Patents by Inventor Michael Block Lazarus

Michael Block Lazarus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CULLIN-RING E3 UBIQUITIN LIGASE 4 INHIBITOR COMPOUNDS AND METHODS OF THEIR USE
    Publication number: 20240174649
    Abstract: Disclosed herein are compounds that inhibit cullin-RING E3 ubiquitin ligase 4, a method of inhibiting the catalytic activity of a Cullin-RING E3 Ubiquitin (Ub) Ligase (CRL) in a cell, compositions comprising the inhibitor compounds, a method of treating a tumor, and a method of treating a subject for cancer.
    Type: Application
    Filed: February 1, 2022
    Publication date: May 30, 2024
    Inventors: Robert J. DEVITA, Zhen-Qiang PAN, Khoi Q. HUYNH, Moses MOUSTAKIM, Kenneth WU, Chalada SUEBSUWONG, Benjamin D. HOPKINS, Peng-Jen CHEN, Michael Block LAZARUS
  • Diphosphate mimetics and uses thereof
    Patent number: 9573911
    Abstract: The present invention provides compounds of Formulae (I)-(V), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. In one aspect, compounds of the present invention are useful as glycosyltransferase inhibitors, in particular, O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) inhibitors. In another aspect, compounds of the present invention are useful as kinase inhibitors, in particular, PLK1 inhibitors, GSK3P inhibitors, or MAPKAPK2 inhibitors. The present invention further provides methods of using the inventive compounds, e.g., as biological probes to study the inhibition of OGT and/or kinase activity and as therapeutics, e.g., for the treatment of OGT-associated and/or kinase-associated conditions.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: February 21, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Suzanne Walker Kahne, Jiaoyang Jiang, Michael Block Lazarus
  • -GlcNAc transferase inhibitors and uses thereof
    Patent number: 8957075
    Abstract: The present invention provides inhibitors of O-GIcNAc transferase. Typically, the inhibitors are quinolinone-6-sulfonamides. The invention also provides pharmaceutical compositions thereof and methods for using the same in diabetes and complications thereof, neurodegenerative diseases, cancers, autoimmune diseases, and inflammatory diseases.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: February 17, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Suzanne Walker Kahne, Michael Block Lazarus, Benjamin J. Gross
  • DIPHOSPHATE MIMETICS AND USES THEREOF
    Publication number: 20140163079
    Abstract: The present invention provides compounds of Formulae (I)-(V), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. In one aspect, compounds of the present invention are useful as glycosyltransferase inhibitors, in particular, O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) inhibitors. In another aspect, compounds of the present invention are useful as kinase inhibitors, in particular, PLK1 inhibitors, GSK3P inhibitors, or MAPKAPK2 inhibitors. The present invention further provides methods of using the inventive compounds, e.g., as biological probes to study the inhibition of OGT and/or kinase activity and as therapeutics, e.g., for the treatment of OGT-associated and/or kinase-associated conditions.
    Type: Application
    Filed: July 6, 2012
    Publication date: June 12, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Suzanne Walker Kahne, Jiaoyang Jiang, Michael Block Lazarus
  • O-GLCNAC TRANSFERASE INHIBITORS AND USES THEREOF
    Publication number: 20120108605
    Abstract: The present invention provides inhibitors of O-GIcNAc transferase. Typically, the inhibitors are quinolinone-6-sulfonamides. The invention also provides pharmaceutical compositions thereof and methods for using the same in diabetes and complications thereof, neurodegenerative diseases, cancers, autoimmune diseases, and inflammatory diseases.
    Type: Application
    Filed: June 1, 2010
    Publication date: May 3, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: Suzanne Walker Kahne, Michael Block Lazarus, Benjamin J. Gross