Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A gasket includes a plurality of compression limiters each including a plastic body having a fastener aperture extending there through and a plurality of flow holes extending there through. An elastomeric body defines a perimeter sealing body molded around the plurality of compression limiters at spaced locations around the perimeter sealing body. The elastomeric body extends through the plurality of flow holes in the plurality of compression limiters.

Abstract: A drug reconstitution system includes a robotic arm movable between a plurality of positions, at least one bracket member operably coupled with the robotic arm, and at least one coaxial needle operably coupled with the robotic arm. The at least one bracket member includes a mounting region, a support surface, an upper surface, and a throughbore extending through the support surface and the upper surface. The at least one coaxial needle is movably disposed between the throughbore of the at least one bracket member. The at least one coaxial needle is adapted to pierce at least a portion of a vial and dispense a liquid into the vial during drug reconstitution.

Abstract: An over-varnish unit and mandrel pre-spin system for a can decorator, especially for beverage can bodies, can have a mandrel pre-spin belt that is outside of the over-varnish unit housing. The position of the can infeed on the mandrel wheel and the print point is controlled.

Abstract: Methods, devices and systems are disclosed for improved depth perception in stereoscopic night vision devices. Among these are embodiments for aligning information overlays in the stereo view with associated objects, and for generating stereo information from single lenses or intensifiers. In some illustrative embodiments, a camera and position sensor are provided for at least two viewers, e.g., a pilot and a copilot, such that when a scene overlaps between viewers, the system produces a stereoptic scene, in which the users can more accurately determine a difference in depth between two or more distant objects. An illustrative binocular night vision system uses a high-resolution depth map to present binocular images to a user. In some embodiments, supplementary content can be overlaid, with an appropriate binocular disparity that is based on the depth map.

Abstract: A device for storage, generation, transmission, distribution and/or other use of electrical energy, comprising a flame retardant molded article, comprising a polymer matrix containing a crosslinked aliphatic polyketone (PK) in combination with at least one flame retardant and to a method for improving the flame retardant properties of molded articles for electrical devices. In addition electric vehicles, battery energy storage systems, power tools and devices for power generation and to parts therof, comprising a flame retardant molded article, comprising a polymer matrix containing a crosslinked aliphatic polyketone (PK) in combination with at least one flame retardant.

Abstract: Castout handling in a distributed cache topology, including: detecting, by a first cache of a plurality of caches, a cache miss; providing, by the first cache to each other cache of the plurality of caches, a message comprising: data indicating a cache address corresponding to the cache miss; and data indicating a cache line to be evicted.

Abstract: A computer system includes a processor core and a memory system in signal communication with the processor core. The memory system includes a first cache and a second cache. The first cache is arranged at a first level of a hierarchy in the memory system and is configured to store a plurality of first-cache entries. The second cache is arranged at a second level of the hierarchy that is lower than the first level, and stores a plurality of second-cache entries. The first cache maintains a directory that contains information for each of the first-cache entries. The second cache maintains a shadow pointer directory (SPD) that includes one or more SPD entries that maps each of the first-cache entries to a corresponding second cache entry at a lower-level cache location.

Abstract: Thermally conductive electrically insulating compositions and structures and devices comprising such materials. In various embodiments, such materials comprise liquid crystal polymer and fillers, wherein the fillers comprise boron nitride and glass fiber. In various embodiments, the liquid crystal polymer is selected from the group consisting of semi-aromatic copolyesters, copolyamides, polyester-co-amides, and mixtures thereof.

Abstract: Fire protection materials comprising an endothermic hydrate, an intumescent, a heat resistant fiber and an elastomeric polymer. In various embodiments, endothermic hydrate comprises aluminum trihydrate, the intumescent comprises expandable graphite, and the heat resistant fiber comprises poly(p-phenylene terephthalamide). The elastomeric polymer may be a polyorganosiloxane, such as a phenyl substituted polydimethyl siloxane. Also described are structures comprising such fire protection materials, e.g., separators and other battery containment structures such as for use with high density lithium batteries.

Abstract: A gasket includes a plurality of compression limiters each including a plastic body having a fastener aperture extending there through and a plurality of flow holes extending there through. An elastomeric body defines a perimeter sealing body molded around the plurality of compression limiters at spaced locations around the perimeter sealing body. The elastomeric body extends through the plurality of flow holes in the plurality of compression limiters.

