Patents by Inventor Michael C. Needels

Michael C. Needels has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-7R??c ligand immunoglobulin fusion proteins
    Patent number: 11999771
    Abstract: IL-7R??c ligands and IL-7R??c IgG-Fc fusion proteins are disclosed. The IL-7R??c ligands and IL-7R??c IgG-Fc fusion proteins are IL-7R agonists.
    Type: Grant
    Filed: December 5, 2022
    Date of Patent: June 4, 2024
    Assignee: Medikine, Inc.
    Inventors: William J. Dower, Ronald W. Barrett, Michael C. Needels, Steven E. Cwirla, Alice V. Bakker, Inkyung Park
  • IL-7R-?-? binding compounds
    Patent number: 11965015
    Abstract: IL-7R??c binding compounds and pharmaceutical compositions comprising the IL-7R??c binding compounds are disclosed. IL-7R??c bonding compounds can act as IL-7R agonists and are useful in treating cancer, viral diseases, autoimmune diseases, and inflammatory diseases.
    Type: Grant
    Filed: July 11, 2023
    Date of Patent: April 23, 2024
    Assignee: Medikine, Inc.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • IL-7R??c binding compounds
    Patent number: 11746139
    Abstract: IL-7R??c binding compounds and pharmaceutical compositions comprising the IL-7R??c binding compounds are disclosed. IL-7R??c bonding compounds can act as IL-7R agonists and are useful in treating cancer, viral diseases, autoimmune diseases, and inflammatory diseases.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: September 5, 2023
    Assignee: MEDIKINE, INC.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • IL-2R-?? binding compounds
    Patent number: 11718654
    Abstract: IL-2R??c binding compounds, and pharmaceutical compositions comprising the IL-2R??c binding compounds are disclosed. IL-2R??c binding compounds can act as IL-2R agonists and are useful in treating cancer, autoimmune diseases and inflammatory diseases.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: August 8, 2023
    Assignee: MEDIKINE, INC.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • IL-2alpha receptor subunit binding compounds
    Patent number: 11692009
    Abstract: Peptidyl IL-2R? ligands and compounds comprising the IL-2R? ligands are disclosed. The IL-2R? ligands and compounds such as synthetic monomers, homodimers, or heteromers and recombinant fusion proteins comprising the IL-2R? ligands can be used as targeting or imaging agents, as diagnostics or to treat cancers and autoimmune diseases.
    Type: Grant
    Filed: January 5, 2022
    Date of Patent: July 4, 2023
    Assignee: MEDIKINE, INC.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • IL-2Rgamma binding compounds
    Patent number: 11548914
    Abstract: IL-2R? ligands and IL-2R?c ligands and compounds comprising the ligands are disclosed. The ligands and compounds such as heterodimers and fusion proteins comprising the IL-2R? ligands and/or the IL-2R?c ligands can be IL-2 receptor agonists.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: January 10, 2023
    Assignee: MEDIKINE, INC.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • IL-2RBETA binding compounds
    Patent number: 11358986
    Abstract: IL-2R? ligands and IL-2R?c ligands and compounds comprising the ligands are disclosed. The ligands and compounds such as heterodimers and fusion proteins comprising the IL-2R? ligands and/or the IL-2R?c ligands can be IL-2 receptor agonists.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: June 14, 2022
    Assignee: MEDIKINE, INC.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • IL-7R-? binding compounds
    Patent number: 11254729
    Abstract: IL-7R? ligands and compounds comprising IL-7R? ligands are disclosed. The IL-7R? binding compounds include fusion proteins comprising the IL-7R? ligands and can act as IL-7R agonists.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: February 22, 2022
    Assignee: MEDIKINE, INC.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • Dual IL-2R and IL-7R binding compounds
    Patent number: 11248030
    Abstract: Dual receptor binding compounds comprising IL-2R?, IL-7R?, and R?c ligands, and pharmaceutical compositions comprising the dual receptor binding compounds are disclosed. The dual receptor binding compounds can act as IL-2R and IL-7R agonists and are useful in treating cancer, viral diseases, autoimmune diseases, and inflammatory diseases.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: February 15, 2022
    Assignee: MEDIKINE, INC.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • IL-2alpha receptor subunit binding compounds
    Patent number: 11248025
    Abstract: Peptidyl IL-2R? ligands and compounds comprising the IL-2R? ligands are disclosed. The IL-2R? ligands and compounds such as synthetic monomers, homodimers, or heteromers and recombinant fusion proteins comprising the IL-2R? ligands can be used as targeting or imaging agents, as diagnostics or to treat cancers and autoimmune diseases.
