Abstract: A biopsy system for harvesting larger volumes of tissue as compared to standard core biopsy needles. The system has a needle with a lumen, an aperture disposed at the distal end of the needle and connected to the lumen, and a cutting mechanism adapted to cut tissue. When the needle is rotated after it is inserted into a target tissue, the cutting mechanism cuts from the tissue and directs the cut tissue portions into the lumen. Multi-bioimpedance measurements are used to guide a needle and direct the application of electricity for cauterizing tissue.

Abstract: An optical device may include a laser component to emit a source beam and an optical component to split the source beam to generate a first beam and a second beam. The optical device may include a multiplexing component to multiplex the first beam and the second beam to form a first multiplexed beam, an optical system to receive the first multiplexed beam and demultiplex the first beam and the second beam, and a scanning component to scan a field of view with the first beam and the second beam and receive the first beam and the second beam reflected from the field of view. The optical system may multiplex the first beam and the second beam reflected from the field of view to form a second multiplexed beam, and a demultiplexing component may demultiplex the first beam and the second beam reflected from the field of view.

Abstract: In some implementations, a thermally-controlled photonic structure may include a suspended region that is suspended over a substrate; a plurality of bridge elements connected to the suspended region and configured to suspend the suspended region over the substrate, where a plurality of openings are defined between the plurality of bridge elements; and at least one heater element having a modulated width disposed on the suspended region. The at least one heater element having the modulated width may include at least one section of a greater width and at least one section of a lesser width. The at least one section of the greater width may be in alignment with an opening of the plurality of openings and the at least one section of the lesser width may be in alignment with a bridge element of the plurality of bridge elements.

Abstract: An optical device may comprise a laser configured to generate an optical beam and a Mach-Zehnder Interferometer (MZI) configured to amplify the optical beam. The MZI may comprise a first coupler and a second coupler connected via a plurality of arms of the MZI. An arm, of the plurality of arms, may provide an optical path for part of the optical beam and may comprise a semiconductor optical amplifier (SOA) configured to amplify the part of the optical beam and a phase shifter configured to adjust a phase of the part of the optical beam.

Abstract: In some implementations, a device may generate a data set including at least modal gain values and modal loss values for a semiconductor optical amplifier (SOA) slice. The device may determine, based on the data set, respective widths for a plurality of slices of an SOA using an autoregressive model. A width, of the respective widths, for a slice, of the plurality of slices, may be associated with a maximum conversion efficiency achievable for the slice at a given current density. The device may generate information indicating a geometry for the SOA based on the respective widths for the plurality of slices.

Abstract: A biopsy system for harvesting larger volumes of tissue as compared to standard core biopsy needles. The system has a needle with a lumen, an aperture disposed at the distal end of the needle and connected to the lumen, and a cutting mechanism adapted to cut tissue. When the needle is rotated after it is inserted into a target tissue, the cutting mechanism cuts from the tissue and directs the cut tissue portions into the lumen. Multi-bioimpedance measurements are used to guide a needle and direct the application of electricity for cauterizing tissue.

Abstract: In some implementations, a thermally-controlled photonic structure may include a suspended region that is suspended over a substrate; a plurality of bridge elements connected to the suspended region and configured to suspend the suspended region over the substrate, where a plurality of openings are defined between the plurality of bridge elements; and at least one heater element having a modulated width disposed on the suspended region. The at least one heater element having the modulated width may include at least one section of a greater width and at least one section of a lesser width. The at least one section of the greater width may be in alignment with an opening of the plurality of openings and the at least one section of the lesser width may be in alignment with a bridge element of the plurality of bridge elements.

Abstract: Optical biopsy staining panels for in vivo or in situ fluorescent staining of optical tissue (or other appropriate tissue), e.g., for the purpose of a direct biopsy such as an optical biopsy. The stain panels may feature a combination of a nuclear stain and a cytoplasmic stain, as a means of functioning as an invivo or in situ hematoxylin and eosin (H&E) stain. Examples of said stains may include anthracyclines such as Daunomcibin, acriflavines like Proflavine, anthracenediones such as Mitoxantrone, phenothiazines like Methylene Blue, and tri- and tetra-heterocyclic dyes like Fluorescein, Phloxine B, Phenol Red, Rose Bengal, Congo Red, and Indigo Carmine.

Abstract: In some implementations, a thermally-controlled photonic structure may include a suspended region that is suspended over a substrate; a plurality of bridge elements connected to the suspended region and configured to suspend the suspended region over the substrate, where a plurality of openings are defined between the plurality of bridge elements; and at least one heater element having a modulated width disposed on the suspended region. The at least one heater element having the modulated width may include at least one section of a greater width and at least one section of a lesser width. The at least one section of the greater width may be in alignment with an opening of the plurality of openings and the at least one section of the lesser width may be in alignment with a bridge element of the plurality of bridge elements.

Abstract: A bioimpedance system is used to obtain multi-bioimpedance measurements for guiding a clinical tool into a body. The system includes a medical instrument that is to be inserted into a body and a plurality of electrodes disposed on a surface of the medical instrument, embedded within the instrument, or both. Each electrode is configured to apply electrical current to the immediate surroundings in contact with the electrode in order to obtain multiple bioimpedance measurements. The bio-impedance measurements are used to guide the medical instrument during insertion and determine positioning and composition of the surrounding environment. The electrodes can also be used to direct application of electricity for cauterizing tissue.

