Abstract: Spirocyclic 2,3-dihydro-7-azaindole compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the spirocyclic 2,3-dihydro-7-azaindole compounds.

Abstract: A method of aggregating and disseminating time sensitive information. A data source is searched to identify recently-posted information items matching predetermined selection criteria. A respective relevance score is calculated for each identified information item. A respective urgency rating is determined for each identified information item. Each information item is triaged using the urgency rating, and disseminated to at least one client based on the triage result.

Abstract: When a storage block is returned to the store allocator the master capability table (MCT) entry defining the block must also be deallocated. However, an arbitrary number of capability pointers to that block may still exist in the live system and these must be cancelled before the MCT entry is re-used. The cancellation operation ideally requires a system freeze which cannot be contemplated in a real-time environment. Accordingly each MCT entry includes a "garbage" bit and "visited" bit and the garbage bit is set each time a "load capability register" instruction is performed and a garbage collection process is used to detect blocks which can be freed.