    Type: Grant
    Filed: June 2, 2020
    Date of Patent: February 15, 2022
    Assignee: MEDIKINE, INC.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • IL-2RBeta binding compounds
    Patent number: 10703776
    Abstract: IL-2R? ligands and IL-2R?c ligands and compounds comprising the ligands are disclosed. The ligands and compounds such as heterodimers and fusion proteins comprising the IL-2R? ligands and/or the IL-2R?c ligands can be IL-2 receptor agonists.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: July 7, 2020
    Assignee: MEDIKINE, INC.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • IL-2R? binding compounds
    Patent number: 10689417
    Abstract: IL-2R? ligands and IL-2R?c ligands and compounds comprising the ligands are disclosed. The ligands and compounds such as heterodimers and fusion proteins comprising the IL-2R? ligands and/or the IL-2R?c ligands can be IL-2 receptor agonists.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: June 23, 2020
    Assignee: MEDIKINE, INC.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • IL-2RGAMMA BINDING COMPOUNDS
    Publication number: 20200040036
    Abstract: IL-2R? ligands and IL-2R?c ligands and compounds comprising the ligands are disclosed. The ligands and compounds such as heterodimers and fusion proteins comprising the IL-2R? ligands and/or the IL-2R?c ligands can be IL-2 receptor agonists.
    Type: Application
    Filed: August 5, 2019
    Publication date: February 6, 2020
    Applicant: MEDIKINE, INC.
    Inventors: William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
  • Peptide nucleic acids as tags in encoded libraries
    Publication number: 20030228619
    Abstract: Methods of screening a library of compounds are disclosed herein. The methods include providing a library of differing complexes. Each complex includes a compound and a peptide nucleic acid tag encoding one or more synthesis steps by which the compound was made, the compounds and the tags encoding them differing between the different complexes. Usually, the complex is cleavably bound to a support. One preferred support is polyethylene glycol (PEG), and optionally the PEG support is attached to a dendrimer. The library of differing complexes is then contacted with a molecular target (e.g., a receptor or enzyme). A complex(es) that bind to the target is isolated. The isolated complex(es) is contacted with a nucleic acid that hybridizes to the tag of the complex. The tag is decoded from the identity of the nucleic acid that hybridizes to the tag, thereby identifying the compound which binds to the target.
    Type: Application
    Filed: May 22, 2003
    Publication date: December 11, 2003
    Applicant: XenoPort, Inc.
    Inventor: Michael C. Needels
  • Method of synthesizing diverse collections of oligomers
    Patent number: 6416949
    Abstract: A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties.
    Type: Grant
    Filed: February 24, 1999
    Date of Patent: July 9, 2002
    Assignee: Affymax, Inc.
    Inventors: William Dower, Ronald W. Barrett, Mark A. Gallop, Michael C. Needels
  • Method of synthesizing diverse collections of oligomers
    Patent number: 6140493
    Abstract: A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: October 31, 2000
    Assignee: Affymax Technologies N.V.
    Inventors: William J. Dower, Ronald W. Barrett, Mark A. Gallop, Michael C. Needels
  • Tagged synthetic oligomer libraries
    Patent number: 5770358
    Abstract: A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: June 23, 1998
    Assignee: Affymax Technologies N.V.
    Inventors: William J. Dower, Ronald W. Barrett, Mark A. Gallop, Michael C. Needels
  • Synthesizing and screening molecular diversity
    Patent number: 5639603
    Abstract: A general stochastic method for synthesizing compounds can be used to generate large collections of tagged compounds that can be screened to identify and isolate compounds with useful properties.
    Type: Grant
    Filed: November 2, 1993
    Date of Patent: June 17, 1997
    Assignee: Affymax Technologies N.V.
    Inventors: William J. Dower, Ronald W. Barrett, Mark A. Gallop, Michael C. Needels