Abstract: An implantable medical device for bone repair following a loss of bone substance including a scaffold having a three-dimensional structure and having at least one polymer, a film having at least one protein from the Bone Morphogenetic Proteins (BMP) family, including the scaffold defines an internal volume having a three-dimensional mesh delimiting pores, the pores being open and interconnected, the largest dimension of each pore being greater than 200 µm, the scaffold having a minimum porosity of 80%, and in that the film coats the three-dimensional mesh. Also relates to the field of implantable medical devices. One application concerns the field of repairing bone following a loss of bone substance. The disclosure is applicable to large-volume bone defects ranging from 2 cm3 to 15 cm3.