Abstract: The ability to improve the adjusting of technical parameters in therapy plans found by Pareto navigation constitutes a technical problem, along with facilitating the decision-making of the planner (also called user) and simplifying the mathematical calculation of the solution. Proposed is a way to find and establish a therapy plan among a plurality of plan proposals for cancer therapy, each plan proposal representing as a solution one point in a navigation space (N) containing a plurality of setting parameters and establishing in a machine space (M) a setting for radiation doses to be administered by a radiation therapy machine for cancer therapy. The navigation space (N) contains at least one Pareto front (200) behind or on which available treatment plans are located as possible solutions and among which a user navigates, whereby a first plurality of available solutions calculated in advance as plan proposals is provided in a memory and retrieved or read out from the memory for display.

Abstract: A medical system for applying negative pressure within a gastrointestinal tract of a subject. The system includes a linearizing element, an elongate tube, and a fluid-tight lumen. The elongate tube includes a longitudinal channel, portals in fluid communication with the channel, and a longitudinal shape-forming wire. The elongate tube has a delivery state when associated with the linearizing element and a coiled state when dissociated therefrom. When the elongate tube is in the coil form, a proximal end of the coil forms a shoulder. At a region of the shoulder, the shape-forming wire is modified. The elongate tube has a first flexure modulus in a coil-radial direction and a second flexure modulus, greater than the first flexure modulus, in a coil-axial direction. The fluid-tight lumen is in fluid communication with the elongate tube and couples to a source of negative pressure.

Abstract: A medical system for applying negative pressure within a gastrointestinal tract of a subject, including a linearizing element, an elongate tube, and a fluid-tight lumen. The elongate tube includes a channel along a longitudinal portion, at least one portal in fluid communication with the channel, and a shape-forming wire extending along a longitudinal length of the elongate tube. The elongate tube has a delivery state when associated with the linearizing element and a first operative state when dissociated from the linearizing element, in which the elongate tube forms a coil. A rotational orientation of the shape-forming wire relative to the elongate tube is fixed throughout an entire length of the shape-forming wire. The fluid-tight lumen is in fluid communication with the elongate tube, and is adapted to couple to a source of negative pressure and to deliver negative pressure to the elongate tube.

Abstract: A wireless-enabled dissolution instrument calibration system including a vessel module measuring a first set of data related to the calibration of dissolution instrument, an instrument module measuring a second set of data related to the calibration of the dissolution instrument, a data conversion module configured to receive the first and second set of data and convert the data into visual data on a report, and a wireless transceiver coupled to the vessel module, the instrument module, and the data conversion module. The wireless transceiver transmits the first and second set of data to the data conversion module automatically as the first and second set of data is measured. The data conversion module organizes the visual data on the report into spreadsheets and/or tables by the particular measurement and renders the visual data un-editable to safeguard compliance.

Abstract: The subject of this disclosure is a method of multi-criteria optimization (MCO): in particular, the designing or fashioning of a therapy as a treatment plan for a person (P) with a treatable disease who is being treated with non-simultaneous fractionated doses of the at least two radiation devices (100, 200), wherein the designed or fashioned treatment plan defines a plurality of technical settings that are adjusted on the radiation devices prior to the treatment.

Abstract: Multi-criteria optimization of a process, such as a chemical or engineering process, is to be enabled or improved. Interaction between a user and an optimization tool is to be improved as well. A procedure for designing or devising a process is proposed to achieve this. The procedure has the steps of providing a value of a first design variable (x1, x2, . . . , xD) of the process; providing a value of a first parameter (y1, y2, . . . , yK) and a value of a second parameter (y1, y2, . . . ,yK), whereby the values of the parameters (y1, y2, . . . , yK) are formed based on the value of the first design variable (x1, x2, . . . , xD); providing a Pareto frontier (10) for the two parameters (y1, y2, . . . , yK); and determining a deviation of the value of the first parameter (y1, y2, . . . , yK) to a point (11, 12, . . . , 16) of the Pareto frontier (10) and/or determining a deviation of the value of the second parameter (y1, y2, . . . , yK) to the point (11, 12, . . . , 16) of the Pareto frontier (10).

