Patents by Inventor Michael C. Bassik

Michael C. Bassik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENHANCEMENT OF ANTI-TUMOR PHAGOCYTOSIS
    Publication number: 20240052028
    Abstract: The present disclosure provides methods for treating a disease or disorder or sensitizing a cell to phagocytosis. The methods comprise contacting a cell with an inhibitor of Adipocyte Plasma Membrane Associated Protein (APMAP), an agonist of fatty-acid G-protein coupled receptor GPR84, or a combination thereof. The methods may further comprise contacting the cell with at least one or both of a tumor antigen (TA)-targeting antibody and a CD47 blocking antibody. The present disclosure also provides methods for determining cellular regulators of phagocytosis.
    Type: Application
    Filed: October 5, 2021
    Publication date: February 15, 2024
    Inventors: Michael C. Bassik, Roarke Kamber
  • Compositions and methods for treating age-related diseases
    Patent number: 11891442
    Abstract: Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: February 6, 2024
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, John Vincent Pluvinage, Michael C. Bassik, Michael Haney, Benjamin Smith, Carolyn Bertozzi
  • COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DISEASES
    Publication number: 20200317778
    Abstract: Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.
    Type: Application
    Filed: December 21, 2018
    Publication date: October 8, 2020
    Inventors: Anton Wyss-Coray, John Vincent Pluvinage, Michael C. Bassik, Michael Haney, Benjamin Smith, Carolyn Bertozzi
  • Use of a DHODH inhibitor in combination with an inhibitor of pyrimidine salvage
    Patent number: 10736911
    Abstract: Compounds and methods are provided for the treatment of pathogenic virus infections or cancer. The formulations combine an inhibitor of de novo pyrimidine synthesis, and an inhibitor of a pyrimidine salvage pathway enzyme.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: August 11, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard Deans, Ayse Okesli, David Morgens, Chaitan Khosla, Michael C. Bassik
  • TARGETED MUTAGENESIS
    Publication number: 20190309288
    Abstract: Provided herein is technology relating to the mutagenesis of nucleic acids, e.g., for directed evolution, and particularly, but not exclusively, to methods, compositions, and kits for producing nucleic acids and/or proteins comprising mutations and substitutions within specific target sequences.
    Type: Application
    Filed: August 18, 2017
    Publication date: October 10, 2019
    Inventors: Gaelen Hess, Michael C. Bassik
  • USE OF A DHODH INHIBITOR IN COMBINATION WITH AN INHIBITOR OF PYRIMIDINE SALVAGE
    Publication number: 20190209598
    Abstract: Compounds and methods are provided for the treatment of pathogenic virus infections or cancer. The formulations combine an inhibitor of de novo pyrimidine synthesis, and an inhibitor of a pyrimidine salvage pathway enzyme.
    Type: Application
    Filed: December 22, 2016
    Publication date: July 11, 2019
    Inventors: Richard Deans, Ayse Okesli, David Morgens, Chaitan Khosla, Michael C. Bassik