Abstract: Provided is a method to prepare a solid dispersion composition comprising an active pharmaceutical ingredient (API) and a pharmaceutically acceptable dispersion carrier, which includes (a) dissolving the API and the pharmaceutically acceptable dispersion carrier in a solvent to form a dissolved API/pharmaceutically acceptable dispersion carrier solution; and/or (b) combining the dissolved API/pharmaceutically acceptable dispersion carrier solution and an anti-solvent to form a combination, wherein the anti-solvent comprises a surfactant; and/or (c) mixing the combination to generate an emulsion with a predetermined mean particle size range; and/or (d) removing the solvent from the emulsion to generate the solid dispersion composition, wherein the solid dispersion composition has the predetermined mean particle size range. Preferably, the API in the solid dispersion composition is amorphous. Also provided is an emulsion and/or a solid dispersion composition comprising the API and a dispersion carrier.

Abstract: A blower assembly for a water heater includes a blower inlet shroud having an inlet opening and an outlet opening and a scroll housing defining an outer surface, an outlet, and a spiral feature. The scroll housing and the blower inlet shroud are connected to each other and define an inner volume. The blower inlet shroud outlet opening is fluidly connected to the scroll housing inner volume. The blower assembly further includes an impeller wheel positioned within the inner volume defined by the blower inlet shroud and the scroll housing. The impeller wheel is configured to move a fluid from the blower inlet shroud inlet opening to the scroll housing outlet opening.

Abstract: In various aspects and embodiments, the invention provides a nucleic acid molecule comprising a nucleotide sequence encoding a 7?-hydroxysteroid dehydrogenase (7?-HSDH) mutant that catalyzes at least the stereospecific enzymatic reduction of a 7-ketosteroid to the corresponding 7-hydroxysteroid, wherein the mutant has, compared to the wildtype 7?-HSDH of SEQ ID NO:2, a decreased substrate inhibition and/or an altered cofactor usage, and the mutant has, in comparison with the wildtype 7?-HSDH of SEQ ID NO:2, 1 to 15 amino acid additions, substitutions, deletions and/or inversions in the sequence motif VMVGRRE corresponding to positions 36 to 42 of SEQ ID NO:2.

Abstract: A steel material for a torsionally stressed component, such as a driveshaft, having a minimum tensile strength of 800 MPs, and the microstructure consists of more than 50 vol. % of bainite, having an alloy with the following composition in wt. %: C: 0.02 to 0.3; Si: up to 0.7; Mn: 1.0 to 3.0; P: max. 0.02; S: max. 0.01; N: max. 0.01; Al: up to 0.1; Cu: up to 0.2; Cr: up to 3.0; Ni: up to 0.3; Mo: up to 0.5; Ti: up to 0.2; V: up to 0.2; Nb: up to 0.1; B: up to 0.01; where 0.02?Nb+V+Ti?0.25, residual iron, and smelting impurities. The steel material is inexpensive and has good torsional fatigue strength when used for a torsionally stressed component. The invention also relates to a method for producing a component made of the material and to such a component.

Abstract: An off-road vehicle includes a frame coupled to one or more tractive elements, a cab supported on the frame, and a hood assembly coupled to the frame. The hood assembly includes a first hood coupled to the frame by a first hinge assembly and a second hood coupled to the frame by a second hinge assembly. The first hood is configured to pivot about the first hinge assembly independent of the second hood, and the second hood is configured to pivot about the second hinge assembly independent of the first hood.

Abstract: A vehicle includes a frame, a tractive element coupled to the frame, an engine coupled to the frame and configured to drive the tractive element, and a debris shield coupled to the frame. The debris shield at least partially defines at least one of a left side or a right side of an engine compartment containing the engine. The debris shield includes an outer frame coupled to the frame and defining a ventilation aperture, an inner frame coupled to the outer frame, and a screen extending across the ventilation aperture. The screen extends between the outer frame and the inner frame such that the inner frame limits movement of the screen relative to the outer frame.

Abstract: A test apparatus for testing a device under test, is configured to receive a pattern from the device under test, which comprises information from a plurality of functional blocks of the device under test. The test apparatus is configured to separate errors within the received pattern associated with different functional blocks of the device under test during an execution of a test program, or the test apparatus is configured to separate errors within the received pattern associated with different blocks of one or more bits during an execution of a test program. A method and a computer program are also described.

Abstract: The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and a partner drug, processes for the preparation thereof, and their use to treat certain diseases.

Abstract: A mounting system (10) for detachably mounting electronic devices in a motor vehicle, comprising a connecting section (12) for connection to the motor vehicle, with a first holder (30) connected to the connecting section, which first holder (30) has a first holding space (48) and first holding sections (42, 46) for holding a first electronic device (50), with a second holder (52) with a second holding space (54) for holding a second electronic device (56), wherein the second holder can be arranged or is arranged in the first holding space and can be detachably fixed or is detachably fixed to the first holding sections.

Abstract: The sealing arrangement includes a connecting device and one or more housing parts of a housing unit for enclosing of a component, typically an attachment component forming a head of the connecting device. The gas permeable end formed in such component can be isolated, so that the sealing arrangement is adapted for use in detecting a detectable gas in a hermetically sealed detection chamber. Thanks to a sealing structure configured at a passageway for the fastening of the connecting device, a housing unit is obtained with a tight radial contact around an intermediate portion of the connecting device. The device is fitted with a flexible hose end, preferably at a barbed nozzle forming the end at the opposite from the gas permeable end. With such arrangement, the hose mounting can be tested for its integrity.