Abstract: The aim of the invention is to allow patients to be individually provided with good therapy, whereby the quality of the therapy also includes minimizing the waiting time of each patient (under “time to treatment”). Proposed is a method for designing or fashioning a therapy as a treatment plan, before treatment, and with interactive navigation on a display device (10). Multiple technologies (A, B, . . . Z) of radiation devices (100, 200, 300) are available for selection, including at least one technology (A) with a radiation device (100) for emitting protons and at least one technology (B) with a radiation device (200) for emitting photons. After designing or fashioning, for a person (P) who is to be treated with therapy that can be provided by the radiation device (100, 200, 300), the designed or fashioned plan defines a plurality of technical settings that are adjusted on the radiation device(s) of the selected technology/technologies. For at least some of the technologies (A, B, . . .

Abstract: The aim of the invention is to provide a procedure which enables or improves multi-criteria optimization of a chemical or procedural process. Interaction between a user and an optimization tool is to be improved as well. This is achieved by interactive navigation on a display device (10). At least a first and a second configuration (A, B, . . . Z) are available for selection, and at least a first Pareto frontier (101, . . . ) is formed for the first configuration (A) and at least a second Pareto frontier (201, . . . ) for the second configuration (B). Based on the first Pareto frontier (101, . . . ) for the first configuration (A) and the second Pareto frontier (201, . . . ) for the second configuration (B), a resulting Pareto frontier (801) is or will be formed.

Abstract: A medical system for applying negative pressure within a gastrointestinal tract of a subject. The medical system includes an elongate tube defining at least one interior channel, a plurality of orifices in fluid communication with the interior channel, and at least one exterior channel. The exterior channel is in fluid communication with the interior channel via at least one of the orifices. The elongate tube has a delivery state, and a first operative state in which the elongate tube forms a coil including a plurality of loops. A fluid-tight lumen is in fluid communication with the elongate tube. The lumen is adapted to couple to a source of negative pressure for delivery of negative pressure to the elongate tube. In the first operative state of the elongate tube, a length of the coil is at least 15 mm and the plurality of loops includes at least 4 loops.

Abstract: The present invention generally relates to a system optimization procedure. The method includes a) providing, via an input channel, a system model for modelling the chemical mixture, which associates a set of design parameters with a plurality of objective parameters that represent design characteristics of the chemical mixture, wherein the set of design parameters comprises a chemical mixture recipe having two or more ingredients, and the plurality of objective parameters comprises two or more physicochemical properties of the chemical mixture; b) defining, via the input channel, a set of primary optimization objective parameters, c) performing, by a processor, a multi-objective optimizing process on the system model by exploring a plurality of design configurations by assigning specified values to the set of design parameters; and d) determining, by the processor, if the multi-objective optimizing process yields a degenerated multi-objective optimal design.

Abstract: The present invention relates generally to the field of chemical formulations in a chemical production facility, and more particularly to providing assistance for producing a chemical formulation in a chemical production facility.

Abstract: The present invention includes a method for representing a plurality of pre-calculated solutions in radiation therapy that are stored in a database and displayed in a manner controllable by a user. Arrays of DVH curves provide the user with essential information on the ‘quality of a plan’. A DVH diagram is displayed as a main diagram, wherein only one of the solutions is visually represented at a time. By selecting a first starting point on a selected DVH curve as the main diagram, a first straight axis extending through the first starting point is placed. A first region, located around the first starting point and on the first straight axis, is highlighted as a first control region for controllable visualization of the plurality of currently non-displayed solutions stored in the database, the DVH curves of which correspond to the selected DVH curve and intersect the first straight axis.

Abstract: The aim of the invention is to provide a planner with the opportunity to effect local improvement of an IMRT treatment plan which is available to him. To this end, a method for customizing a dose distribution setting for a technical appliance in tumor therapy is proposed.

