Patents by Inventor Michael C. Gagne
Michael C. Gagne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12253189Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.Type: GrantFiled: March 9, 2022Date of Patent: March 18, 2025Assignee: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates
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Publication number: 20250064677Abstract: A single-use fluid container includes a flexible bag having a bottom surface and one or more side surfaces. A port or aperture is formed in the bottom surface of the flexible bag that serves as an inlet port to a multi-outlet pump that is fluidically coupled to the flexible bag. The flexible bag includes one or more return ports disposed in one or more side surfaces and/or bottom surface of the flexible bag, the one or more return ports having a valve therein. One or more of the outlets of the pump are connected to conduit or tubing that also connect to one or more of the return ports. Fluid contained in the flexible bag can then be recirculated back into the flexible bag for mixing and/or agitation. Optional sparger ports may be provided for the addition of a sparging gas.Type: ApplicationFiled: November 11, 2024Publication date: February 27, 2025Applicant: AQUASYN, LLCInventor: Michael C. Gagne
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Patent number: 12181076Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.Type: GrantFiled: May 3, 2021Date of Patent: December 31, 2024Assignee: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates
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Publication number: 20240342055Abstract: A method of pumping fluid out of a bioprocess vessel includes providing a bioprocess vessel defining an interior volume and having a bottom surface containing an aperture or port therein for the passage of fluid and a pump head integrally formed with or bonded to the bottom surface of the bioprocess vessel or secured to the port, wherein the pump head further comprises an inlet and an outlet with the inlet in fluid communication with the interior volume, the pump head further including a plurality of diaphragms, each diaphragm associated with a check-valve, wherein sequential actuation of the plurality of diaphragms pumps fluid from the interior volume of the bioprocess vessel into the inlet and out of the outlet. The plurality of diaphragms are actuated with a motor secured to the pump head. In other embodiments, the pump head is secured to the bioprocess vessel with fasteners.Type: ApplicationFiled: June 25, 2024Publication date: October 17, 2024Applicant: ALPHINITY USA, INC.Inventor: Michael C. Gagne
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Patent number: 12048671Abstract: A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.Type: GrantFiled: April 19, 2023Date of Patent: July 30, 2024Assignee: ALPHINITY USA, INC.Inventor: Michael C. Gagne
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Publication number: 20240239647Abstract: A bioprocess or pharmaceutical vessel which may include a flexible bag or substantially rigid container defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the vessel. The pump has an inlet that is in fluidic communication with the interior of the vessel and a plurality of outlets, whereby fluid passes from the interior volume of the vessel and into the inlet of the pump and out the plurality of outlets. The vessel may also include one or more return lines that return fluid to the interior volume of the vessel. When fluid is pumped through the return lines, the return lines undulate, flail about, or otherwise move to impart agitation and/or mixing of the fluid contained in the vessel.Type: ApplicationFiled: June 2, 2022Publication date: July 18, 2024Applicant: ALPHINITY USA, INC.Inventor: Michael C. Gagne
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Publication number: 20240133472Abstract: A valve assembly with a multidirectional flow path includes a valve body that includes respective hinged portions defining respective passageways extending through the valve body when in a closed state. A flexible conduit or tubing having a loop portion and a plurality of branches extending from the loop portion is at least partially positioned within the valve body. Portions of the loop that extend beyond the valve body are encapsulated by respective rigid jackets. Multiple valves are situated on the valve body and are used to selectively pinch the loop portion in different pinching configurations to direct fluid to or from the particular branches. The valve assembly may be integrated into a manufacturing or other production process with optional additional jackets used to encapsulate the flexible conduit branches.Type: ApplicationFiled: January 5, 2024Publication date: April 25, 2024Applicant: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates, Dean C. Richards, Scott Bendon
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Patent number: 11898645Abstract: A valve assembly with a multidirectional flow path includes a valve body that includes respective hinged portions defining respective passageways extending through the valve body when in a closed state. A flexible conduit or tubing having a loop portion and a plurality of branches extending from the loop portion is at least partially positioned within the valve body. Portions of the loop that extend beyond the valve body are encapsulated by respective rigid jackets. Multiple valves are situated on the valve body and are used to selectively pinch the loop portion in different pinching configurations to direct fluid to or from the particular branches. The valve assembly may be integrated into a manufacturing or other production process with optional additional jackets used to encapsulate the flexible conduit branches.Type: GrantFiled: July 15, 2020Date of Patent: February 13, 2024Assignee: REPLIGEN CORPORATIONInventors: Michael C. Gagne, Steven V. Cates, Dean C. Richards, Scott Bendon
