Abstract: A device for collecting a biological sample in a patient, the device includes an expandable member sized for placement within the patient, the expandable member designed to transition between a plurality of states including a collapsed state and a sampling state; a handle in fluid communication with the expandable member; and an indicator configured to identify a status of the expandable member in response to the expandable member transitioning from one state to another.

Abstract: A self-anchoring catheter is provided that includes a body, an anchor portion, and an actuator. The body having a proximal end and a distal end, and defining a pathway therebetween, the body being axially rigid. The anchor portion can be imparted on the body to secure the body to surrounding tissue. The actuator can be disposed adjacent the proximal end of the body to positionally control movement of the anchor portion and its position relative to the actuator.

Abstract: An intraosseous port device includes a body having a proximal portion configured and arranged for subcutaneous placement and having a first channel, and a distal portion designed for intraosseous placement at a site of interest and having a second channel in fluid communication with the first channel to define a pathway from the proximal portion to the site of interest, a penetrable seal occluding at least a portion of the first channel, and a retention ring coupled to at least one of the body and the penetrable seal.

Abstract: Systems and methods for treatment of tissue including an expandable member designed to be positioned at a site of interest against tissue to be treated and to accommodate fluid set at a temperature range to affect the tissue at the site of interest; an assembly for directing the fluid set at the temperature range into the expandable member, the assembly having an input to introduce the fluid into the expandable member to circulate substantially along an entire length of the expandable member and an output spatially situated from the input to permit fluid flow to be removed from within the expandable member; and a mechanism designed to direct fluid along the assembly and through the input into the expandable member while simultaneously removing fluid from the expandable member through the output, so as to maintain substantially constant fluid pressure within the expandable member.

Abstract: Various types of otomy control devices that secure a periphery and/or adjacent tissue of a target otomy site and maintain the size of an otomy through a single wall of a vessel, organ, or lumen within the body. Among other things, this can reduce unintentional trauma, dilation, contraction, or locomotion of an otomy during a surgical procedure. They also can serve a beneficial purpose of allowing immediate communication between lumens before the complete creation of A permanent anastomosis. In some embodiments, magnetic compression anastomosis devices and/or other devices can be deployed through a channel of the otomy control device such as for deployment in a distal lumen.

Abstract: Methods and apparatuses for providing an adjustable flow resistor. The adjustable flow resistor can include a chamber into which fluid is introduced, having an input end and an output end. A flow modifier can be situated within the chamber, between the input end and the output end, to modify a flow rate of the fluid. An adjustable resistance member can be positioned to interact with the flow modifier within the chamber to controllably modify the constant flow rate out of the adjustable flow resistor.

Abstract: A surgical illumination apparatus comprises a fiber optic input, and illuminated surgical instrument, and an optical coupling bracket for coupling the fiber optic input to the illuminated surgical instrument. The coupling bracket comprises an elongate frame having a proximal end, a distal end, and a central channel extending therebetween, wherein the central channel is sized to receive and support optical fibers of the fiber optic input. The proximal end of the bracket is coupled to the fiber optic input, and the distal end of the bracket is coupled to an illumination element of the illuminated surgical instrument. The apparatus may further comprise a shroud disposed around the illumination element that is coupled to the bracket.

Abstract: The systems and methods of the present disclosure provides an independent passive variable resistor that can be interposed between a fluid reservoir at an inlet pressure and receptacle at an outlet pressure. The resistor can adjust resistance to the pressure difference from the input to the output so that the flow rate through it is a constant rate. The resistor can include a moveable element and a biasing mechanism located in a chamber to create a flow channel. Each side of the moveable element is exposed to the inlet and outlet pressures and moves within the flow channel to modify the resistance of the flow through the chamber in response to the pressures. The balance of these forces determines the position moveable element, which interacts with the fluid channel to determine the flow resistance through variable resistor. The biasing mechanism can provide the necessary pressure to establish equilibrium flow rate.

Abstract: A surgical illumination apparatus comprises a fiber optic input, and illuminated surgical instrument, and an optical coupling bracket for coupling the fiber optic input to the illuminated surgical instrument. The coupling bracket comprises an elongate frame having a proximal end, a distal end, and a central channel extending therebetween, wherein the central channel is sized to receive and support optical fibers of the fiber optic input. The proximal end of the bracket is coupled to the fiber optic input, and the distal end of the bracket is coupled to an illumination element of the illuminated surgical instrument. The apparatus may further comprise a shroud disposed around the illumination element that is coupled to the bracket.

Abstract: The systems and methods of the present disclosure provides an independent passive variable resistor that can be interposed between a fluid reservoir at an inlet pressure and receptacle at an outlet pressure. The resistor can adjust resistance to the pressure difference from the input to the output so that the flow rate through it is a constant rate. The resistor can include a moveable element and a biasing mechanism located in a chamber to create a flow channel. Each side of the moveable element is exposed to the inlet and outlet pressures and moves within the flow channel to modify the resistance of the flow through the chamber in response to the pressures. The balance of these forces determines the position moveable element, which interacts with the fluid channel to determine the flow resistance through variable resistor. The biasing mechanism can provide the necessary pressure to establish equilibrium flow rate.

