Abstract: The disclosure relates to a medical implant for treating aneurysms, including a support structure, which has a compressible and expansible lattice structure lattice elements that define lattice openings, wherein the lattice structure is covered at least in part with an in particular electrospun membrane of fibres, which membrane includes at least one luminal functional layer and at least one abluminal protective layer, which each have pores, wherein the porosity of the functional layer is less than the porosity of the protective layer. The membrane is so configured that at least the pores of the functional layer open, as a result of a pressure gradient arising between a liquid pressure in an inner through channel of the support structure and a liquid pressure outside the protective layer, so as to increase the throughflow of liquid through the membrane.

Abstract: The disclosure relates to a stent with a compressible and expandable mesh structure of webs which are interconnected by web connectors into one piece and define rhomboid cells, wherein each cell is defined by two straight webs and two S-shaped curved webs which connect the straight webs together, and wherein (i) in a non-operational state, the mesh structure has a fully expanded non-operational diameter Dexp which is between 3.0 mm and 5.0 mm, (ii) a ratio between a fully compressed diameter Dkomp of the mesh structure and the non-operational diameter Dexp of the mesh structure is between 1:7 and 1:12, and (iii) the webs have a web height, measured in a radial direction, which is at least 0.05 mm and at most 0.09 mm, so that the mesh structure has a radial force of at least 0.5 N, in particular at least 0.6 N, between the fully compressed diameter Dkomp and an operational diameter which is at most 90% of the non-operational diameter Dexp.

Abstract: The disclosure relates to a medical system for treating stenosis in intracranial blood vessels including a compressible and self-expandable implant for covering the stenosis, said implant having a lattice structure, at least some sections of which are provided with a cover made of an electrospun fabric, wherein the fabric has irregularly sized pores, and a balloon catheter for dilating the stenosis and/or introducing the implant into the blood vessel.

Abstract: The disclosure relates to a medical kit for the treatment of vascular malformations, in particular aneurysms and/or fistulas, having a permanently implantable covering device, in particular a stent, for covering the vascular malformation, the covering device having a tubular, self-expandable lattice structure and a covering made of an electrospun fabric, the covering being connected to the lattice structure and overlapping the lattice structure at least in part such that, when implanted, the covering is placed over the vascular malformation; and an embolisation means, which can be applied by a feed means in the implanted state for treatment of the vascular malformation, the covering forming a porous membrane which can be penetrated by the feed means for application of the embolisation means and which is designed to lie against the outer periphery of the feed means in the penetrated state.

Abstract: The invention relates to a medical kit for the treatment of aneurysms, including a main catheter and a cover device for temporarily covering as aneurysm, which cover device can be moved through the main catheter to a place of treatment. The cover device includes a self-expanding lattice structure that has a cylindrical portion, open at a distal end and at least partially provided with a cover, and a funnel-type portion that is permanently connected to a transport wire, movable inside the main catheter, and a total lateral area of which is not covered so that when the lattice structure is expanded, blood can flow through it in the direction of its longitudinal axis. The invention further relates to a medical system.

Abstract: The invention relates to a medical set for treating aneurysms, including a main catheter and a covering device which can be moved through the main catheter to a treatment site and is intended to cover an aneurysm. The covering device is connected or can be connected to a transporting wire and includes a self-expandable grid structure made up of webs that are connected to one another in one piece and delimit inner cells and outer cells. The outer cells form at one longitudinal end of the grid structure a closed outer-cell ring, which is connected only on one side to inner cells. The grid structure is provided with a covering made of a fabric which has pores of irregular sizes, wherein at least one inner cell of the grid structure is at least partially, in particular mostly, free from the covering. A production process and a medical system are also provided.

Abstract: The invention relates to a medical device for treating aneurysms, in particular a stent, including a compressible and expandable grid structure made up of grid elements. The grid structure has at least one closed cell ring which includes at most 12, in particular at most 10, in particular at most 8, in particular at most 6 cells directly adjacent to one another in a circumferential direction of the grid structure. The grid structure is provided at least in certain portions with a covering made of an electrospun fabric which has pores of irregular sizes. The covering includes over a surface area of 100 000 ?m2 at least 10 pores which have a size of at least 15 ?m2. The covering has a biocompatible, in particular antithrombogenic and/or endothelialization-promoting coating.

Abstract: A medical device for inserting into a hollow organ of the body, said medical device having a compressible and expandable lattice structure made of webs, which are integrally connected to each other by web connectors and which bound closed cells of the lattice structure, wherein the web connectors each have a connector axis extending between two cells which, in a longitudinal direction of the lattice structure, are adjacent to each other. During the transition of the lattice structure from the production state to a compressed state, the web connectors rotate in such a way that an angle between the connector axis and a longitudinal axis of the lattice structure changes, in particular increases, during the transition of the lattice structure from a completely expanded production state to a partially expanded intermediate state.

Abstract: A medical catheter for hypothermic treatment with a catheter tube has at least one through-channel and at least two temperature control channels, at least one heat exchange element, in particular an expandable balloon, which is arranged in a distal catheter portion of the catheter tube and is fluidically connected to the temperature control channels in such a way that a temperature control circuit is formed. The catheter tube has a smaller external diameter in the distal catheter portion than in a proximal catheter portion.

Abstract: A medical catheter for hypothermic treatment has a catheter tube, which has at least two inner lumina. At least one inner lumen forms a temperature control duct that is suitable for in particular provided for, conveying a cooling liquid. A reinforcement is associated with at least one inner lumen.

Abstract: A balloon catheter for the endovascular temperature control of blood, with a catheter tube and at least one heat exchanger balloon which is convertible from an expanded operational state into a compressed insertion state. A temperature-control fluid can flow through the heat exchanger balloon, wherein the catheter tube includes at least one occlusion balloon which is arranged in series with the heat exchanger balloon.

Abstract: The application relates to a medical catheter for hypothermic treatment, with a catheter tube (10), which has at least one through-channel (11) and at least two temperature control channels (12, 13), and with at least one heat exchange element (14), in particular an expandable balloon, which is arranged in a distal catheter portion (15) of the catheter tube (10) and is fluidically connected to the temperature control channels (12, 13) in such a way that a temperature control circuit is formed. The application is characterized in that the catheter tube (10) has a smaller external diameter in the distal catheter portion (16) than in a proximal catheter portion (15).

Abstract: The present invention relates to a method of treating or preventing a disease characterized by excessive Wnt signalling, such as colorectal cancer, by administering a compound which inhibits the activity of one or more of JAK2, JAK1 or TYK2.

Abstract: The present invention relates generally to a method for detecting abnormalities or a propensity for an abnormality to occur in an animal such as a human. The abnormality of the present invention relates generally to conditions arising from interruption in signalling associated with receptor-type tyrosine kinase-like molecules and in particular RYK (related to tyrosine kinase) receptors. Such abnormalities include aberrations in the normal morphogenesis of craniofacial structures including secondary palate as well as a range of aberrations resulting in neural conditions affecting angiogenesis and conditions affecting muscle development or maintenance. The present invention permits the early diagnosis of such defects and conditions such as in utero and provides a means for genetic or other therapeutic intervention.