Patents by Inventor Michael C. Lorenz

Michael C. Lorenz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glyoxylate cycle enzymes as targets for antifungal drug development
    Publication number: 20030082669
    Abstract: The present invention relates to methods of identifying a drug that inhibits the virulence of a fungus comprising contacting the fungus with a drug to be assessed and determining whether an enzyme involved in the glyoxylate pathway of the fungus is inhibited in the presence of the drug, wherein if an enzyme of the glyoxylate pathway of the fungus is inhibited in the presence of the drug, then the drug inhibits or virulence of the fungus. In particular embodiments, the present invention relates to methods of identifying a drug that inhibits the virulence of a yeast; methods of identifying a drug that inhibits the virulence of C. albicans; and methods of treating an individual who is susceptible to fungal infection comprising administering to the individual a drug identified by the methods described herein.
    Type: Application
    Filed: February 8, 2002
    Publication date: May 1, 2003
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Michael C. Lorenz, Gerald R. Fink