Abstract: A surgical illumination apparatus comprises a fiber optic input, and illuminated surgical instrument, and an optical coupling bracket for coupling the fiber optic input to the illuminated surgical instrument. The coupling bracket comprises an elongate frame having a proximal end, a distal end, and a central channel extending therebetween, wherein the central channel is sized to receive and support optical fibers of the fiber optic input. The proximal end of the bracket is coupled to the fiber optic input, and the distal end of the bracket is coupled to an illumination element of the illuminated surgical instrument. The apparatus may further comprise a shroud disposed around the illumination element that is coupled to the bracket.

Abstract: Provided herein are methods and a device for collecting biological samples. In particular, the present disclosure relates to a device designed to specifically capture samples within the target areas of a patient for specific cell collection for particular diagnosis.

Abstract: A surgical illumination apparatus comprises a fiber optic input, and illuminated surgical instrument, and an optical coupling bracket for coupling the fiber optic input to the illuminated surgical instrument. The coupling bracket comprises an elongate frame having a proximal end, a distal end, and a central channel extending therebetween, wherein the central channel is sized to receive and support optical fibers of the fiber optic input. The proximal end of the bracket is coupled to the fiber optic input, and the distal end of the bracket is coupled to an illumination element of the illuminated surgical instrument. The apparatus may further comprise a shroud disposed around the illumination element that is coupled to the bracket.

Abstract: A surgical illumination apparatus comprises a fiber optic input, and illuminated surgical instrument, and an optical coupling bracket for coupling the fiber optic input to the illuminated surgical instrument. The coupling bracket comprises an elongate frame having a proximal end, a distal end, and a central channel extending therebetween, wherein the central channel is sized to receive and support optical fibers of the fiber optic input. The proximal end of the bracket is coupled to the fiber optic input, and the distal end of the bracket is coupled to an illumination element of the illuminated surgical instrument. The apparatus may further comprise a shroud disposed around the illumination element that is coupled to the bracket.

Abstract: Methods and systems for cell collection. Methods and systems include a collection mechanism being transformable between a collection state having an expanded diameter and a retrieval state where the diameter is less than that of the collection state and a conveyance mechanism having a distal end to which the collection mechanism is attached and designed to place the collection mechanism at a site of interest for cell collection. The Methods and systems also include an activation mechanism to transform the collection mechanism between the collection state and the retrieval state.

Abstract: A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state.

Abstract: A method for collecting a cell sample, including eosinophil white blood cells in a patient is provided. The method includes advancing to a location in an esophagus associated with eosinophilic esophagitis (EoE), a device provided with a collection portion having a first axial end portion and an inflatable second axial end portion. Thereafter, axially moving the second axial end portion, relative to the first axial end portion, from a collapsed position within the first axial end portion into an expanded position out from the first axial end portion. Once the second axial end portion is in the expanded position, allowing it to engage the location associated with EoE to collect a sample of cells.

Abstract: The present invention relates to a catheter construction and method of use suitable for use in navigating within a body lumen or vessel, such as a vein, artery, nasal cavity, esophagus, etc. to assist in the performance of various procedures. The device can include a flexible tubular member having a proximal end, a distal end, and channel extending substantially between the proximal end and the distal end, a stiffening sleeve positioned at the distal end of the tubular member to provide stiffness thereto so that a removable procedural tool can be attached to the tubular member, and an elongated non-elastic tether situated within the channel of the tubular member and secured at one end to the distal end of the member, such that when the tether is held in tension, the tether acts to minimize the tubular member from deviating from a neutral state.

Abstract: A surgical illumination apparatus comprises a fiber optic input, and illuminated surgical instrument, and an optical coupling bracket for coupling the fiber optic input to the illuminated surgical instrument. The coupling bracket comprises an elongate frame having a proximal end, a distal end, and a central channel extending therebetween, wherein the central channel is sized to receive and support optical fibers of the fiber optic input. The proximal end of the bracket is coupled to the fiber optic input, and the distal end of the bracket is coupled to an illumination element of the illuminated surgical instrument. The apparatus may further comprise a shroud disposed around the illumination element that is coupled to the bracket.

Abstract: The systems and methods of the present disclosure provides an independent passive variable resistor that can be interposed between a fluid reservoir at an inlet pressure and receptacle at an outlet pressure. The resistor can adjust resistance to the pressure difference from the input to the output so that the flow rate through it is a constant rate. The resistor can include a moveable element and a biasing mechanism located in a chamber to create a flow channel. Each side of the moveable element is exposed to the inlet and outlet pressures and moves within the flow channel to modify the resistance of the flow through the chamber in response to the pressures. The balance of these forces determines the position moveable element, which interacts with the fluid channel to determine the flow resistance through variable resistor. The biasing mechanism can provide the necessary pressure to establish equilibrium flow rate.