Abstract: Techniques and systems are disclosed for performing mechanical ablation of blood clots using low-intensity ultrasound. A system includes a computed tomography (CT) scanner to acquire axial scans of a target subject containing at least one intravascular blood clot, and generate volumetric CT data of the target subject based on the acquired axial scans. A data processing device is in communication with the CT scanner to process the generated volumetric CT data, and identify at least one parameter of an ultrasound beam to ablate the at least one intravascular blood clot based on the processed volumetric CT data. Also, an ultrasound ablation device is in communication with the data processing device to generate the ultrasound beam based on the identified at least one parameter, and apply the generated ultrasound beam with the identified at least one parameter to ablate the at least one intravascular blood clot.