Abstract: Described herein are methods and compositions for treating tumors harboring gene fusions. In some embodiments, the present disclosure provides a method of treating tumors harboring gene fusions comprising administering to a subject in need thereof a Raf kinase inhibitor or a pharmaceutically acceptable salt thereof. In some embodiments, the Raf kinase inhibitor or a pharmaceutically acceptable salt thereof is (R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl) thiazole-5-carboxamide. In some embodiments, the gene fusion is a CRAF gene fusion, a BRAF gene fusion, or both.

Abstract: A computer-implemented method for automatically adjusting a moldboard of a motor grader can include receiving one or more identifiers corresponding to a configuration of the motor grader, and determining, based on the received identifier(s), a first orientation of the moldboard. If the first orientation is not within an operating threshold, the method can further include selecting, based on the one or more identifiers, at least one of a plurality of actuators of the motor grader; and actuating the selected actuator(s) to move the moldboard from the first orientation to a second orientation within the operating threshold.

Abstract: An electric grinding tool includes a motor housing coupleable to an electrical power source, a motor configured to receive power from the electrical power source and including an output shaft extending along a motor axis, a handgrip coupled to and coaxial with the motor housing, a tool holder rotatably driven upon rotation of the motor, the tool holder configured to receive a shaft of a grinding accessory, and a light unit coupled to and at least partially recessed in a front end portion of the electric grinding tool. The light unit includes a plurality of lights mounted to an at least partially ring shaped printed circuit board that is received in a support ring, and a cover ring received over the lights.

Abstract: A business application may provide a secure ledger update while maintaining anonymity and security from unauthorized third parties. One example may include receiving a new entry transaction to save data in a database/ledger. The example may also include receiving a request to add a record stored in a database with a new entry, adding the record by inserting the new entry, and enabling the new entry to be unchangeable from subsequent modification attempts based on an immutable attribute.

Abstract: A business application may provide a secure ledger update while maintaining anonymity and security from unauthorized third parties. One example may include receiving a new entry transaction to save data in a database/ledger. The example may also include receiving a request to add a record stored in a database with a new entry, adding the record by inserting the new entry, and enabling the new entry to be unchangeable from subsequent modification attempts based on an immutable attribute.

Abstract: A business application may provide a secure ledger update while maintaining anonymity and security from unauthorized third parties. One example may include receiving a new entry transaction to save data in a database/ledger. The example may also include receiving a request to add a record stored in a database with a new entry, adding the record by inserting the new entry, and enabling the new entry to be unchangeable from subsequent modification attempts based on an immutable attribute.

Abstract: A business application may provide a secure ledger update while maintaining anonymity and security from unauthorized third parties. One example may include receiving a new entry transaction to save data in a database/ledger. The example may also include receiving a request to add a record stored in a database with a new entry, adding the record by inserting the new entry, and enabling the new entry to be unchangeable from subsequent modification attempts based on an immutable attribute.

Abstract: In one embodiment, the invention provides a method of configuring a migration from a plurality of distributed virtual servers to a system of blades, the method comprising: identifying among the plurality of distributed virtual servers a plurality of candidate virtual servers for inclusion in the migration; collecting performance data for each candidate virtual server; consolidating the performance data for each candidate virtual server into a usage profile; normalizing the usage profile to allow representation of a statistical measure of resource usage by the candidate virtual server; and constructing a configuration for the plurality of candidate virtual servers within the system of blades.

Abstract: In one embodiment, the invention provides a method of configuring a migration from a plurality of distributed virtual servers to a system of blades, the method comprising: identifying among the plurality of distributed virtual servers a plurality of candidate virtual servers for inclusion in the migration; collecting performance data for each candidate virtual server; consolidating the performance data for each candidate virtual server into a usage profile; normalizing the usage profile to allow representation of a statistical measure of resource usage by the candidate virtual server; and constructing a configuration for the plurality of candidate virtual servers within the system of blades.

Abstract: A computer system, including at least one host (processor and operating system), a channel subsystem and at least one switch (together with an associated switch controller) for switchably connecting an I/O device (together with an associated I/O device control unit) to a host via said channel subsystem, in combination with means for dynamically managing I/O connectivity in said computer from each host. The I/O manager's functions are centralized at the host level across the computer system. Each host is responsible for an instance of the manager.