Abstract: Described herein are methods and compositions for treating tumors harboring gene fusions. In some embodiments, the present disclosure provides a method of treating tumors harboring gene fusions comprising administering to a subject in need thereof a Raf kinase inhibitor or a pharmaceutically acceptable salt thereof. In some embodiments, the Raf kinase inhibitor or a pharmaceutically acceptable salt thereof is (R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl) thiazole-5-carboxamide. In some embodiments, the gene fusion is a CRAF gene fusion, a BRAF gene fusion, or both.

Abstract: A business application may provide a secure ledger update while maintaining anonymity and security from unauthorized third parties. One example may include receiving a new entry transaction to save data in a database/ledger. The example may also include receiving a request to add a record stored in a database with a new entry, adding the record by inserting the new entry, and enabling the new entry to be unchangeable from subsequent modification attempts based on an immutable attribute.

Abstract: A business application may provide a secure ledger update while maintaining anonymity and security from unauthorized third parties. One example may include receiving a new entry transaction to save data in a database/ledger. The example may also include receiving a request to add a record stored in a database with a new entry, adding the record by inserting the new entry, and enabling the new entry to be unchangeable from subsequent modification attempts based on an immutable attribute.

Abstract: A business application may provide a secure ledger update while maintaining anonymity and security from unauthorized third parties. One example may include receiving a new entry transaction to save data in a database/ledger. The example may also include receiving a request to add a record stored in a database with a new entry, adding the record by inserting the new entry, and enabling the new entry to be unchangeable from subsequent modification attempts based on an immutable attribute.

Abstract: A business application may provide a secure ledger update while maintaining anonymity and security from unauthorized third parties. One example may include receiving a new entry transaction to save data in a database/ledger. The example may also include receiving a request to add a record stored in a database with a new entry, adding the record by inserting the new entry, and enabling the new entry to be unchangeable from subsequent modification attempts based on an immutable attribute.

Abstract: In one embodiment, the invention provides a method of configuring a migration from a plurality of distributed virtual servers to a system of blades, the method comprising: identifying among the plurality of distributed virtual servers a plurality of candidate virtual servers for inclusion in the migration; collecting performance data for each candidate virtual server; consolidating the performance data for each candidate virtual server into a usage profile; normalizing the usage profile to allow representation of a statistical measure of resource usage by the candidate virtual server; and constructing a configuration for the plurality of candidate virtual servers within the system of blades.

Abstract: In one embodiment, the invention provides a method of configuring a migration from a plurality of distributed virtual servers to a system of blades, the method comprising: identifying among the plurality of distributed virtual servers a plurality of candidate virtual servers for inclusion in the migration; collecting performance data for each candidate virtual server; consolidating the performance data for each candidate virtual server into a usage profile; normalizing the usage profile to allow representation of a statistical measure of resource usage by the candidate virtual server; and constructing a configuration for the plurality of candidate virtual servers within the system of blades.

Abstract: A computer system, including at least one host (processor and operating system), a channel subsystem and at least one switch (together with an associated switch controller) for switchably connecting an I/O device (together with an associated I/O device control unit) to a host via said channel subsystem, in combination with means for dynamically managing I/O connectivity in said computer from each host. The I/O manager's functions are centralized at the host level across the computer system. Each host is responsible for an instance of the manager.