Patents by Inventor Michael Bottger

Michael Bottger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PDGFRBETA-FC FUSION PROTEINS AND USES THEREOF
    Publication number: 20160009776
    Abstract: The present disclosure provides PDGFRbeta-Fc fusion proteins, or biologically active fragments thereof, comprising an extracellular domain of PDGFRbeta, or a biologically active fragment thereof, a linker and a Fc domain, wherein said fusion protein binds one or more of platelet-derived growth factor ligands with high affinity. The PDGFRbeta-Fc fusion proteins, or biologically active fragments thereof, accordingly, can be used to treat pathological neovascularization and fibrosis, e.g. cancer, ocular neovascular disorders or nephropathies. The disclosure also provides methods for treating ocular neovascular disorders with these fusion proteins without increasing vascular leakage. Such PDGFRbeta-Fc fusion proteins, or biologically active fragments thereof, exhibit increased terminal half time in the eye.
    Type: Application
    Filed: July 10, 2014
    Publication date: January 14, 2016
    Inventors: Lars Linden, Thomas Schlange, Andreas Wilmen, Mark Trautwein, Tibor Schomber, Michael Bottger, Jürgen Klar, Simone Greven
  • TOPICAL OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION CONTAINING REGORAFENIB
    Publication number: 20150328145
    Abstract: The present invention relates to topical ophthalmological pharmaceutical compositions containing regorafenib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof but without hydrophobic silica and its process of preparation and its use for treating ophthalmological disorders.
    Type: Application
    Filed: December 21, 2013
    Publication date: November 19, 2015
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Michael BOTTGER, Georges VON DEGENFELD, Julia FREUNDLIEB, Claudia HIRTH-DIETRICH, Joerg KELDENICH, Jurgen KLAR, Uwe MUENSTER, Andreas OHM, Annett RICHTER, Bernd RIEDL
  • TOPICAL OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION CONTAINING SUNITINIB
    Publication number: 20150174096
    Abstract: The present invention relates to topical ophthalmological pharmaceutical compositions containing sunitinib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating ophthalmological disorders.
    Type: Application
    Filed: June 10, 2013
    Publication date: June 25, 2015
    Applicant: Bayer Healthcare LLC
    Inventors: Michael Bottger, Georges Von Degenfeld, Julia Freundlieb, Claudia Hirth-Dietrich, Joerg Keldenich, Jurgen Klar, Uwe Muenster, Andreas Ohm, Annett Richter, Bernd Riedl, Joachim Telser
  • TOPICAL OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION CONTAINING CEDIRANIB
    Publication number: 20150165028
    Abstract: The present invention relates to topical ophthalmological pharmaceutical compositions containing cediranib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating ophthalmological disorders.
    Type: Application
    Filed: June 10, 2013
    Publication date: June 18, 2015
    Applicant: Bayer Healthcare LLC
    Inventors: Michael Bottger, Georges Von Degenfeld, Julia Freundlieb, Claudia Hirth-Dietrich, Joerg Keldenich, Jurgen Klar, Uwe Muenster, Andreas Ohm, Annett Richter, Bernd Riedl, Joachim Telser
  • TOPICAL OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION CONTAINING REGORAGENIB
    Publication number: 20140296301
    Abstract: The present invention relates to topical ophthalmological pharmaceutical compositions containing regorafenib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating ophthalmological disorders.
    Type: Application
    Filed: June 26, 2012
    Publication date: October 2, 2014
    Applicants: BAYER PHARMA AKTIENGESELLSCHAFT, BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Michael Bottger, Georges Von Degenfeld, Julia Freundlieb, Claudia Hirth-Dietrich, Joerg Keldenich, Jurgen Klar, Uwe Muenster, Andreas Ohm, Annett Richter, Bernd Riedl
  • TOPICAL OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION CONTAINING REGORAFENIB
    Publication number: 20140179745
    Abstract: The present invention relates to topical ophthalmological pharmaceutical compositions containing regorafenib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof but without hydrophobic silica and its process of preparation and its use for treating ophthalmological disorders.
    Type: Application
    Filed: December 16, 2013
    Publication date: June 26, 2014
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Michael BOTTGER, Georges VON DEGENFELD, Julia FREUNDLIEB, Claudia HIRTH-DIETRICH, Joerg KELDENICH, Jurgen KLAR, Uwe MUENSTER, Andreas OHM, Annett RICHTER, Bernd RIEDL
  • Method for improving transfection efficiency
    Publication number: 20030175975
    Abstract: The invention relates to a method for improving transfection efficiency by using K16 peptides. The invention further relates to novel K16 peptides, especially to the K16-CYCi, having the peptide sequence: K1 CYC (1). and to K16mVprN having the peptde sequence KKKKKKKKKKKKKKKGGGC NEWTLELLEELKNEAVRHE.
    Type: Application
    Filed: March 10, 2003
    Publication date: September 18, 2003
    Inventors: Regis Cartier, Michael Bottger, Annekathrin Haberland, Regins Reszka