Patents by Inventor Michael C. McAlpine
Michael C. McAlpine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11854583Abstract: The disclosure describes a head gimbal assembly including a suspension and a damping layer on a surface of the suspension. The suspension may include a slider mount configured to establish mechanical communication with a slider and the layer may be displaced from the slider mount. The layer may be configured to provide passive damping or active damping.Type: GrantFiled: March 29, 2021Date of Patent: December 26, 2023Assignee: Regents of the University of MinnesotaInventors: Michael C. McAlpine, Ghazaleh Haghiashtiani, Zhijie Zhu
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Patent number: 11820061Abstract: A printed structure including a plurality of overlying layers of elongate polymeric filaments stacked on a surface of a substrate. The elongate polymeric filaments are stacked on each other along their lengths to form a liquid impermeable, self-supporting wall. The liquid impermeable self-supporting wall forms a wall angle of about 30° to about 90° with respect to a plane of the surface of the substrate.Type: GrantFiled: November 18, 2020Date of Patent: November 21, 2023Assignees: Regents of the University of Minnesota, U.S. Government as Represented by the Secretary of the ArmyInventors: Michael C. McAlpine, Ruitao Su, Steven J. Koester, Joshua Uzarski
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Patent number: 11794413Abstract: Systems and techniques are described for additive manufacturing, e.g., 3D printing, a component on an unconstrained freeform build surface. The systems and techniques may allow determining a 3D trajectory and/or deformation of a target deposition region on the build surface by determining a relative location of at least one registration feature on the build surface. Control circuitry may control, based on the 3D trajectory and/or deformation and based on a build model of the component, at least one dispenser to cause dispensing of at least one composition from the at least one dispenser in a predetermined pattern on or adjacent to the target deposition region. The predetermined pattern of the composition defines at least one portion of the component.Type: GrantFiled: July 2, 2019Date of Patent: October 24, 2023Assignee: Regents of the University of MinnesotaInventors: Michael C. McAlpine, Zhijie Zhu
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Patent number: 11781101Abstract: A 3D-printed in vitro model biological microenvironment in examples discussed below may have one or more of the following features: (a) a gel matrix 3D-printed scaffold, wherein the gel matrix comprises a chemical composition configured to culture a first type of live cells, (b) a target chemical disposed at one or more locations within the gel matrix, the target chemical forming a chemical depot from which a chemical gradient is created within the gel matrix, (c) a conduit disposed within the gel matrix and defining a lumen comprising a second type of live cells, wherein the conduit is configured to enable at least some of the first type of live cells to migrate through the conduit and facilitate flow of at least: some of the live cells to an outlet of the conduit, or enable introduction of at least one of other cells, Achemical mediators, or drugs into the 3D-printed microenvironment.Type: GrantFiled: November 5, 2019Date of Patent: October 10, 2023Assignee: Regents of the University of MinnesotaInventors: Angela Panoskaltsis-Mortari, Michael C. McAlpine, Fanben Meng
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Publication number: 20230025400Abstract: A system includes a placement head with at least one printing nozzle configured to pick up and detachably hold at least one biological organism; an image acquisition system including a visual inspection system configured to identify at least one target biological organism to be picked up by the printing nozzle of the placement head in a first location, and identify at least one second location for deposit of the at least one target biological organism, wherein the first location is different from the at least one second location; and a robotic motion system that moves the placement head, based on input from the visual inspection system and a distance identification system, from the first location to the at least one second location, such that the placement head deposits the target biological organism at the at least one second location.Type: ApplicationFiled: July 20, 2022Publication date: January 26, 2023Inventors: Michael C. McAlpine, Guebum Han, John C. Bischof, Kanav Khosla, Kieran T. Smith
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Patent number: 11320323Abstract: Techniques are described for additive manufacturing, e.g., 3D printing, stretchable tactile sensors. As described, the techniques may allow the stretchable tactile sensors to be 3D printed under ambient conditions via nanocomposite inks. In various embodiments, sinter-free inks are described with adjustable viscosities and electrical conductivities. Moreover, conductive compositions are described in which micron or submicron-sized silver particles are dispersed in a highly stretchable silicone elastomer. Techniques are described herein in which the inks are used 3D printing process to form tactile sensing platforms and integrated arrays.Type: GrantFiled: September 6, 2018Date of Patent: May 3, 2022Assignee: Regents of the University of MinnesotaInventors: Michael C. McAlpine, Shuangzhuang Guo