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Publication number: 20240033179Abstract: A system for the preparation of fluids for bioprocess and pharmaceutical applications uses one or more flexible bags that are pre-loaded with solid tablets contained therein of various buffer/media/physiological fluid constituents. Examples include salts, acids, bases, preservatives, proteins, amino acids, growth factors, small molecules, and drugs. The flexible bag contains one or more sealed or sealable openings that are used to add water to the interior of the flexible bag as well as remove fluid from the flexible bag. The one or more sealed openings may also be used as an outlet to remove fluid (e.g., buffer) from the flexible bag. The flexible bag may be stored in a deflated state aiding in the storage and/or transport of the flexible bag. Multiple flexible bags may be coupled to a manifold with valves to selectively fill and empty the flexible bags.Type: ApplicationFiled: September 21, 2021Publication date: February 1, 2024Applicant: ALPHINITY USA, INC.Inventor: Michael C. Gagne
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Publication number: 20230358223Abstract: A pump or combination pump/mixer device is disclosed. The pump or pump/mixer uses moving diaphragms in combination with check valves to pump and/or mix fluid. A main inlet is located at the top of the pump and is fed by a vessel or container that contains fluid. The fluid, in response to the moving diaphragms, passes through an outer chamber into a plurality of lower chambers and then into a central chamber where the fluid then exits via one or more outlets. A series of check-valves are used to ensure one-way flow of fluid through the chambers. The drive shaft of a motor or drive unit drives a nutating disk or wobble plate that actuates the diaphragms to drive fluid through the device. In the pump/mixer configuration, one or more additional inlets are provided to input additional fluids into the device for mixing within the inside of the pump/mixer.Type: ApplicationFiled: January 29, 2021Publication date: November 9, 2023Applicant: ALPHINITY USA, INC.Inventor: Michael C. Gagne
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Publication number: 20230358321Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.Type: ApplicationFiled: July 12, 2023Publication date: November 9, 2023Applicant: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates
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Publication number: 20230293388Abstract: A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.Type: ApplicationFiled: April 19, 2023Publication date: September 21, 2023Applicant: ALPHINITY USA, INC.Inventor: Michael C. Gagne
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Patent number: 11754191Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.Type: GrantFiled: June 8, 2022Date of Patent: September 12, 2023Assignee: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates
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Patent number: 11719348Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.Type: GrantFiled: July 20, 2022Date of Patent: August 8, 2023Assignee: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates
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Patent number: 11666508Abstract: A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.Type: GrantFiled: April 13, 2022Date of Patent: June 6, 2023Assignee: ALPHINITY USA, INC.Inventor: Michael C. Gagne
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Patent number: 11578809Abstract: A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks. The conduit tracks can be connected to each other or other process components.Type: GrantFiled: August 17, 2021Date of Patent: February 14, 2023Assignee: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates, Scott Bendon
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Patent number: 11530772Abstract: A fluid plug for use with sterile processes such as the manufacture or production of pharmaceuticals and biologics is disclosed. The fluid plug is made of a material or materials that will tolerate sterilizing processes such as gamma irradiation. The fluid plug is used to selectively plug the ends of flexible polymer conduits that may be connected to fluids, reagents, or products used or generated as part of the manufacturing process. Also disclosed is the use of the plugs in combination with a series of valves in a block-and-bleed arrangement to enable the sterile transfer and connection of fluids, reagents, or products within a process flow.Type: GrantFiled: January 13, 2021Date of Patent: December 20, 2022Assignee: Repligen CorporationInventor: Michael C. Gagne
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Patent number: 11530752Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.Type: GrantFiled: July 20, 2022Date of Patent: December 20, 2022Assignee: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates
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Patent number: 11512987Abstract: A fluid monitoring assembly includes a conduit having a wall defining a lumen for carrying fluid. A sensor mount is integrally formed with the wall of the conduit and extends generally transverse with respect to a longitudinal axis of the conduit, the sensor mount including an aperture defining an inner surface extending to the lumen. The assembly includes a sensor configured to be removably secured within the sensor mount, the sensor having an elongate body terminating at one end thereof in a sensing portion, the elongate body having a male projection on a portion thereof and configured to rest within the inner surface of the sensor mount. The assembly further includes a housing having first and second portions connected to one another, the housing defining an interior portion configured to encapsulate the conduit, at least a portion of the elongate body of the sensor, and the sensor mount.Type: GrantFiled: April 13, 2021Date of Patent: November 29, 2022Assignee: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates, Dean C. Richards, Scott Bendon
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Publication number: 20220356955Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.Type: ApplicationFiled: July 20, 2022Publication date: November 10, 2022Applicant: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates