Abstract: A packaging assembly includes a container body defining an interior for housing a product and an opening leading to the interior. The assembly further includes a cap that moves with respect to the container body to move the assembly between a closed position in which the cap covers the opening, and an opened position in which the opening is exposed. A first seal (40) is defined between the container body and the cap. The first seal includes a protrusion (42) formed on one of the container body about the opening or the cap, and a groove (44) formed on the other of the container body about the opening or the cap. The protrusion is received by the groove when the assembly is in the closed position, such that contact is maintained in a sealing relationship around the opening between the groove and the protrusion.

Abstract: Disclosed is a vial having an external base and an external sidewall extending up from the external base. The external sidewall narrows at an upper section of the vial to form a neck. The neck leads to a rim surrounding an opening providing access to a product compartment. The external base, the external sidewall, the neck and optionally the rim together define an outer profile of the vial. The outer profile is preferably round and symmetrical about a central axis. The vial further includes an internal sidewall that is spaced radially inward relative to the external sidewall such that a void exists between the internal sidewall and the external sidewall. The internal sidewall preferably extends from an internal portion of the neck, downward to an internal base. The internal sidewall and internal base form an enclosure that defines the product compartment.

Abstract: A packaging assembly includes a container body defining an interior for housing a product and an opening leading to the interior. The assembly further includes a cap that moves with respect to the container body to move the assembly between a closed position in which the cap covers the opening, and an opened position in which the opening is exposed. A first seal (40) is defined between the container body and the cap. The first seal includes a protrusion (42) formed on one of the container body about the opening or the cap, and a groove (44) formed on the other of the container body about the opening or the cap. The protrusion is received by the groove when the assembly is in the closed position, such that contact is maintained in a sealing relationship around the opening between the groove and the protrusion.

Abstract: A cap and container assembly includes a container having a base and a side wall extending upward from the base. The base and the side wall define an interior, and the side wall defines an opening leading to the interior. A cap moves with respect to the container between an opened position in which the opening is exposed, and a closed position in which the cap covers the opening. A tab projects outward from the cap and has a bottom surface. A spacer projects from the container side wall at a location beneath the tab when the assembly is in the closed position. The spacer bends inward towards the container in response to application of a sufficient force, to move from a locked position that blocks the bottom surface of the tab, to an unlocked position to expose at least a portion of the bottom surface of the tab.

Abstract: A packaging assembly includes a container body defining an interior for housing a product and an opening leading to the interior. The assembly further includes a cap that moves with respect to the container body to move the assembly between a closed position in which the cap covers the opening, and an opened position in which the opening is exposed. A first seal (40) is defined between the container body and the cap. The first seal includes a protrusion (42) formed on one of the container body about the opening or the cap, and a groove (44) formed on the other of the container body about the opening or the cap. The protrusion is received by the groove when the assembly is in the closed position, such that contact is maintained in a sealing relationship around the opening between the groove and the protrusion.

Abstract: A packaging assembly includes a container body defining an interior for housing a product and an opening leading to the interior. The assembly further includes a cap that moves with respect to the container body to move the assembly between a closed position in which the cap covers the opening, and an opened position in which the opening is exposed. A first seal (40) is defined between the container body and the cap. The first seal includes a protrusion (42) formed on one of the container body about the opening or the cap, and a groove (44) formed on the other of the container body about the opening or the cap. The protrusion is received by the groove when the assembly is in the closed position, such that contact is maintained in a sealing relationship around the opening between the groove and the protrusion.

Abstract: A pharmaceutical package comprises a polymeric wall having an interior surface and an outer surface; and a tie coating of SiOxCy and/or a barrier coating of SiOx and/or a protective coating of SiOxCy on the interior surface. The walls may be formed into the vessel by means of laser welding. The package can be, for example, a rigid container, a bioprocessing bag or a transfer bag, wherein the coatings afford improved barrier properties and/or are effective to block extractables/leachables from the substrate and any coatings thereon and the coatings are able to maintain their desirable characteristics described herein against stretching/elongation conditions. The bag or rigid container can be used in the entire process of the CAR T cell manufacture/therapy. A method of handling the coated packages comprises limiting stretching the packages. The method of monitoring or controlling the internal pressure of the coated packages is also described.

Abstract: A moisture-tight, re-sealable container is disclosed having a lid and body. The lid and body have a non-round seal that is substantially moisture tight when the lid is seated on the body, admitting less than 1000 micrograms per day of water to a package. A reinforcement stiffens or reinforces at least a portion of the seal against inward deflection along an axis defined by the minor diameter when the lid is seated on the body. Optionally the reinforcement is at least one spline subdividing the reservoir. A method of making dispensers for objects of varying length to customize particular dispensers to dispense such objects of a particular length is also disclosed.

Abstract: A cap and container assembly includes a container having a base and a side wall extending upward from the base. The base and the side wall define an interior, and the side wall defines an opening leading to the interior. A cap moves with respect to the container between an opened position in which the opening is exposed, and a closed position in which the cap covers the opening. A tab projects outward from the cap and has a bottom surface. A spacer projects from the container side wall at a location beneath the tab when the assembly is in the closed position. The spacer bends inward towards the container in response to application of a sufficient force, to move from a locked position that blocks the bottom surface of the tab, to an unlocked position to expose at least a portion of the bottom surface of the tab.

