Abstract: The present inventions, in one aspect, are directed to a wound cover to, in operation, be disposed on or over a wound of a user and temporarily affixed to a wound site, having the wound therein, of the user, the wound cover comprising a wound cover stack having a plurality of layers formed in an integrated, unitary structure including a mesh pad layer, a sensor layer, disposed on the mesh pad layer, the sensor layer having a plurality of physiological sensors, configured to detect physiological characteristics and, in response, generate physiological data which are representative thereof, a communication layer configured to output (wired or wirelessly) the data measured or detected by the physiological sensors to circuitry external to the wound cover, and an outer/adhesive layer to, in operation, temporarily affix the wound cover to the wound site of the user.

Abstract: The invention is directed to a method of treating a patient with DRH and/or HFpEf including the steps of: treating the patient with angiotensin converting enzyme inhibitor (ACEI) and/or an angiotensin receptor blocking [ARB] drug; and cardiac pacing the patient as controlled by a BaroPace algorithm. Performance is improved by simultaneously withholding administration of any beta-1 selective beta adrenergic blockers. A method of cardiac pacing to treat drug resistant hypertension and heart failure with preserved ejection fraction (HFpEF) includes the steps of administering to a patient a therapeutic amount of a beta blocker having intrinsic sympathomimetic activity (ISA); and pacing the heart of a patient using the BaroPace algorithm.

Abstract: The invention is a method of using thoracic electrical bioimpedance (TEB) as a component in a real-time closed-loop system to treat drug resistant hypertension (DRH) or diastolic heart failure (called HFpEF in patients with pacemakers using machine learning/AI and an algorithm (PressurePace—see the incorporated specifications) utilizing a “micro-interval” or continually updated trending method with the pacemaker's hardware/software as the source of the bioimpedance measurement, e.g. OptiVol. An apparatus for performing the method, and software instructions stored on a tangible medium for controlling a computer or processor to perform the method are included.

Abstract: A method of right atrial pacing of a heart of a patient includes the steps of: stimulating right atrial tissue of the heart using a right atrial lead of a dual chamber cardiac pacemaker to pace the heart with a stimulus architecture protocol; and stimulating local sympathetic and/or parasympathetic tissues with the stimulus architecture protocol proximate to the paced right atrial tissue causing nervous system activity that inhibits the autonomous nervous system to reduce blood pressure. A closed loop system operating according to this method and a cardiac pacing lead for implementing this method also are included within the scope of the illustrated embodiments.

Abstract: The illustrated embodiments include an apparatus having a programmable, implantable pacemaker with a controllable pacing rate; and a blood pressure monitoring device having an output communicated to the pacemaker. The pacemaker selectively and automatically modulates pacing rate in response to monitored blood pressure to reduce hypertensive blood pressure in a patient or treatment for DCHF (HPpEF). The embodiments also include a. method tor operating a pacing device to treat drug resistant hypertension which includes the steps of monitoring blood pressure; and controlling rate modulation in the pacing device in response to the monitored blood pressure to selectively prevent excessive pacing to reduce mean arterial blood pressure fay either inhibiting rate modulation in the pacing device or by changing rate modulation parameters.

Abstract: A pacemaker control system includes a pacemaker; a plurality of sensors which are internal to the pacemaker, a plurality of sensors which are external to the pacemaker, a circuit for entering patient reports; and a circuit for using artificial intelligence to process outputs from the plurality sensors internal and external to the pacemaker and from the circuit for entering patient reports, which are collectively identified as a labeled dataset, to reiteratsvely learn a function which determines the labeled dataset most likely to provide optimal pacemaker function for the patient. The means for using artificial intelligence comprises a database of archive outputs from the plurality sensors internal and external to the pacemaker and from the means for entering patient reports for the patient used for optimization of rate modulation to intelligently, continuously and physiologically control the pacemaker.

Abstract: The invention discloses a system, method and medical device for measuring various hemoglobin derivatives, such as oxyhemoglobin, reduced hemoglobin, partial hemoglobin, carboxyhemoglobin, methemoglobin and sulfhemoglobin in whole or in hemolyzed blood. The novel method uses a statistical approach to enable the design of a portable co-oximeter. This portable co-oximeter utilizes compact light sources, such as light emitting diodes or light emitting lasers, to emit light in the visible region. Being portable, the device is a point-of-care device that can be used in emergency situations by paramedics, in the emergency room, and in a physicians office to detect and measure the concentrations and/or percentages of functional and non-functional hemoglobin derivatives in a patient's blood.