Patents by Inventor Michael C. Myers

Michael C. Myers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED RELAXIN POLYPEPTIDES COMPRISING A PHARMACOKINETIC ENHANCER AND USES THEREOF
    Publication number: 20180222960
    Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
    Type: Application
    Filed: February 8, 2018
    Publication date: August 9, 2018
    Inventors: Gene M. DUBOWCHIK, Olafur S. Gudmundsson, Xiaojun Han, R. Michael Lawrence, Dasa Lipovsek, Cort S. Madsen, Claudio Mapelli, Paul E. Morin, Michael C. Myers
  • 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists
    Patent number: 10011594
    Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: July 3, 2018
    Assignee: Bristol-Myers Squibb Company
    Inventors: James A. Johnson, Soong-Hoon Kim, R. Michael Lawrence, Michael C. Myers, Hannguang J. Chao, Monique Phillips, Ji Jiang
  • 6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS
    Publication number: 20170275272
    Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
    Type: Application
    Filed: March 24, 2017
    Publication date: September 28, 2017
    Inventors: Zulan Pi, Donna M. Bilder, Robert Paul Brigance, Heather Finlay, Wen Jiang, James A. Johnson, R. Michael Lawrence, Wei Meng, Michael C. Myers, Monique Phillips, George O. Tora, Xiaojun Zhang
  • 4-HYDROXY-3-(HETEROARYL)PYRIDINE-2-ONE APJ AGONISTS
    Publication number: 20160355507
    Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
    Type: Application
    Filed: June 2, 2016
    Publication date: December 8, 2016
    Inventors: James A. Johnson, Soong-Hoon Kim, R. Michael Lawrence, Michael C. Myers, Hannguang J. Chao, Monique Phillips, Ji Jiang
  • Inhibitors of Human Cathepsin L, Cathepsin B, and Cathepsin S
    Publication number: 20110207726
    Abstract: The present invention is directed to novel protease inhibitors that are specific for cathepsin L, cathepsin B, and cathepsin S. Accordingly, the present invention encompasses compositions and methods for treating and preventing diseases and disorders associated with cathepsin L, cathepsin B, or cathepsin S function or activity.
    Type: Application
    Filed: April 17, 2009
    Publication date: August 25, 2011
    Inventors: Scott L. Diamond, Mary Pat Beavers, Donna Huryn, Michael C. Myers, Amos B. Smith, Parag P. Shah, Zhuqing Liu
  • Compounds and related methods for mutant p53 reactivation
    Patent number: 7829304
    Abstract: Ketoamine compounds and related methods for reactivation of tumor suppressor protein p53.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: November 9, 2010
    Assignee: Northwestern University
    Inventors: Daniel H. Appella, Michael C. Myers
  • Compounds and Related Methods for Mutant p53 Reactivation
    Publication number: 20080206805
    Abstract: Ketoamine compounds and related methods for reactivation of tumor suppressor protein p53.
    Type: Application
    Filed: February 11, 2008
    Publication date: August 28, 2008
    Inventors: Daniel H. Appella, Michael C. Myers
  • Compounds and related methods for mutant p53 reactivation
    Patent number: 7329775
    Abstract: Ketoamine compounds and related methods for reactivation of tumor suppressor protein p53.
    Type: Grant
    Filed: November 1, 2004
    Date of Patent: February 12, 2008
    Assignee: Northwestern University
    Inventors: Daniel H. Appella, Michael C. Myers