Abstract: A nested Mach-Zehnder device may comprise a parent pre-stage interferometer, a parent interferometer coupled to the parent pre-stage interferometer, a first child pre-stage interferometer, a first child interferometer coupled to the first child pre-stage interferometer, a second child pre-stage interferometer, a second child interferometer coupled to the second child pre-stage interferometer, wherein a phase of each interferometer is electrically adjustable. The nested Mach-Zehnder device may comprise one or more components to: determine a performance parameter associated with a constellation diagram generated by the nested Mach-Zehnder device; determine that the performance parameter does not satisfy a threshold, and cause a phase of at least one pre-stage interferometer, of the parent pre-stage interferometer, the first child pre-stage interferometer, or the second child pre-stage interferometer, to be electrically adjusted to cause the performance parameter to satisfy the threshold.

Abstract: In some implementations, a thermally-controlled photonic structure may include a suspended region that is suspended over a substrate; a plurality of bridge elements connected to the suspended region and configured to suspend the suspended region over the substrate, where a plurality of openings are defined between the plurality of bridge elements; and at least one heater element having a modulated width disposed on the suspended region. The at least one heater element having the modulated width may include at least one section of a greater width and at least one section of a lesser width. The at least one section of the greater width may be in alignment with an opening of the plurality of openings and the at least one section of the lesser width may be in alignment with a bridge element of the plurality of bridge elements.

Abstract: A nested Mach-Zehnder device may comprise a parent pre-stage interferometer, a parent interferometer coupled to the parent pre-stage interferometer, a first child pre-stage interferometer, a first child interferometer coupled to the first child pre-stage interferometer, a second child pre-stage interferometer, a second child interferometer coupled to the second child pre-stage interferometer, wherein a phase of each interferometer is electrically adjustable. The nested Mach-Zehnder device may comprise one or more components to: determine a performance parameter associated with a constellation diagram generated by the nested Mach-Zehnder device; determine that the performance parameter does not satisfy a threshold, and cause a phase of at least one pre-stage interferometer, of the parent pre-stage interferometer, the first child pre-stage interferometer, or the second child pre-stage interferometer, to be electrically adjusted to cause the performance parameter to satisfy the threshold.

Abstract: A photonic integrated circuit may include a substrate and an optical waveguide integrated with the substrate. The optical waveguide may include a bend section, wherein a bend shape of the bend section is defined by a curvature function to suppress waveguide mode conversion.

Abstract: An optical device may comprise a laser configured to generate an optical beam and a Mach-Zehnder Interferometer (MZI) configured to amplify the optical beam. The MZI may comprise a first coupler and a second coupler connected via a plurality of arms of the MZI. An arm, of the plurality of arms, may provide an optical path for part of the optical beam and may comprise a semiconductor optical amplifier (SOA) configured to amplify the part of the optical beam and a phase shifter configured to adjust a phase of the part of the optical beam.

Abstract: An optical device may include a laser component to emit a source beam and an optical component to split the source beam to generate a first beam and a second beam. The optical device may include a multiplexing component to multiplex the first beam and the second beam to form a first multiplexed beam, an optical system to receive the first multiplexed beam and demultiplex the first beam and the second beam, and a scanning component to scan a field of view with the first beam and the second beam and receive the first beam and the second beam reflected from the field of view. The optical system may multiplex the first beam and the second beam reflected from the field of view to form a second multiplexed beam, and a demultiplexing component may demultiplex the first beam and the second beam reflected from the field of view.

Abstract: A photonic integrated circuit may include a substrate and an optical waveguide integrated with the substrate. The optical waveguide may include a bend section, wherein a bend shape of the bend section is defined by a curvature function to suppress waveguide mode conversion.

Abstract: In one aspect, the present disclosure is directed to a system and method for ablating tissue. The method may comprise, for example, aligning a needle of a medical device with the target tissue; piercing tissue adjacent to the target tissue with the needle; sliding into the target tissue a laser fiber moveably disposed within the needle, wherein the needle is hollow and the laser fiber includes a prism; and delivering laser energy through the laser fiber and prism.

Abstract: A biopsy system for harvesting larger volumes of tissue as compared to standard core biopsy needles. The system has a needle with a lumen, an aperture disposed at the distal end of the needle and connected to the lumen, and a cutting mechanism adapted to cut tissue. When the needle is rotated after it is inserted into a target tissue, the cutting mechanism cuts from the tissue and directs the cut tissue portions into the lumen. Multi-bioimpedance measurements are used to guide a needle and direct the application of electricity for cauterizing tissue.

Abstract: A device may include a first photodetector to generate a first current based on an optical power of an optical beam. The device may include a beam splitter to split a portion of the optical beam into a first beam and a second beam. The device may include a wavelength filter to filter the first beam and the second beam. The wavelength filter may filter the second beam differently than the first beam based on a difference between an optical path length of the first beam and an optical path length of the second beam through the wavelength filter. The device may include second and third photodetectors to respectively receive, after the wavelength filter, the first beam and the second beam and to generate respective second currents.