Abstract: The present disclosure is related to a method of producing a microfluidic sorting apparatus. The method includes providing an injection-molded substrate comprising a network of channels; bonding an insulating film to an upper surface of the substrate to cover the network of channels; and depositing a conductive film on the insulating film. The substrate can be separated from the conductive film.

Abstract: Methods and systems are provided to facilitate simultaneous high-resolution microscopic imaging of cells and detection of side-scattered light from such cells using an immersion objective. A container maintains a volume of an immersion oil or other immersion fluid in contact with the immersion objective and with a stage that contains a sample of the cells. The container also includes a window through which the cells can be illuminated off-axis to generate side-scattered light. The side-scattered light can then be detected through the immersion objective. The container maintains the immersion fluid in contact with an internal surface of the window to control the geometry of the optical interface between the off-axis illumination source and the immersion fluid. These systems permit high-throughput identification and imaging of cells for biological research, improvement of side-scatter cell classifiers, improved high-throughput cell sorting, and other applications.

Abstract: Systems and methods for sorting particles are described. In one implementation, a system for sorting particles include a microfluidic device, a detection system, and an optical switching system. The microfluidic device includes a sample channel for passing through the particles in a fluid medium, a plurality of output channels fluidly connected to the sample channel at a plurality of junctions, and an actuation channel. The detection system detects a particle passing through the sample channel. The optical switching system deflects the particle to a target output channel based on results detected by the detection system. The optical switching system includes a modulation device configured to direct a laser pulse to an actuation region in the actuation channel corresponding to the target output channel. Advantageously, the systems and methods allow for accurate and dynamic sorting of a mixture of cells into a plurality of subpopulations using a simple microfluidic device.

Abstract: Various embodiments are included for adjusting a search result user interface when a foreign language search query is detected. A search query associated with a search request is obtained. A language of the search query is identified. Search results are obtained from a site corresponding to the language. Additionally, a translation of the search query is obtained if allowed for a corresponding product category.

Abstract: Disclosed are various embodiments of adjusting a search result user interface when a foreign language search query is detected. A search query associated with a search request is obtained. A language of the search query is identified. Search results are obtained from a site corresponding to the language. Additionally, a translation of the search query is obtained if allowed for a corresponding product category.

Abstract: Various embodiments for adjusting a search result user interface when a foreign language search query is detected. A search query associated with a search request is obtained. A language of the search query is identified. An search result user interface is generated using a foreign language template when the language varies from an expected language. The search result user interface includes results based on the foreign language search query.

Abstract: Wearable devices configured to detect the presence, concentration, number, or other properties of nanoparticles disposed in subsurface vasculature of a person are provided. The wearable devices are configured to magnetize the nanoparticles at an upstream location of subsurface vasculature and to detect, using a magnetometer, magnetic fields produced by the magnetized nanoparticles at a downstream location of subsurface vasculature. In some embodiments, the nanoparticles are configured to bind to an analyte of interest and detected properties of the magnetized nanoparticles can be used to determine the presence, concentration, or other properties of the analyte.

Abstract: Disclosed are various embodiments of adjusting a search result user interface when a foreign language search query is detected. A search query associated with a search request is obtained. A language of the search query is identified. An alternative search result user interface is generated when the language varies from an expected language. Additionally, an alternative search query can be generated that is based at least in part upon the originally submitted search query.

Abstract: Disclosed are various embodiments of adjusting a search result user interface when a foreign language search query is detected. A search query associated with a search request is obtained. A language of the search query is identified. An alternative search result user interface is generated when the language varies from an expected language. Additionally, an alternative search query can be generated that is based at least in part upon the originally submitted search query.

Abstract: An optimizer/normalizer is used to generate optimized intermediate language representation of an input query, such as an XML input query. A method of optimization of an input query in intermediate language form includes receiving the input query, examining the nodes in a left-depth first manner to identify code patterns and node types which are subjects for optimization, tagging the identified code patterns until the intermediate language representation of the input query has been examined in its entirety, searching from the top of the intermediate language representation for tagged code patterns, and adjusting the tagged code patterns with improved code patterns to form an optimal representation for an input query. The input to the optimizer/normalizer is assumed to be an input query transformed into an intermediate language representation containing code patterns and nodes, each node having a respective node type.