Abstract: The present invention includes a method for representing a plurality of pre-calculated solutions in radiation therapy that are stored in a database and displayed in a manner controllable by a user. Arrays of DVH curves provide the user with essential information on the ‘quality of a plan’. A DVH diagram is displayed as a main diagram, wherein only one of the solutions is visually represented at a time. By selecting a first starting point on a selected DVH curve as the main diagram, a first straight axis extending through the first starting point is placed. A first region, located around the first starting point and on the first straight axis, is highlighted as a first control region for controllable visualization of the plurality of currently non-displayed solutions stored in the database, the DVH curves of which correspond to the selected DVH curve and intersect the first straight axis.

Abstract: The present invention includes a method for representing a plurality of pre-calculated solutions in radiation therapy that are stored in a database and displayed in a manner controllable by a user. Arrays of DVH curves provide the user with essential information on the ‘quality of a plan’. A DVH diagram is displayed as a main diagram, wherein only one of the solutions is visually represented at a time. By selecting a first starting point on a selected DVH curve as the main diagram, a first straight axis extending through the first starting point is placed. A first region, located around the first starting point and on the first straight axis, is highlighted as a first control region for controllable visualization of the plurality of currently non-displayed solutions stored in the database, the DVH curves of which correspond to the selected DVH curve and intersect the first straight axis.

Abstract: The aim of the invention is to provide a planner with the opportunity to effect local improvement of an IMRT treatment plan which is available to him. To this end, a method for customizing a dose distribution setting for a technical appliance in tumor therapy is proposed.

Abstract: The present invention includes a method for representing a plurality of pre-calculated solutions in radiation therapy that are stored in a database and displayed in a manner controllable by a user. Arrays of DVH curves provide the user with essential information on the ‘quality of a plan’. A DVH diagram is displayed as a main diagram, wherein only one of the solutions is visually represented at a time. By selecting a first starting point on a selected DVH curve as the main diagram, a first straight axis extending through the first starting point is placed. A first region, located around the first starting point and on the first straight axis, is highlighted as a first control region for controllable visualization of the plurality of currently non-displayed solutions stored in the database, the DVH curves of which correspond to the selected DVH curve and intersect the first straight axis.

Abstract: The present invention includes a method for representing a plurality of pre-calculated solutions in radiation therapy that are stored in a database and displayed in a manner controllable by a user. Arrays of DVH curves provide the user with essential information on the ‘quality of a plan’. A DVH diagram is displayed as a main diagram, wherein only one of the solutions is visually represented at a time. By selecting a first starting point on a selected DVH curve as the main diagram, a first straight axis extending through the first starting point is placed. A first region, located around the first starting point and on the first straight axis, is highlighted as a first control region for controllable visualization of the plurality of currently non-displayed solutions stored in the database, the DVH curves of which correspond to the selected DVH curve and intersect the first straight axis.

Abstract: The present invention includes a method for representing a plurality of pre-calculated solutions in radiation therapy that are stored in a database and displayed in a manner controllable by a user. Arrays of DVH curves provide the user with essential information on the ‘quality of a plan’. A DVH diagram is displayed as a main diagram, wherein only one of the solutions is visually represented at a time. By selecting a first starting point on a selected DVH curve as the main diagram, a first straight axis extending through the first starting point is placed. A first region, located around the first starting point and on the first straight axis, is highlighted as a first control region for controllable visualization of the plurality of currently non-displayed solutions stored in the database, the DVH curves of which correspond to the selected DVH curve and intersect the first straight axis.

Abstract: The aim of the invention is to provide a planner with the opportunity to effect local improvement of an IMRT treatment plan which is available to him. To this end, a method for customizing a dose distribution setting for a technical appliance in tumor therapy is proposed. A first plan (10) is read from a data memory (100). The first plan (10) for dose distribution in a plan volume (Z) is presented on a presentation device (110), the reason for this being the possibility of setting the technical appliance for tumor therapy to dispense the set dose distribution to a patient. The presentation is made for the purpose of changing the first plan (10) in at least one degree of fineness (10a) specific in terms of volume and for producing or ascertaining a causal follow-up plan for the setting on the technical appliance for tumor therapy.