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Publication number: 20220072753Abstract: A printed structure including a plurality of overlying layers of elongate polymeric filaments stacked on a surface of a substrate. The elongate polymeric filaments are stacked on each other along their lengths to form a liquid impermeable, self-supporting wall. The liquid impermeable self-supporting wall forms a wall angle of about 30° to about 90° with respect to a plane of the surface of the substrate.Type: ApplicationFiled: November 18, 2020Publication date: March 10, 2022Inventors: Michael C. McAlpine, Ruitao Su, Steven J. Koester, Joshua Uzarski
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Patent number: 11239422Abstract: Disclosed is a process whereby diverse classes of materials can be 3D printed and fully integrated into device components with active properties. An exemplary embodiment shows the seamless interweaving of five different materials, including (1) emissive semiconducting inorganic nanoparticles, (2) an elastomeric matrix, (3) organic polymers as charge transport layers, (4) solid and liquid metal leads, and (5) a UV-adhesive transparent substrate layer, demonstrating the integrated functionality of these materials. Further disclosed is a device for printing these fully integrated 3D devices.Type: GrantFiled: February 5, 2018Date of Patent: February 1, 2022Assignee: TRUSTEES OF PRINCETON UNIVERSITYInventors: Michael C. McAlpine, Yong Lin Kong
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Publication number: 20210312946Abstract: The disclosure describes a head gimbal assembly including a suspension and a damping layer on a surface of the suspension. The suspension may include a slider mount configured to establish mechanical communication with a slider and the layer may be displaced from the slider mount. The layer may be configured to provide passive damping or active damping.Type: ApplicationFiled: March 29, 2021Publication date: October 7, 2021Inventors: Michael C. McAlpine, Ghazaleh Haghiashtiani, Zhijie Zhu
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Publication number: 20200140801Abstract: A 3D-printed in vitro model biological microenvironment in examples discussed below may have one or more of the following features: (a) a gel matrix 3D-printed scaffold, wherein the gel matrix comprises a chemical composition configured to culture a first type of live cells, (b) a target chemical disposed at one or more locations within the gel matrix, the target chemical forming a chemical depot from which a chemical gradient is created within the gel matrix, (c) a conduit disposed within the gel matrix and defining a lumen comprising a second type of live cells, wherein the conduit is configured to enable at least some of the first type of live cells to migrate through the conduit and facilitate flow of at least: some of the live cells to an outlet of the conduit, or enable introduction of at least one of other cells, Achemical mediators, or drugs into the 3D-printed microenvironment.Type: ApplicationFiled: November 5, 2019Publication date: May 7, 2020Inventors: Angela Panoskaltsis-Mortari, Michael C. McAlpine, Fanben Meng
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Publication number: 20200001540Abstract: Systems and techniques are described for additive manufacturing, e.g., 3D printing, a component on an unconstrained freeform build surface. The systems and techniques may allow determining a 3D trajectory and/or deformation of a target deposition region on the build surface by determining a relative location of at least one registration feature on the build surface. Control circuitry may control, based on the 3D trajectory and/or deformation and based on a build model of the component, at least one dispenser to cause dispensing of at least one composition from the at least one dispenser in a predetermined pattern on or adjacent to the target deposition region. The predetermined pattern of the composition defines at least one portion of the component.Type: ApplicationFiled: July 2, 2019Publication date: January 2, 2020Inventors: Michael C. McAlpine, Zhijie Zhu
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Patent number: 10405963Abstract: The present invention includes biomimetic nerve conduits that can be used as nerve regeneration pathways. The present invention further provides methods of preparing and using biomimetic nerve conduits. The disclosed compositions and methods have a broad range of potential applications, for example replacing a missing or damaged section of a nerve pathway of a mammal.Type: GrantFiled: November 16, 2015Date of Patent: September 10, 2019Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Michael C. McAlpine, Blake N. Johnson
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Publication number: 20190072439Abstract: Techniques are described for additive manufacturing, e.g., 3D printing, stretchable tactile sensors. As described, the techniques may allow the stretchable tactile sensors to be 3D printed under ambient conditions via nanocomposite inks. In various embodiments, sinter-free inks are described with adjustable viscosities and electrical conductivities. Moreover, conductive compositions are described in which micron or submicron-sized silver particles are dispersed in a highly stretchable silicone elastomer. Techniques are described herein in which the inks are used 3D printing process to form tactile sensing platforms and integrated arrays.Type: ApplicationFiled: September 6, 2018Publication date: March 7, 2019Inventors: Michael C. McAlpine, Shuangzhuang Guo