Abstract: In various aspects and embodiments, the invention provides a nucleic acid molecule comprising a nucleotide sequence encoding a 7?-hydroxysteroid dehydrogenase (7?-HSDH) mutant that catalyzes at least the stereospecific enzymatic reduction of a 7-ketosteroid to the corresponding 7-hydroxysteroid, wherein the mutant has, compared to the wildtype 7?-HSDH of SEQ ID NO:2, a decreased substrate inhibition and/or an altered cofactor usage, and the mutant has, in comparison with the wildtype 7B-HSDH of SEQ ID NO:2, 1 to 15 amino acid additions, substitutions, deletions and/or inversions in the sequence motif VMVGRRE corresponding to positions 36 to 42 of SEQ ID NO:2.

Abstract: An off-road vehicle includes a frame coupled to one or more tractive elements, a cab supported on the frame, and a hood assembly coupled to the frame. The hood assembly includes a first hood coupled to the frame by a first hinge assembly and a second hood coupled to the frame by a second hinge assembly. The first hood is configured to pivot about the first hinge assembly independent of the second hood, and the second hood is configured to pivot about the second hinge assembly independent of the first hood.

Abstract: The sealing arrangement includes a connecting device and one or more housing parts of a housing unit for enclosing of a component, typically an attachment component forming a head of the connecting device. The gas permeable end formed in such component can be isolated, so that the sealing arrangement is adapted for use in detecting a detectable gas in a hermetically sealed detection chamber. Thanks to a sealing structure configured at a passageway for the fastening of the connecting device, a housing unit is obtained with a tight radial contact around an intermediate portion of the connecting device. The device is fitted with a flexible hose end, preferably at a barbed nozzle forming the end at the opposite from the gas permeable end. With such arrangement, the hose mounting can be tested for its integrity.

Abstract: In various aspects and embodiments, the invention provides a nucleic acid molecule comprising a nucleotide sequence encoding a 7?-hydroxysteroid dehydrogenase (7?-HSDH) mutant that catalyzes at least the stereospecific enzymatic reduction of a 7-ketosteroid to the corresponding 7-hydroxysteroid, wherein the mutant has, compared to the wildtype 7?-HSDH of SEQ ID NO:2, a decreased substrate inhibition and/or an altered cofactor usage, and the mutant has, in comparison with the wildtype 7?-HSDH of SEQ ID NO:2, 1 to 15 amino acid additions, substitutions, deletions and/or inversions in the sequence motif VMVGRRE corresponding to positions 36 to 42 of SEQ ID NO:2.

Abstract: A tool for installing a door striker pin. The tool includes a latch portion, a pin positioning portion, and a cover. The latch portion includes a striker pin configured to engage with a latch of a door and an abutment surface configured to engage with a frame member of a cab. The pin positioning portion is coupled to the latch portion. The pin positioning portion defines a striker pin slot extending substantially parallel with the striker pin. The striker pin slot is positioned to align with a striker pin interface for the door. The cover is slidably coupled to the pin positioning portion such that the cover is slidably translatable between a first position where the cover extends across the striker pin slot and a second position where the cover does not extend across the striker pin slot.

Abstract: A vehicle includes a frame, a tractive element coupled to the frame, an engine coupled to the frame and configured to drive the tractive element, and a debris shield coupled to the frame. The debris shield at least partially defines at least one of a left side or a right side of an engine compartment containing the engine. The debris shield includes an outer frame coupled to the frame and defining a ventilation aperture, an inner frame coupled to the outer frame, and a screen extending across the ventilation aperture. The screen extends between the outer frame and the inner frame such that the inner frame limits movement of the screen relative to the outer frame.

Abstract: The invention relates to a motor vehicle seat assembly (10), having motor vehicle seat (12) and having at least one accessory (48) that can be fastened releasably to the motor vehicle seat, wherein the motor vehicle seat has a receiving bushing with insertion opening (30) for the releasable fastening of the accessory, and wherein the accessory has plug-in part (42) that can be inserted into the insertion opening of the receiving bushing, wherein the motor vehicle seat has at least one additional receiving bushing that is arranged offset with respect to the receiving bushing and has additional insertion opening (32), and wherein the insertion opening and the additional insertion opening are assigned insertion directions for plug-in part (44) and for the additional plug-in part that are parallel to one another and are directed in the same direction.

Abstract: A tool for installing a door striker pin includes: a latch engagement section having a first surface, a striker pin extending from the first surface, and an abutment surface that extends generally orthogonal to the first surface; and a pin positioning section coupled to the latch engagement section and including a positioning surface with a striker pin slot formed therethrough that extends in parallel with the striker pin. The striker pin slot is positioned in the positioning surface such that the striker pin slot is aligned with a striker pin installation location when the striker pin of the latch engagement section is engaged with a latch of a door and the abutment surface rests against a frame to which the door is pivotably coupled.

Abstract: The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and a partner drug, processes for the preparation thereof, and their use to treat certain diseases.

Abstract: An adapter for a liquid container of a supply system of a wet process module for the treatment of substrates has a container part for fastening to the liquid container and a channel part for fastening to the supply system. The container part has a central opening and a fastening device for fastening the container part to the liquid container. The channel part has a continuous first channel portion and a continuous second channel portion, the first and the second channel portion each opening into the central opening of the container part.