Patents by Inventor Michael C. Gagne
Michael C. Gagne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11578809Abstract: A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks. The conduit tracks can be connected to each other or other process components.Type: GrantFiled: August 17, 2021Date of Patent: February 14, 2023Assignee: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates, Scott Bendon
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Patent number: 11530772Abstract: A fluid plug for use with sterile processes such as the manufacture or production of pharmaceuticals and biologics is disclosed. The fluid plug is made of a material or materials that will tolerate sterilizing processes such as gamma irradiation. The fluid plug is used to selectively plug the ends of flexible polymer conduits that may be connected to fluids, reagents, or products used or generated as part of the manufacturing process. Also disclosed is the use of the plugs in combination with a series of valves in a block-and-bleed arrangement to enable the sterile transfer and connection of fluids, reagents, or products within a process flow.Type: GrantFiled: January 13, 2021Date of Patent: December 20, 2022Assignee: Repligen CorporationInventor: Michael C. Gagne
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Patent number: 11530752Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.Type: GrantFiled: July 20, 2022Date of Patent: December 20, 2022Assignee: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates
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Patent number: 11512987Abstract: A fluid monitoring assembly includes a conduit having a wall defining a lumen for carrying fluid. A sensor mount is integrally formed with the wall of the conduit and extends generally transverse with respect to a longitudinal axis of the conduit, the sensor mount including an aperture defining an inner surface extending to the lumen. The assembly includes a sensor configured to be removably secured within the sensor mount, the sensor having an elongate body terminating at one end thereof in a sensing portion, the elongate body having a male projection on a portion thereof and configured to rest within the inner surface of the sensor mount. The assembly further includes a housing having first and second portions connected to one another, the housing defining an interior portion configured to encapsulate the conduit, at least a portion of the elongate body of the sensor, and the sensor mount.Type: GrantFiled: April 13, 2021Date of Patent: November 29, 2022Assignee: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates, Dean C. Richards, Scott Bendon
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Publication number: 20220356955Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.Type: ApplicationFiled: July 20, 2022Publication date: November 10, 2022Applicant: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates
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Publication number: 20220356954Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.Type: ApplicationFiled: July 20, 2022Publication date: November 10, 2022Applicant: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates
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Publication number: 20220299121Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.Type: ApplicationFiled: June 8, 2022Publication date: September 22, 2022Inventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates
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Publication number: 20220233402Abstract: A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.Type: ApplicationFiled: April 13, 2022Publication date: July 28, 2022Applicant: ALPHINITY USA, INC.Inventor: Michael C. Gagne
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Patent number: 11384848Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.Type: GrantFiled: August 14, 2020Date of Patent: July 12, 2022Assignee: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates
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Publication number: 20220196162Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.Type: ApplicationFiled: March 9, 2022Publication date: June 23, 2022Applicant: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates
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Publication number: 20220163366Abstract: A method of using a fluid monitoring assembly for measuring the flow rate of a fluid through a flexible conduit comprising a wall that defines a lumen through which the fluid passes. The assembly includes a housing having first and second portions each defining respective recessed interior portions that define a cavity that is configured to encapsulate and retain the flow sensor and the flexible tubing contained therein. The flow sensor may be removably secured around the outside of the flexible conduit and include one or more transducer/receiver pairs.Type: ApplicationFiled: February 8, 2022Publication date: May 26, 2022Applicant: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates
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Patent number: 11331248Abstract: A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.Type: GrantFiled: January 29, 2018Date of Patent: May 17, 2022Assignee: ALPHINITY USA, INC.Inventor: Michael C. Gagne
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Patent number: 11274954Abstract: A method of using a fluid monitoring assembly for measuring the flow rate of a fluid through a flexible conduit comprising a wall that defines a lumen through which the fluid passes. The assembly includes a housing having first and second portions each defining respective recessed interior portions that define a cavity that is configured to encapsulate and retain the flow sensor and the flexible tubing contained therein. The flow sensor may be removably secured around the outside of the flexible conduit and include one or more transducer/receiver pairs.Type: GrantFiled: December 17, 2019Date of Patent: March 15, 2022Assignee: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates
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Patent number: 11231120Abstract: A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks. The conduit tracks can be connected to each other or other process components.Type: GrantFiled: February 18, 2020Date of Patent: January 25, 2022Assignee: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates, Scott Bendon
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Publication number: 20210372540Abstract: A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks. The conduit tracks can be connected to each other or other process components.Type: ApplicationFiled: August 17, 2021Publication date: December 2, 2021Applicant: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates, Scott Bendon
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Patent number: 11112021Abstract: A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks. The conduit tracks can be connected to each other or other process components.Type: GrantFiled: February 18, 2020Date of Patent: September 7, 2021Assignee: Repligen CorporationInventors: Michael C. Gagne, Dean C. Richards, Steven V. Cates, Scott Bendon
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Publication number: 20210254729Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.Type: ApplicationFiled: May 3, 2021Publication date: August 19, 2021Applicant: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates
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Publication number: 20210231470Abstract: A fluid monitoring assembly includes a conduit having a wall defining a lumen for carrying fluid. A sensor mount is integrally formed with the wall of the conduit and extends generally transverse with respect to a longitudinal axis of the conduit, the sensor mount including an aperture defining an inner surface extending to the lumen. The assembly includes a sensor configured to be removably secured within the sensor mount, the sensor having an elongate body terminating at one end thereof in a sensing portion, the elongate body having a male projection on a portion thereof and configured to rest within the inner surface of the sensor mount. The assembly further includes a housing having first and second portions connected to one another, the housing defining an interior portion configured to encapsulate the conduit, at least a portion of the elongate body of the sensor, and the sensor mount.Type: ApplicationFiled: April 13, 2021Publication date: July 29, 2021Applicant: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates, Dean C. Richards, Scott Bendon
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Patent number: 11022223Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.Type: GrantFiled: February 5, 2019Date of Patent: June 1, 2021Assignee: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates
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Patent number: 11015962Abstract: A fluid monitoring assembly includes a conduit having a wall defining a lumen for carrying fluid. A sensor mount is integrally formed with the wall of the conduit and extends generally transverse with respect to a longitudinal axis of the conduit, the sensor mount including an aperture defining an inner surface extending to the lumen. The assembly includes a sensor configured to be removably secured within the sensor mount, the sensor having an elongate body terminating at one end thereof in a sensing portion, the elongate body having a male projection on a portion thereof and configured to rest within the inner surface of the sensor mount. The assembly further includes a housing having first and second portions connected to one another, the housing defining an interior portion configured to encapsulate the conduit, at least a portion of the elongate body of the sensor, and the sensor mount.Type: GrantFiled: September 13, 2019Date of Patent: May 25, 2021Assignee: Repligen CorporationInventors: Michael C. Gagne, Steven V. Cates, Dean Richards, Scott Bendon