Abstract: A cap and container assembly includes a container having a base and a side wall extending upward from the base. The base and the side wall define an interior, and the side wall defines an opening leading to the interior. A cap moves with respect to the container between an opened position in which the opening is exposed, and a closed position in which the cap covers the opening. A tab projects outward from the cap and has a bottom surface. A spacer projects from the container side wall at a location beneath the tab when the assembly is in the closed position. The spacer bends inward towards the container in response to application of a sufficient force, to move from a locked position that blocks the bottom surface of the tab, to an unlocked position to expose at least a portion of the bottom surface of the tab.

Abstract: A packaging assembly includes a container body defining an interior for housing a product and an opening leading to the interior. The assembly further includes a cap that moves with respect to the container body to move the assembly between a closed position in which the cap covers the opening, and an opened position in which the opening is exposed. A first seal (40) is defined between the container body and the cap. The first seal includes a protrusion (42) formed on one of the container body about the opening or the cap, and a groove (44) formed on the other of the container body about the opening or the cap. The protrusion is received by the groove when the assembly is in the closed position, such that contact is maintained in a sealing relationship around the opening between the groove and the protrusion.

Abstract: A moisture-tight, re-sealable container is disclosed having a lid and body. The lid and body have a non-round seal that is substantially moisture tight when the lid is seated on the body, admitting less than 1000 micrograms per day of water to a package. A reinforcement stiffens or reinforces at least a portion of the seal against inward deflection along an axis defined by the minor diameter when the lid is seated on the body. Optionally the reinforcement is at least one spline subdividing the reservoir. A method of making dispensers for objects of varying length to customize particular dispensers to dispense such objects of a particular length is also disclosed.

Abstract: A firetube scraper device comprising: at least one carriage assembly mounted on the firetube; a drive line and drive means for displacing the carriage assembly longitudinally along the firetube; wherein said carriage assembly surrounding the entire circumference of the firetube and comprising at least one row of scraper fins, each of said scraper fins having an inner surface adapted to frictionally engage an outer firetube surface defined by at least an upper portion of the surface of the firetube exposed to contaminants deposited onto a firetube surface.

Abstract: A moisture-tight, re-sealable container is disclosed having a lid and body. The lid and body have a non-round seal that is substantially moisture tight when the lid is seated on the body, admitting less than 1000 micrograms per day of water to a package. A reinforcement stiffens or reinforces at least a portion of the seal against inward deflection along an axis defined by the minor diameter when the lid is seated on the body. Optionally the reinforcement is at least one spline subdividing the reservoir. A method of making dispensers for objects of varying length to customize particular dispensers to dispense such objects of a particular length is also disclosed.

Abstract: A cap and container assembly includes a container having a base and a side wall extending upward from the base. The base and the side wall define an interior, and the side wall defines an opening leading to the interior. A cap moves with respect to the container between an opened position in which the opening is exposed, and a closed position in which the cap covers the opening. A tab projects outward from the cap and has a bottom surface. A spacer projects from the container side wall at a location beneath the tab when the assembly is in the closed position. The spacer bends inward towards the container in response to application of a sufficient force, to move from a locked position that blocks the bottom surface of the tab, to an unlocked position to expose at least a portion of the bottom surface of the tab.

Abstract: A cap and container assembly includes a container having a base and a side wall extending upward from the base. The base and the side wall define an interior, and the side wall defines an opening leading to the interior. A cap moves with respect to the container between an opened position in which the opening is exposed, and a closed position in which the cap covers the opening. A tab projects outward from the cap and has a bottom surface. A spacer projects from the container side wall at a location beneath the tab when the assembly is in the closed position. The spacer bends inward towards the container in response to application of a sufficient force, to move from a locked position that blocks the bottom surface of the tab, to an unlocked position to expose at least a portion of the bottom surface of the tab.

Abstract: A firetube scraper device comprising: at least one carriage assembly mounted on the firetube; a drive line and drive means for displacing the carriage assembly longitudinally along the firetube; wherein said carriage assembly surrounding the entire circumference of the firetube and comprising at least one row of scraper fins, each of said scraper fins having an inner surface adapted to frictionally engage an outer firetube surface defined by at least an upper portion of the surface of the firetube exposed to contaminants deposited onto a firetube surface.

Abstract: A cap and container assembly includes a container having a base and a side wall extending upward from the base. The base and the side wall define an interior, and the side wall defines an opening leading to the interior. A cap moves with respect to the container between an opened position in which the opening is exposed, and a closed position in which the cap covers the opening. A tab projects outward from the cap and has a bottom surface. A spacer projects from the container side wall at a location beneath the tab when the assembly is in the closed position. The spacer bends inward towards the container in response to application of a sufficient force, to move from a locked position that blocks the bottom surface of the tab, to an unlocked position to expose at least a portion of the bottom surface of the tab.