Patents by Inventor Michael Boddy

Michael Boddy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070213256
    Abstract: The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, proteins encoded thereby, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, and methods for treating a cell using such nucleic acids or proteins.
    Type: Application
    Filed: May 8, 2007
    Publication date: September 13, 2007
    Inventors: Paul Russell, Jorge Vialard, Michael Boddy, Paul Shanahan, Antonia Lopez-Girona, Cecile-Marie Denis, Clare McGowan
  • Publication number: 20070072794
    Abstract: The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, pharmaceutical compositions and the formulation of such compositions comprising said nucleic acids or proteins expressed therefrom, methods for treating a cell using such nucleic acids, proteins or pharmaceutical compositions, and the use of such nucleic acids or proteins in formulating a pharmaceutical preparation.
    Type: Application
    Filed: August 27, 2002
    Publication date: March 29, 2007
    Inventors: Paul Russell, Jorge Vialard, Michael Boddy, Paul Shanahan, Antonia Lopez-Girona, Cecile-Marie Denis, Clare McGowan
  • Publication number: 20060003434
    Abstract: Isolated mammalian Mus81-Eme endonuclease complexes comprise an Mus81 protein portion and an Eme protein portion. A method of identifying a chemical compound that modulates mammalian cellular response to DNA damage comprises contacting a chemical compound to be tested with a biochemical mixture containing an isolated mammalian Mus81-Eme1 endonuclease complex, a source of magnesium ion, and a suitable DNA substrate; measuring the activity level of mammalian Mus81-Eme endonuclease complex in the mixture; comparing the measured activity level to the activity level of a substantially similar mixture of isolated Mus81-Eme1 endonuclease, magnesium ion, and DNA substrate in the absence of the chemical compound to be tested; and selecting a chemical compound that increases or decreases the endonuclease activity. Isolated mammalian Eme1 and Eme2 proteins derived from humans and murine species and isolated nucleic acids encoding the proteins are also described.
    Type: Application
    Filed: June 30, 2004
    Publication date: January 5, 2006
    Inventors: Michael Boddy, Veronique Blais, Xiao-Bo Chen, Clare McGowan, Pierre-Henri Gaillard, Paul Russell