Abstract: A niobium-silicide based alloy and a turbine having at least a turbine component formed from the niobium-silicide based alloy are provided. The niobium-silicide based alloy comprises: between about 14 atomic percent and about 24 atomic percent titanium (Ti); between about 11 atomic percent and about 19 atomic percent silicon (Si); between about 4 atomic percent and about 8 atomic percent chromium (Cr); between about 2 atomic percent and about 6 atomic percent hafnium (Hf); up to about 4 atomic percent aluminum (Al); between about 0.5 atomic percent and about 1 atomic percent tin (Sn); between about 5 atomic percent and about 15 atomic percent tantalum (Ta); between about 1 atomic percent and about 5 atomic percent tungsten (W); up to about 5 atomic percent rhenium (Re); up to about 5 atomic percent zirconium (Zr); up to about 6 atomic percent yttrium (Y); and a balance of niobium (Nb).

Abstract: A produce wash system is provided. The produce wash system includes a produce line including a short-term wash device and a rinse transition component followed by a wash device, a short-term wash treatment that is applied by the short-term wash device to a product, wherein the short-term wash treatment remains on the product for a pretreatment time that lasts until the short-term wash treatment is rinsed off, and a rinse solution applied by the rinse transition component that rinses the product after the product leaves the short-term wash device and before the product enters the wash device, and a wash treatment that is applied by the wash device to the product, wherein the wash treatment rinses any remaining short-term wash treatment from the product. The pretreatment time is set at or below a damage threshold time beyond which the short-term wash treatment damages the product beyond a damage threshold.

Abstract: A system and method provides transparency in an artificial intelligence based model. A talent data block reduces bias influencers, an algorithm block coupled to the talent data block provides time-stamped data; and a decisions block coupled to the talent data and algorithm blocks allows auditing of decisions using the time-stamped data.

Abstract: A friction stir additive manufacturing device configured to join a first work-piece and a second work-piece is provided. In one aspect, the device includes a rotating spindle configured to deposit a filler material over a weld line as the device is advanced along an interface between the first work-piece and the second work-piece. The device also includes a deposition head configured to receive at least a portion of the spindle, the deposition head configured to remain stationary relative to the rotating spindle. The deposition head includes a first semi-cylindrical portion having an inner radius and an outer radius relative to a first axis, and a second semi-cylindrical portion having an inner radius and an outer radius relative to a second axis that is perpendicular to the first axis. The second semi-cylindrical portion can include a chamfered inner surface configured to define a weld profile.

Abstract: The present embodiments relate to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease. Particular compounds described herein exhibit selective inhibitory activity against CBP compared with BRD4.

Abstract: The utilization of the byproducts from the deacetylation of lignocellulosic biomass from the production of ethanol to create cement additives and/or alternatives to ordinary portland cement (OPC) is described. These byproducts may be used to create black liquor bioash (BLA), activated lignin carbon (ALC), and/or lignin aerogel admixtures. In some embodiments, the byproduct may be combined with at least one binder to form alkali-activated materials (AAMs).

Abstract: A niobium-silicide based alloy and a turbine having at least a turbine component formed from the niobium-silicide based alloy are provided. The niobium-silicide based alloy comprises: between about 14 atomic percent and about 24 atomic percent titanium (Ti); between about 11 atomic percent and about 19 atomic percent silicon (Si); between about 4 atomic percent and about 8 atomic percent chromium (Cr); between about 2 atomic percent and about 6 atomic percent hafnium (Hf); up to about 4 atomic percent aluminum (Al); between about 0.5 atomic percent and about 1 atomic percent tin (Sn); between about 5 atomic percent and about 15 atomic percent tantalum (Ta); between about 1 atomic percent and about 5 atomic percent tungsten (W); up to about 5 atomic percent rhenium (Re); up to about 5 atomic percent zirconium (Zr); up to about 6 atomic percent yttrium (Y); and a balance of niobium (Nb).

Abstract: The present embodiments relate to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease. Particular compounds described herein exhibit selective inhibitory activity against CBP compared with BRD4.

Abstract: The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for modulating the activity of histone demethylase enzymes. Additionally, the subject compounds and compositions are useful for the treatment of cancer or other neoplastic diseases, or maladies associated with abnormal histone demethylase activity. Accordingly, the substituted triazolylpyridine derivative compounds described herein are useful in methods and medicaments for treating cancer.

Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Abstract: Compositions comprise a perovskite and a non-perovskite. Perovskites comprise AxA?yA?(1?x?y)BX3, and non-perovskites may comprise A?, B and X, where A is a first cation, A? is a second cation, A? is a third cation, B is a fourth cation, X is an anion. In some instances, A, A?, and A? are each independently (NH2)2CH+, CH3NH3+, Cs+, Rb+, or (NH2)2(C?NH2)+, with the proviso that A, A?, and A? are each different. The perovskite may have a first crystal structure in which the anion is corner-sharing, the non-perovskite may have a second crystal structure comprising at least one of an orthorhombic structure, a hexagonal structure, or a perovskite-like structure, and 1?x?y may be greater than about 0.15.

Abstract: The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds, and compositions (including pharmaceutical compositions) that include these compounds. The subject compounds and compositions are useful for inhibition of at least one histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer or neoplastic disease, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, retinoblastoma, or multiple endocrine neoplasia type 1.

Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Abstract: Described herein are cementitious compositions comprising biochar and methods of making such compositions. The compositions find use in a variety of applications, including use in a variety of building materials and building applications.

Abstract: Various embodiments that pertain to a loop antenna are described. The loop antenna can be a single loop antenna that switches between a first phase and a second phase. While operating at different phases, the loop antenna can function at the same frequency. The loop antenna can observe a response to the frequency at the first phase and the frequency at the second phase. This can provide a wider range of information over operation in a single phase.

Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Abstract: Various embodiments that pertain to a loop antenna are described. The loop antenna can be a single loop antenna that switches between a first phase and a second phase. While operating at different phases, the loop antenna can function at the same frequency. The loop antenna can observe a response to the frequency at the first phase and the frequency at the second phase. This can provide a wider range of information over operation in a single phase.

Abstract: The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds, and compositions (including pharmaceutical compositions) that include these compounds. The subject compounds and compositions are useful for inhibition of at least one histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer or neoplastic disease, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, retinoblastoma, or multiple endocrine neoplasia type 1.