Patents by Inventor Michael C. Hevey

Michael C. Hevey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric filovirus glycoprotein
    Patent number: 7731975
    Abstract: Chimeric GP molecules were constructed which contain portions of both the EBOV and MBGV GP proteins by swapping the subunits between EBOV and MBGV. The chimeric molecules were cloned into an alphavirus replicon which offers the advantage of high protein expression levels in mammalian cells and is a proven vaccine vector. These chimeric molecules fully protected guinea pigs from MBGV challenge, and conversely protected the animals from EBOV challenge. These results indicate that a protective epitope resides within the GP2 subunit of the MBGV GP protein and at least partially within the GP2 subunit of the EBOV GP protein. Additionally these results show that a construction of a single-component bivalent vaccine protective in guinea pigs is achievable.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: June 8, 2010
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Case C. Grogan, Michael C. Hevey, Alan L. Schmaljohn
  • Methods for producing Marburg virus proteins
    Patent number: 7455994
    Abstract: Using the MBGV GP, NP, and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: November 25, 2008
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Michael C. Hevey, Diane I. Negley, Peter Pushko, Jonathan F. Smith, Alan L. Schmaljohn
  • Venezuelan equine encephalitis virus replicon encoding marburg virus proteins
    Patent number: 7090852
    Abstract: Using the MBGV GP, NP, and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: August 15, 2006
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Michael C. Hevey, Diane L. Negley, Peter Pushko, Jonathan F. Smith, Alan L. Schmaljohn
  • Marburg virus vaccines
    Publication number: 20030152590
    Abstract: Using the MBGV GP, NP, and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.
    Type: Application
    Filed: October 9, 2002
    Publication date: August 14, 2003
    Inventors: Michael C. Hevey, Diane L. Negley, Peter Pushko, Jonathan F. Smith, Alan L. Schmaljohn
  • Chimeric filovirus glycoprotein
    Publication number: 20030108560
    Abstract: Chimeric GP molecules were constructed which contain portions of both the EBOV and MBGV GP proteins by swapping the subunits between EBOV and MBGV. The chimeric molecules were cloned into an alphavirus replicon which offers the advantage of high protein expression levels in mammalian cells and is a proven vaccine vector. These chimeric molecules fully protected guinea pigs from MBGV challenge, and conversely protected the animals from EBOV challenge. These results indicate that a protective epitope resides within the GP2 subunit of the MBGV GP protein and at least partially within the GP2 subunit of the EBOV GP protein. Additionally these results show that a construction of a single-component bivalent vaccine protective in guinea pigs is achievable.
    Type: Application
    Filed: January 31, 2002
    Publication date: June 12, 2003
    Inventors: Case C. Grogan, Michael C. Hevey, Alan L. Schmaljohn
  • Marburg virus vaccines
    Patent number: 6517842
    Abstract: The invention here relates to recombinant DNA constructs which comprise a Venezuelan equine encephalitis replicon vector and at least one DNA fragment encoding a protective antigen from the Marburg virus. The DNA constructs are useful for inducing an immune response which is protective against infection with Marburg virus in nonhuman primates.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: February 11, 2003
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Michael C. Hevey, Diane L. Negley, Peter Pushko, Jonathan F. Smith, Alan L. Schmaljohn