Abstract: The present invention relates to methods, uses, and compositions for the treatment of cancer (e.g., a breast cancer or a pancreatic cancer). More specifically, the invention concerns the treatment of patients having cancer for the therapeutic inhibition of cancer cell growth and metastasis with an anti-Cadherin 11 monoclonal antibody with specific monoclonal antibody clones 23C6 or 3H10.

Abstract: The present invention relates to methods, uses, and compositions for the treatment of cancer (e.g., a breast cancer or a pancreatic cancer). More specifically, the invention concerns the treatment of patients having cancer for the therapeutic inhibition of cancer cell growth and metastasis with an anti-Cadherin 11 monoclonal antibody with specific monoclonal antibody clones 23C6 or 3H10.

Abstract: Example embodiments relate to machine-learned approximation techniques for numerical simulations. An example computer-implemented method for performing enhanced numerical simulations includes receiving a first vector field corresponding to a first solution of one or more differential equations at a first time step. The first vector field includes first values at each of a plurality of points along a mesh. The method also includes determining, using a machine-learned model, one or more refinement terms based on the first vector field, wherein the refinement terms represent effects of areas between points on the mesh. In addition, the method includes modifying one or more of the first values at one or more of the plurality of points along the mesh based on the one or more refinement terms. Further, the method includes generating a second vector field that includes second values at each of the plurality of points.

Abstract: Methods of promoting or inhibiting weight loss by modulating activity or levels of ?? T cells.

Abstract: Methods of promoting or inhibiting weight loss by modulating activity levels of ?? T cells.

Abstract: A modular post anchor device is placed in the ground to hold and support a post as part of a fence. The device is held in the ground by a horizontal anchor. The device attaches to the post via a vertical support. The post is secured by fasteners or the like.

Abstract: The present application relates to methods and compositions for detecting thyroid cancer in mammals, in particular in humans. The invention provides novel biomarkers which, in combination, allow effective, specific and sensitive detection of thyroid cancer, particularly to assist in the diagnosis of thyroid lesions in human subjects. The invention further relates to tools and/or kits (such as reagents, probes, primers, chips or arrays) suitable for implementing said methods, and the preparation and uses thereof.

Abstract: A shelf guard 20 comprises at least one protective member 22 having at least an inner-facing (i.e. towards a support structure 40) surface 23 and at least one mounting member 24 having at least an inner-facing surface 27 that are preferably both made from a transparent and substantially rigid material, such as plastic or acrylic. An attachment element 30 (such as an adhesive strip or double sided tape) is included on the inner-facing surface 27 of at least one mounting member 24 to secure the shelf guard 20 to a shelf 40 by adhering to the shelf's underside surface 44 with the inner-facing surface 23 of the at least one protective member 22 extending upwardly from the edge of the support structure 40 to define an upwardly extending protective wall along the edge, thereby preventing objects stored on a surface of the support structure 40 from falling off the edge of the support structure 40.

Abstract: A shelf guard 20 comprises at least one protective member 22 having at least an inner-facing (i.e. towards a support structure 40) surface 23 and at least one mounting member 24 having at least an inner-facing surface 27 that are preferably both made from a transparent and substantially rigid material, such as plastic or acrylic. An attachment element 30 (such as an adhesive strip or double sided tape) is included on the inner-facing surface 27 of at least one mounting member 24 to secure the shelf guard 20 to a shelf 40 by adhering to the shelf's underside surface 44 with the inner-facing surface 23 of the at least one protective member 22 extending upwardly from the edge of the support structure 40 to define an upwardly extending protective wall along the edge, thereby preventing objects stored on a surface of the support structure 40 from falling off the edge of the support structure 40.

Abstract: A process of diminishing the concentration of a transition metal complex from a first solution by adding a solubility-enhancing compound that enhances the solubility of said complex in a second solution and extracting the first solution with the second solution. The solubility-enhancing compound is a compound of formula A wherein, Ra is SH, SO3H, OH or COOH; Rb is SH, OH or COOH; Rc each independently is H, SH, OH or COOH; Rd each independently is H or COOH; n is 1, 2, 3, 4 or 5; or a salt or an activated form thereof.

Abstract: Genes and variant RNAs that are differentially expressed in human colon tumor tissues compared with normal colon tissue and the corresponding proteins are identified. These genes and the corresponding antigens are suitable targets for the treatment, diagnosis or prophylaxis of colon cancer.

Abstract: A lubricant composition with a total nitrogen content of 0.1 to 0.25 percent by weight suitable for lubricating a two-stroke engine comprising an oil of lubricating viscosity, a synthetic ester, at least one condensation product of a fatty acid having 12 to 24 carbon atoms with a polyamine, and a Mannich dispersant.

Abstract: The present invention is directed to pharmaceutical compositions that can be used to immunize subjects using, for example, lipid, glycan, or nucleic acid antigens. These antigens are conjugated to a glycosphingolipid.

Abstract: A method of planarizing a layer of an integrated circuit. In one embodiment, a liquid film is applied over the layer, using extrusion coating techniques. In another embodiment, the layer itself may be applied as a liquid film, using extrusion techniques.

Abstract: The present invention is directed to pharmaceutical compositions that contain a combination of apolipoprotein E and an antigenic lipid. The compositions may be administered to a subject for the purpose of inducing an immune response against the lipid and in immunization protocols.

Abstract: A process for diminishing the concentration of a metal complex from a solution containing said complex by the addition of an optionally fused and/or optionally substituted heterocyclic compound. The added compound is a solubility-enhancing compound that enhances the solubility of said complex in a second solution. Thereafter the solution containing said complex can be extracted with the second solution.

Abstract: A method for treating inflammatory joint diseases by inhibiting cadherin-11 mediated cellular function using a cadherin-11 modulating agent is provided. Also provided are screening assays for identifying pharmaceutical lead compounds capable of modulating cellular functions of cadherin-11 such as cell proliferation, apoptosis, factor secretion, and binding of cadherin-11 to cadherin-11 counter-receptor inhibiting binding of cadherin-11 to its counter-receptor either in the context of a cell or in soluble form.

Abstract: A process of diminishing the concentration of a transition metal complex from a first solution by adding a solubility-enhancing compound that enhances the solubility of said complex in a second solution and extracting the first solution with the second solution. The solubility-enhancing compound is a compound of formula A wherein, Ra is SH, SO3H, OH or COOH; Rb is SH, OH or COOH; Rc each independently is H, SH, OH or COOH; Rd each independently is H or COOH; n is 1, 2, 3, 4 or 5; or a salt or an activated form thereof.

Abstract: A process for diminishing the concentration of a metal complex from a solution containing said complex by the addition of an optionally fused and/or optionally substituted heterocyclic compound. The added compound is a solubility-enhancing compound that enhances the solubility of said complex in a second solution. Thereafter the solution containing said complex can be extracted with the second solution.

Abstract: A method of planarizing a layer of an integrated circuit. In one embodiment, a liquid film is applied over the layer, using extrusion coating techniques. In another embodiment, the layer itself may be applied as a liquid film, using extrusion techniques.