Abstract: The disclosure relates to a stent with a compressible and expandable mesh structure of webs which are interconnected by web connectors into one piece and define rhomboid cells, wherein each cell is defined by two straight webs and two S-shaped curved webs which connect the straight webs together, and wherein (i) in a non-operational state, the mesh structure has a fully expanded non-operational diameter Dexp which is between 3.0 mm and 5.0 mm, (ii) a ratio between a fully compressed diameter Dkomp of the mesh structure and the non-operational diameter Dexp of the mesh structure is between 1:7 and 1:12, and (iii) the webs have a web height, measured in a radial direction, which is at least 0.05 mm and at most 0.09 mm, so that the mesh structure has a radial force of at least 0.5 N, in particular at least 0.6 N, between the fully compressed diameter Dkomp and an operational diameter which is at most 90% of the non-operational diameter Dexp.

Abstract: The present invention relates to a method of treating or preventing a disease characterized by excessive Wnt signalling, such as colorectal cancer, by administering a compound which inhibits the activity of one or more of JAK2, JAK1 or TYK2.

Abstract: The present invention relates generally to a method for detecting abnormalities or a propensity for an abnormality to occur in an animal such as a human. The abnormality of the present invention relates generally to conditions arising from interruption in signalling associated with receptor-type tyrosine kinase-like molecules and in particular RYK (related to tyrosine kinase) receptors. Such abnormalities include aberrations in the normal morphogenesis of craniofacial structures including secondary palate as well as a range of aberrations resulting in neural conditions affecting angiogenesis and conditions affecting muscle development or maintenance. The present invention permits the early diagnosis of such defects and conditions such as in utero and provides a means for genetic or other therapeutic intervention.