Abstract: In alternative embodiments, provided are methods for treating and ameliorating a cancer, or recurrence of a cancer such as acute myeloid leukemia (AML) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 (or rebecsinib) and second drug such as an ATP-competitive protein tyrosine kinase inhibitor such as dasatinib. In alternative embodiments, provided are methods for the in vivo inhibition of myeloproliferative neoplasm (MPN) or AML stem cell propagation comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. In alternative embodiments, provided are methods for the in vivo inhibition pre-leukemia stem cell (pre-LSC) transformation into leukemia stem cells (LSCs) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug.

Abstract: A sensor system, particularly for monitoring the mixing of at least two fluids and a method for monitoring the mixture of at least two liquids. The present invention provides a sensor system for fluids, comprising at least two level sensor which are arranged vertically one upon the other on and connected to an electronic circuit board, four electrodes of four conductivity sensors which are arranged horizontally next to each other at the bottom of and connected to the electronic circuit board; and a temperature sensor which is connected to the electronic circuit board; a connector for connecting the electronic circuit board to a controller; wherein the electronic circuit board is embedded in a hot melt compound which is surrounded by an injection molded housing.

Abstract: Disclosed herein are bio-based polymers, methods to prepare the same, bio-based polymer products, methods to degrade the same, and methods to recycle the same.

Abstract: A sensor system, particularly for monitoring the mixing of at least two fluids and a method for monitoring the mixture of at least two liquids. The present invention provides a sensor system for fluids, comprising at least two level sensor which are arranged vertically one upon the other on and connected to an electronic circuit board, four electrodes of four conductivity sensors which are arranged horizontally next to each other at the bottom of and connected to the electronic circuit board; and a temperature sensor which is connected to the electronic circuit board; a connector for connecting the electronic circuit board to a controller; wherein the electronic circuit board is embedded in a hot melt compound which is surrounded by an injection molded housing.

Abstract: The disclosure relates to the biosynthesis of cannabinoids and related prenylated phenolic compounds using recombinant enzymes. In particular, the disclosure provides recombinant prenyltransferase enzymes engineered to produce a greater amount of a desired product, or to have a greater ability to catalyze a reaction using a desired substrate, as compared to the wild type prenyltransferase. The disclosure also provides methods of preparing such recombinant enzymes; as well as methods of use thereof in improving the biosynthesis of cannabinoids and related prenylated phenolic compounds.

Abstract: A sensor for determining the oscillating frequency in a fluidic oscillating nozzle and provides an oscillating nozzle, comprising a fluidic oscillator with inlet and outlet and a main channel and at least one control passage surrounding the main channel, and a splitter comprising at least two splitter channels which is attached to the outlet of the fluidic oscillator, wherein the sleeve of at least one of the at least two splitter channels comprises partially a flexible foil. The invention also relates to a method for monitoring a dispensed fluid jet, comprising the steps of providing an oscillating nozzle as described above; and injecting a fluid jet and in parallel determining the oscillation frequency by determining the deformation changes of the flexible foil.

Abstract: The disclosure relates to the biosynthesis of cannabinoids and related prenylated phenolic compounds using recombinant enzymes. In particular, the disclosure provides recombinant mutant ORF2 enzymes engineered to produce a greater amount of a desired product, or to have a greater ability to catalyze a reaction using a desired substrate, as compared to WT ORF2. The disclosure also provides methods of preparing such ORF2 mutant enzymes; as well as methods of use thereof in improving the biosynthesis of cannabinoids and related prenylated phenolic compounds.

Abstract: A scanning method with simple mechanics for use in an automated analyser to scan objects or codes on objects. The invention enables one to move a scanning unit comprising a camera and two deflection mirrors and to set two different focus levels with one and the same drive unit.

Abstract: A scanning method with simple mechanics for use in an automated analyser to scan objects or codes on objects. The invention enables one to move a scanning unit comprising a camera and two deflection mirrors and to set two different focus levels with one and the same drive unit.

Abstract: The disclosure relates to the biosynthesis of cannabinoids and related prenylated phenolic compounds using recombinant enzymes. In particular, the disclosure provides recombinant mutant ORF2 enzymes engineered to produce a greater amount of a desired product, or to have a greater ability to catalyze a reaction using a desired substrate, as compared to WT ORF2. The disclosure also provides methods of preparing such ORF2 mutant enzymes; as well as methods of use thereof in improving the biosynthesis of cannabinoids and related prenylated phenolic compounds.

