) prognostic transcripts and groups of CRC prognostic transcripts useful in determining the prognosis of cancer in a patient, particularly for gastrointestinal cancer, such as gastric or colorectal cancer. Specifically, this invention relates to CRC cell culture-based methods to identify cell proliferation signatures.

Abstract: Embodiments of the disclosure provide a method and system for providing a diagnostic vascular window that may be used in real time to monitor a patient's fluid conditions in a variety of settings. The diagnostic vascular window may, for example, be used pre-surgery, during surgery, and post-surgery to determine whether a correct type and dose of diuretic drugs are being used for the patient. The diagnostic vascular window utilizes low flow accesses to view blood/fluids leaving and entering the patient's body. In addition, the same amount of fluids leaving the body enters the body, so there are no fluid losses or gains within the diagnostic vascular window. The low flow accesses in conjunction with a monitoring system allows for real-time measurements of blood parameters without fluid loss.

Abstract: The invention is an external apparatus for the addition of weight(s) to dumbbells and barbells. The external apparatus allows micro-incremental loading between 1.25 to 3.75 pounds on all types of dumbbells and barbells. The device is able to improve trainer and the trainee's ability to break plateaus and to maintain consistent weight progression. The use of this device promotes and stimulates the muscle growth of the user while training. The main advantage of the present invention that women get the significant benefit from this piece of equipment, however, men and women of all body types would benefit greatly from this device.