Abstract: Thermally conductive electrically insulating compositions and structures and devices comprising such materials. In various embodiments, such materials comprise liquid crystal polymer and fillers, wherein the fillers comprise boron nitride and glass fiber. In various embodiments, the liquid crystal polymer is selected from the group consisting of semi-aromatic copolyesters, copolyamides, polyester-co-amides, and mixtures thereof.

Abstract: A compressor may include a housing, a piston, a valve plate, a discharge valve and a head cover. The housing defines a cylinder. The piston is disposed within the housing and is movable within the cylinder. The valve plate is mounted to the housing and may include a discharge passage extending through the valve plate and defined by a discharge valve seat. The discharge valve is movable between a first position in which the discharge valve is seated on the discharge valve seat to restrict fluid flow through the discharge passage and a second position in which the discharge valve is spaced apart from the discharge valve seat to allow fluid flow through the discharge passage. The head cover may include a guide post including a pocket that receives a valve stem of the discharge valve.

Abstract: Embodiments are provided for implementing efficient resource allocation maintaining fairness between operation types. Embodiments include receiving an operation, and determining a number of resources that are required for the received operation. Embodiments also include determining a number of available resources, comparing the number of required resources and the number of available resources, and allocating the available resources in a first mode or a second mode based at least in part on the comparison and a number of queued operations.

Abstract: Embodiments includes a computer-implemented method, a system and computer-program product for modifying central serialization of requests in multiprocessor systems. Some embodiments includes receiving an operation requiring resources from a pool of resources, determining an availability of the pool of resources required by the operation, and selecting a queue of a plurality of queues to queue the operation based at least in part on the availability of the pool of resources. Some embodiments also include setting a resource needs register and needs register for the selected queue, and setting a take-two bit for the selected queue.

Abstract: Embodiments of the present invention are directed to a computer-implemented method for cache eviction. The method includes detecting a first data in a shared cache and a first cache in response to a request by a first processor. The first data is determined to have a mid-level cache eviction priority. A request is detected from a second processor for a same first data as requested by the first processor. However, in this instance, the second processor has indicated that the same first data has a low-level cache eviction priority. The first data is duplicated and loaded to a second cache, however, the data has a low-level cache eviction priority at the second cache.

Abstract: Processing simultaneous data requests regardless of active request in the same addressable index of a cache. In response to the cache miss in the given congruence, if the number of other compartments in the given congruence class that have an active operation is less than a predetermined threshold, setting a Do Not Cast Out (DNCO) pending indication for each of the compartments that have an active operation in order to block access to each of the other compartments that have active operations and, if the number of other compartments in the given congruence class that have an active operation is not less than a predetermined threshold, blocking another cache miss from occurring in the compartments of the given congruence class by setting a congruence class block pending indication for the given congruence class in order to block access to each of the other compartments of the given congruence class.

Abstract: Processing simultaneous data requests regardless of active request in the same addressable index of a cache. In response to the cache miss in the given congruence, if the number of other compartments in the given congruence class that have an active operation is less than a predetermined threshold, setting a Do Not Cast Out (DNCO) pending indication for each of the compartments that have an active operation in order to block access to each of the other compartments that have active operations and, if the number of other compartments in the given congruence class that have an active operation is not less than a predetermined threshold, blocking another cache miss from occurring in the compartments of the given congruence class by setting a congruence class block pending indication for the given congruence class in order to block access to each of the other compartments of the given congruence class.

Abstract: Embodiments of the present invention are directed to a computer-implemented method for cache eviction. The method includes detecting a first data in a shared cache and a first cache in response to a request by a first processor. The first data is determined to have a mid-level cache eviction priority. A request is detected from a second processor for a same first data as requested by the first processor. However, in this instance, the second processor has indicated that the same first data has a low-level cache eviction priority. The first data is duplicated and loaded to a second cache, however, the data has a low-level cache eviction priority at the second cache.

Abstract: Embodiments includes a computer-implemented method, a system and computer-program product for modifying central serialization of requests in multiprocessor systems. Some embodiments includes receiving an operation requiring resources from a pool of resources, determining an availability of the pool of resources required by the operation, and selecting a queue of a plurality of queues to queue the operation based at least in part on the availability of the pool of resources. Some embodiments also include setting a resource needs register and needs register for the selected queue, and setting a take-two bit for the selected queue.