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Publication number: 20180159037Abstract: Disclosed is a process whereby diverse classes of materials can be 3D printed and fully integrated into device components with active properties. An exemplary embodiment shows the seamless interweaving of five different materials, including (1) emissive semiconducting inorganic nanoparticles, (2) an elastomeric matrix, (3) organic polymers as charge transport layers, (4) solid and liquid metal leads, and (5) a UV-adhesive transparent substrate layer, demonstrating the integrated functionality of these materials. Further disclosed is a device for printing these fully integrated 3D devices.Type: ApplicationFiled: February 5, 2018Publication date: June 7, 2018Applicant: The Trustees of Princeton UniversityInventors: Michael C. McAlpine, Yong Lin Kong
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Patent number: 9887356Abstract: Disclosed is a process whereby diverse classes of materials can be 3D printed and fully integrated into device components with active properties. An exemplary embodiment shows the seamless interweaving of five different materials, including (1) emissive semiconducting inorganic nanoparticles, (2) an elastomeric matrix, (3) organic polymers as charge transport layers, (4) solid and liquid metal leads, and (5) a UV-adhesive transparent substrate layer, demonstrating the integrated functionality of these materials. Further disclosed is a device for printing these fully integrated 3D devices.Type: GrantFiled: January 21, 2016Date of Patent: February 6, 2018Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Michael C. McAlpine, Yong Lin Kong
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Publication number: 20170135802Abstract: The present invention includes biomimetic nerve conduits that can be used as nerve regeneration pathways. The present invention further provides methods of preparing and using biomimetic nerve conduits. The disclosed compositions and methods have a broad range of potential applications, for example replacing a missing or damaged section of a nerve pathway of a mammal.Type: ApplicationFiled: November 16, 2015Publication date: May 18, 2017Inventors: MICHAEL C. McALPINE, BLAKE N. JOHNSON
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Patent number: 9517128Abstract: A bioelectronic device and method of making is disclosed. The device includes a scaffold formed via 3D printing. The device also includes a biologic and an electronic device formed via 3D printing, the biologic and electronic device being interweaved with or coupled to the scaffold. The electronic component may e.g., include at least one of hard conductors, soft conductors, insulators and semiconductors. The scaffold may be formed of at least one of synthetic polymers and natural biological polymers. The biologic may include at least one of animal cells, plant cells, cellular organelles, proteins and DNA (including RNA).Type: GrantFiled: March 10, 2014Date of Patent: December 13, 2016Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Michael C. McAlpine, Manu Sebastian-Mannoor, Yong Lin Kong, Blake N Johnson
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Patent number: 9502638Abstract: A method of making a flexible piezoelectric structure is disclosed. A piezoelectric film is deposited by film deposition on a planar substrate. A biocompatible flexible substrate is contacted with the piezoelectric film. The piezoelectric film and biocompatible flexible substrate are separated from the planar substrate, and the piezoelectric film remaining is attached to the biocompatible flexible substrate.Type: GrantFiled: August 3, 2012Date of Patent: November 22, 2016Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Michael C. McAlpine, Yi Qi
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Publication number: 20160223538Abstract: A biosensor and method of making are disclosed. The biosensor is configured to detect a target and may include a peptide immobilized on a sensing component, the sensing component having an anode and a cathode. The immobilized peptide may comprise an antimicrobial peptide binding motif for the target. The sensing component has an electrical conductivity that changes in response to binding of the immobilized peptide to the target. The immobilized peptide may bind one or more targets selected from the list consisting of: bacteria, Gram-negative bacteria, Gram-positive bacteria, pathogens, protozoa, fungi, viruses, and cancerous cells. The biosensor may have a display with a readout that is responsive to changes in electrical conductivity of the sensing component. The display unit may be wirelessly coupled to the sensing component. A resonant circuit with an inductive coil may be electrically coupled to the sensing component.Type: ApplicationFiled: May 11, 2015Publication date: August 4, 2016Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Michael C. McAlpine, Manu Sebastian Mannoor
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Publication number: 20160218287Abstract: Disclosed is a process whereby diverse classes of materials can be 3D printed and fully integrated into device components with active properties. An exemplary embodiment shows the seamless interweaving of five different materials, including (1) emissive semiconducting inorganic nanoparticles, (2) an elastomeric matrix, (3) organic polymers as charge transport layers, (4) solid and liquid metal leads, and (5) a UV-adhesive transparent substrate layer, demonstrating the integrated functionality of these materials. Further disclosed is a device for printing these fully integrated 3D devices.Type: ApplicationFiled: January 21, 2016Publication date: July 28, 2016Applicant: The Trustees of Princeton UniversityInventors: Michael C. McAlpine, Yong Lin Kong