Abstract: The disclosure relates to the biosynthesis of cannabinoids and related prenylated phenolic compounds using recombinant enzymes. In particular, the disclosure provides recombinant mutant ORF2 enzymes engineered to produce a greater amount of a desired product, or to have a greater ability to catalyze a reaction using a desired substrate, as compared to WT ORF2. The disclosure also provides methods of preparing such ORF2 mutant enzymes; as well as methods of use thereof in improving the biosynthesis of cannabinoids and related prenylated phenolic compounds.

Abstract: A connection device for providing both a connection for liquid transport and a connection for the transport of electrical energy is disclosed. The connection device comprises a first part and a second part, which detachably connect to one another such that a first liquid conduit comprised in the first part connects with a second liquid conduit comprised in the second part, and a primary coil comprised in the first part inductively couples to a secondary coil comprised in the second part, wherein the first part further comprises a first electronic circuit electrically connected to the primary coil, and the second part further comprises a second electronic circuit electrically connected to the secondary coil.

Abstract: A scanning method with simple mechanics for use in an automated analyser to scan objects or codes on objects. The invention enables one to move a scanning unit comprising a camera and two deflection mirrors and to set two different focus levels with one and the same drive unit.

Abstract: A disposable dispenser unit is disclosed. The disposable dispenser unit comprises a fluid reservoir, a tag for storing information, a dispenser head having a pump chamber and at least one injector nozzle, and a means disposed at the dispenser head for attachment thereof to a diagnostic system, wherein the pump chamber comprises a piston and the piston comprises a volume which can be filled with fluid.

Abstract: A fan arrangement (1), in particular for cooling an engine system, comprising: an impeller (10) having one or more blades (4) which in operation convey a medium in the direction of an axis of rotation of the impeller (10) from an inlet side (E) to an outlet side (A); a housing shroud (6) having a base part (61) which extends in the direction of the axis of rotation and surrounds the impeller (10) completely or partially, wherein, on an end of the base part (61) oriented towards the outlet side (A) of the impeller (10), there is provided a discharge flow element (63) which extends radially outwards from the end of the base part (61).

Abstract: A disposable dispenser unit is disclosed. The disposable dispenser unit comprises a fluid reservoir, a tag for storing information, a dispenser head having a pump chamber and at least one injector nozzle, and a means disposed at the dispenser head for attachment thereof to a diagnostic system, wherein the pump chamber comprises a piston and the piston comprises a volume which can be filled with fluid.

Abstract: A connection device for providing both a connection for liquid transport and a connection for the transport of electrical energy is disclosed. The connection device comprises a first part and a second part, which detachably connect to one another such that a first liquid conduit comprised in the first part connects with a second liquid conduit comprised in the second part, and a primary coil comprised in the first part inductively couples to a secondary coil comprised in the second part, wherein the first part further comprises a first electronic circuit electrically connected to the primary coil, and the second part further comprises a second electronic circuit electrically connected to the secondary coil.

Abstract: A system and method for storing and retrieving a sparse matrix from memory of a computing device while minimizing the amount of data stored and costly jumps in memory. The computing device may be an FPGA having memory and processing elements. The method comprises storing non-zero data elements of the matrix in a data array and storing their corresponding column address values in a column index array. To read this stored data from memory, each preceding value of the column index array may be compared with each current value of the column index array to determine if the data array value corresponding with the current column index array value belongs on the next row of the matrix. The method may include pre-ordering the matrix with zero-pad placeholders or creating a row increment pointer array which typically stores fewer values than the number of rows in the matrix.

Abstract: A device and a method are used for measuring the filling level of a fluid for monitoring a dispense/aspirate process in reaction vessels, including at least one cavity for dispensing and aspirating the fluid, where the cavity is provided with a filling level sensor whose signals, transmitted to an evaluation unit, are evaluated to determine the filling level, the at least one cavity is assigned a receiving body which is closed at the bottom and is separated from the cavity for receiving the fluid, the filling level sensor is at least one thermistor extending along the outside of a wall of the receiving body without coming in contact with the fluid, the evaluation unit evaluates the temperature influence of the thermistor in dispensing, aspirating and in retention of the fluid in the receiving body to detect the filling level, in this way the process monitoring in washing the reaction vessels is improved.

Abstract: A system and method for storing and retrieving a sparse matrix from memory of a computing device while minimizing the amount of data stored and costly jumps in memory. The computing device may be an FPGA having memory and processing elements. The method comprises storing non-zero data elements of the matrix in a data array and storing their corresponding column address values in a column index array. To read this stored data from memory, each preceding value of the column index array may be compared with each current value of the column index array to determine if the data array value corresponding with the current column index array value belongs on the next row of the matrix. The method may include pre-ordering the matrix with zero-pad placeholders or creating a row increment pointer array which typically stores fewer values than the number of rows in the matrix.