Abstract: Disclosed herein are several embodiments of a reduced pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters. Certain embodiments are directed to connectors used to connect fluid passage tube used in transmitting negative pressure to a fabric channel used in a suction adapter.

Abstract: Disclosed herein are several embodiments of a reduced pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters. Certain embodiments are directed to connectors used to connect fluid passage tube used in transmitting negative pressure to a fabric channel used in a suction adapter.

Abstract: The use of a tag moiety comprising a biotinylation domain, such as biotin carboxyl carrier protein (BCCP), as a protein folding marker and protein solubility enhancer in the orientated surface capture of products of heterologously expressed genes is described. Methods for increasing the solubility of proteins and determining the folded state of a protein are also disclosed. The uses and methods of the invention can be carried out in a multiplexed manner on more than one protein in the formation of libraries. In addition the nucleic acid molecule encoding the biotinylation domain of the tag moiety can be used to increase the proportion of clones in a library that express the protein of interest.

Abstract: A louvered shutter panel, such as for windows and doors, includes a pair of spaced-apart stiles, each stile having a longitudinally extending groove. The groove in each stile includes a first portion having a first cross-sectional shape and an adjacent second portion having a second cross-sectional shape. A pair of spaced-apart rails extends between the stiles, each of the rails having a tabbed portion received within the groove of the stile. The shutter panel also includes elongate inserts received within a portion of the groove of the stile. A plurality of louvers include pins that are rotationally received within spaced-apart holes in the inserts.

Abstract: A frame assembly for windows and doors includes a pair of side members and a pair of generally parallel cross members, each extending along a unique member axis. The cross members include a first frame portion and a second frame portion that extend generally along the member axis and are connected by a camming fastener that draws together and secures the first and second frame portions. A method of fabricating a shutter assembly includes forming a pair of C-shaped partial-frames, each from a side member coupled to portions of two cross-members. The method includes co-axially aligning corresponding portions of the two cross-members along two axes and joining the two C-shaped partial-frames with camming fasteners.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: An aptamer-based SERS detection technique that directly monitors an aptamer-analyte capture event by generating spectroscopic information regarding the identity of the analyte that has been bound to the aptamer from a complex biological sample. A reproducible SERS spectrum is measured for an aptamer-analyte complex formed on a metal surface and this spectral information is used directly to identify the specific aptamer-analyte complex and optionally also to quantify the analyte in the sample, thus enabling discrimination between true and false positives in quantitative analyte assays on complex biological samples. In one embodiment the aptamer is attached directly to the metal surface and surrounded by a self-assembled monolayer (SAM) of amphiphilic molecules. In an alternative embodiment the metal surface is coated with a SAM and the aptamer is attached to the amphiphilic molecules of the SAM.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: Disclosed herein are several embodiments of a reduced pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters. Certain embodiments are directed to connectors used to connect fluid passage tube used in transmitting negative pressure to a fabric channel used in a suction adapter.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: A method of identifying and imaging a high risk collision object relative to a host vehicle includes arranging a plurality of N sensors for imaging a three-hundred and sixty degree horizontal field of view (hFOV) around the host vehicle. The sensors are mounted to a vehicle in a circular arrangement so that the sensors are radially equiangular from each other. For each sensor, contrast differences in the hFOV are used to identify a unique source of motion (hot spot) that is indicative of a remote object in the sensor hFOV. A first hot spot in one sensor hFOV is correlated to a second hot spot in another hFOV of at least one other N sensor to yield range, azimuth and trajectory data for said object. The processor then assesses a collision risk with the object according to the object's trajectory data relative to the host vehicle.

Abstract: Protein arrays that allow the analysis of differentially expressed proteins in parallel are disclosed. Methods for making such arrays, and their use for screening and/or evaluating the effect of chemical entities, including drug and therapeutic moieties, are described. The arrays can also be used to screen for compounds, peptides, or proteins, which modulate the interaction between a protein and the differentially expressed protein.

Abstract: A system and method for the capture, storage and manipulation of remote information is disclosed. The system includes at least one remote information capture device located at a remote site for capturing remote data, a central database accessible by the remote capture device for storing the captured remote data, and a computer program operative to manipulate the captured data. The method includes the steps of capturing remote data, storing the captured remote data, and manipulating the stored data.

Abstract: The present invention describes methods for the preparation of protein arrays of full length proteins. The use of such arrays in screening methods is also described.

Abstract: We disclose a method of treating priapism in a mammal by administering to the mammal a composition containing an effective amount of an inhibitor of adenosine signaling and a pharmaceutically-acceptable carrier, wherein the inhibitor of adenosine signaling has at least one activity selected from the group consisting of decreasing adenosine levels in the mammal, inhibiting adenosine receptor activity in the mammal, and inhibiting signaling pathways downstream of an adenosine receptor in the mammal.

Abstract: The invention relates to crystals of the influenza virus neuraminidase protein, their structures and their use.

Abstract: Fluid ejection head assemblies, fluid ejection devices, and methods for improving fluid sealing of fluid ejection head assemblies. One such fluid ejection head assembly includes a substrate cavity and a substantially planar surface surrounding the substrate cavity. The substantially planar surface contains at least one external vent, at least one internal vent channel, and a plurality of vents in fluid flow communication with the substrate cavity and providing fluid flow communication between the internal vent channel and the external vent. The plurality of vents, the at least one external vent and the at least one internal vent channel are disposed in fluid flow communication with an environment external to the substrate cavity for flow of a gas associated with an adhesive at least partially disposed in the substrate cavity, to the environment during the curing of the adhesive.

Abstract: The inventors herein describe methods for the production of a functional human, animal, plant or microbe protein arrays and methods to assay for interactions between the proteins on the array with molecules of interest, for example, using such arrays to determine the in vitro metabolite profile of any drug. Such protein arrays can be used, for example, to assay, in a parallel fashion, the protein products of DNA sequences encoding drug metabolizing enzymes (DMES) to obtain a toxicology profile. Also described herein is a novel DME expression and purification strategy using detergents and not requiring an ultra-centrifugation step.

Abstract: A system and method for the capture, storage and manipulation of remote information is disclosed. The system includes at least one remote information capture device located at a remote site for capturing remote data, a central database accessible by the remote capture device for storing the captured remote data, and a computer program operative to manipulate the captured data. The method includes the steps of capturing remote data, storing the captured remote data, and manipulating the stored data.

Abstract: A liquid dispensing instrument, such as a marker assembly, the instrument having a barrel, a release mechanism, and a cap. The release mechanism can comprise a deformable arm affixed to the barrel or the cap, for pushing the cap and barrel apart. In one embodiment, a liquid dispensing instrument comprises a barrel having a first end and a second end, and a cap disposed over the first end of the barrel. The barrel has a deformable arm having a fixed end affixed to the barrel and a free end, the deformable arm protruding radially away from the barrel. The free end of the deformable arm pushes the cap away from the first end of the barrel when the deformable arm is pushed radially toward the barrel.