Patents by Inventor Michael Bruckman
Michael Bruckman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11730833Abstract: An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed.Type: GrantFiled: November 9, 2021Date of Patent: August 22, 2023Assignee: CASE WESTERN UNIVERSITYInventors: Nicole F. Steinmetz, Michael Bruckman, Lauren Randolph
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Patent number: 11654204Abstract: A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.Type: GrantFiled: June 1, 2021Date of Patent: May 23, 2023Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Nicole Steinmetz, Michael Bruckman
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Publication number: 20220211881Abstract: An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed.Type: ApplicationFiled: November 9, 2021Publication date: July 7, 2022Inventors: Nicole F. Steinmetz, Michael Bruckman, Lauren Randolph
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Publication number: 20220088228Abstract: A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.Type: ApplicationFiled: June 1, 2021Publication date: March 24, 2022Inventors: Nicole Steinmetz, Michael Bruckman
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Patent number: 11167047Abstract: An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed.Type: GrantFiled: February 19, 2019Date of Patent: November 9, 2021Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Nicole F. Steinmetz, Michael Bruckman, Lauren Randolph
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Patent number: 11020497Abstract: A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.Type: GrantFiled: October 2, 2018Date of Patent: June 1, 2021Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Nicole Steinmetz, Michael Bruckman
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Patent number: 10928352Abstract: A system can facilitate detection of the presence of an analyte or a contaminant in a contaminated sample. The system includes a first sensor to detect the analyte and a contaminant in the sample and a second sensor to detect the analyte or the contaminant in the sample. The detections are compared by a device comprising a processor to eliminate either the analyte or the contaminant from the final detected result.Type: GrantFiled: October 30, 2018Date of Patent: February 23, 2021Inventors: Seyamak Keyghobad, Michael Bruckman, Eve F. Fabrizio, Bindi Patel
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Publication number: 20200384131Abstract: An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed.Type: ApplicationFiled: February 19, 2019Publication date: December 10, 2020Inventors: Nicole F. Steinmetz, Michael Bruckman, Lauren Randolph
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Publication number: 20200333281Abstract: A system can facilitate detection of the presence of an analyte or a contaminant in a contaminated sample. The system includes a first sensor to detect the analyte and a contaminant in the sample and a second sensor to detect the analyte or the contaminant in the sample. The detections are compared by a device comprising a processor to eliminate either the analyte or the contaminant from the final detected result.Type: ApplicationFiled: October 30, 2018Publication date: October 22, 2020Inventors: Seyamak KEYGHOBAD, Michael BRUCKMAN, Eve F. FABRIZIO, Bindi PATEL
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Patent number: 10207014Abstract: An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed.Type: GrantFiled: March 27, 2018Date of Patent: February 19, 2019Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Nicole F. Steinmetz, Michael Bruckman, Lauren Randolph
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Publication number: 20190030193Abstract: A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.Type: ApplicationFiled: October 2, 2018Publication date: January 31, 2019Inventors: Nicole Steinmetz, Michael Bruckman
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Patent number: 10086095Abstract: A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.Type: GrantFiled: October 9, 2013Date of Patent: October 2, 2018Assignee: Case Western Reserve UniversityInventors: Nicole Steinmetz, Michael Bruckman
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Publication number: 20180256758Abstract: An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed.Type: ApplicationFiled: March 27, 2018Publication date: September 13, 2018Inventors: Nicole F. Steinmetz, Michael Bruckman, Lauren Randolph
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Patent number: 9925281Abstract: An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed.Type: GrantFiled: August 5, 2015Date of Patent: March 27, 2018Assignee: Case Western Reserve UniversityInventors: Nicole F. Steinmetz, Michael Bruckman, Lauren Randolph
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Publication number: 20160045624Abstract: An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed.Type: ApplicationFiled: August 5, 2015Publication date: February 18, 2016Inventors: Nicole F. Steinmetz, Michael Bruckman, Lauren Randolph
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Patent number: 8831386Abstract: Protein scaffolds from tobacco mosaic virus coat protein modified to incorporate polyhistidine can bind to a metal or a dye while having improved self-assembly characteristics. The scaffold can take the form of tubes or disks, and can further be formed into dual plasmonic ring resonators. Such self-assembled structures provide useful optical properties.Type: GrantFiled: January 12, 2012Date of Patent: September 9, 2014Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Banahalli R. Ratna, Amy S. Blum, Carissa M. Soto, Michael A. Bruckman, Jinny Lin Liu, Ronald W. Rendell, James Peter Long, Ronald J. Tonucci
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Publication number: 20130181171Abstract: Protein scaffolds from tobacco mosaic virus coat protein modified to incorporate polyhistidine can bind to a metal or a dye while having improved self-assembly characteristics. The scaffold can take the form of tubes or disks, and can further be formed into dual plasmonic ring resonators. Such self-assembled structures provide useful optical properties.Type: ApplicationFiled: January 12, 2012Publication date: July 18, 2013Inventors: Banahalli R. Ratna, Amy S. Blum, Carissa M. Soto, Michael A. Bruckman, Jinny Lin Liu, Ronald W. Rendell, James Peter Long, Ronald J. Tonucci