Patents by Inventor Michael C. Nelson

Michael C. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Morphometric detection of malignancy associated change
    Patent number: 11551043
    Abstract: A method for a system and method for morphometric detection of malignancy associated change (MAC) is disclosed including the acts of obtaining a sample; imaging cells to produce 3D cell images for each cell; measuring a plurality of different structural biosignatures for each cell from its 3D cell image to produce feature data; analyzing the feature data by first using cancer case status as ground truth to supervise development of a classifier to test the degree to which the features discriminate between cells from normal or cancer patients; using the analyzed feature data to develop classifiers including, a first classifier to discriminate normal squamous cells from normal and cancer patients, a second classifier to discriminate normal macrophages from normal and cancer patients, and a third classifier to discriminate normal bronchial columnar cells from normal and cancer patients.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: January 10, 2023
    Assignee: VISIONGATE, INC.
    Inventors: Michael G. Meyer, Laimonas Kelbauskas, Rahul Katdare, Daniel J. Sussman, Timothy Bell, Alan C. Nelson
  • Morphometric genotyping of cells in liquid biopsy using optical tomography
    Patent number: 11545237
    Abstract: A classification training method for training classifiers adapted to identify specific mutations associated with different cancer including identifying driver mutations. First cells from mutation cell lines derived from conditions having the number of driver mutations are acquired and 3D image feature data from the number of first cells is identified. 3D cell imaging data from the number of first cells and from other malignant cells is generated, where cell imaging data includes a number of first individual cell images. A second set of 3D cell imaging data is generated from a set of normal cells where the number of driver mutations are expected to occur, where the second set of cell imaging data includes second individual cell images. Supervised learning is conducted based on cell line status as ground truth to generate a classifier.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: January 3, 2023
    Assignee: VISIONGATE, INC.
    Inventors: Michael G. Meyer, Daniel J. Sussman, Rahul Katdare, Laimonas Kelbauskas, Alan C. Nelson, Randall Mastrangelo
  • Feed supplement bolus with active yeast
    Patent number: 11523625
    Abstract: A ruminant dietary supplement in the form of a pressed shelf-stable solid pill or bolus that effervesces when administered into the reticulum of a ruminant and releases calcium and dried active yeast.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: December 13, 2022
    Assignee: TechMix, LLC
    Inventors: Peter H. Franz, Marty J. Nelson, Michael L. Nelson, Bradley Welding Kolstad, Nathan C. Upah, David J. Muysson, Dennis M. McKilligan
  • Methods and systems for J-coupled nuclear magnetic resonance
    Patent number: 11525879
    Abstract: A nuclear magnetic resonance (NMR) system is configured to detect combinatorial signatures stemming from homonuclear and heteronuclear J-couplings. The system comprises a pre-polarization system, a detector, and NMR electronics, wherein the detector includes an NMR magnet with a magnetic field of strength between 300 mT and 10 ?T.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: December 13, 2022
    Assignee: Triad National Security, LLC
    Inventors: Robert F. Williams, Michelle A. Espy, Derrick C. Kaseman, Jacob Luther Yoder, Per Erik Magnelind, Algis V. Urbaitis, Michael Timothy Janicke, Ryszard Michalczyk, Jurgen G. Schmidt, Pulak Nath, Scarlett Widgeon Paisner, Tammie Renee Nelson
  • Transgenic plants with enhanced agronomic traits
    Patent number: 11479783
    Abstract: This invention provides recombinant DNA constructs, transgenic plant nuclei and cells with such recombinant DNA construct for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: October 25, 2022
    Assignee: Monsanto Technology LLC
    Inventors: Mark Scott Abad, Jeffrey E. Ahrens, Alice Clara Augustine, Erin Bell, Robert J. Bensen, Paolo Castiglioni, Richard Eric Cerny, Shobha Char, Xianfeng Chen, Jaishree M. Chittoor-Vijayanath, Maureen Daley, Jill Deikman, Molian Deng, Todd DeZwaan, Stephen Duff, Michael D. Edgerton, Bradon J. Fabbri, Jason Fenner, Karen Gabbert, Barry S. Goldman, Deborah J. Hawkins, Steve He, Richard Johnson, Balasulojini Karunanandaa, Garrett J. Lee, Paul Loida, Savitha Madappa, Robert J. Meister, Donald E. Nelson, Anand Pandravada, Obed Patty, Ming Peng, Marie Petracek, Rajani Monnanda Somaiah, Dhanalakshmi Ramachandra, Monica P. Ravanello, Thomas G. Ruff, Rick A. Sanders, Beth Savidge, Steven H. Schwartz, Padmini Sudarshana, Jindong Sun, Rebecca L. Thompson-Mize, Virginia Ursin, Dale L. Vai, Srikanth Venkatachalayya, Tymagondlu V. Venkatesh, Kammaradi Vidya, K. Vijayalakshmi, Todd C. Weber, Jingrui Wu, Zhidong Xie, Wei Zheng
  • TREATMENT MEDIA DELIVERY DEVICE AND METHODS FOR TARGETED DELIVERY THEREOF
    Publication number: 20220280759
    Abstract: Described embodiments are directed to a device for delivery of activatable compounds to a patients lumen, such as in transcatheter procedures. More specifically, described embodiments are directed toward delivery devices operable to deliver the activatable compounds and to activate the compounds by light. Such delivery devices include a balloon (14) having a treatment zone (16) for activatable compound delivery and/or activation and non-treatment zones (18) that block activatable compound delivery and/or activation for controlled delivery and activation of the activatable compounds.
    Type: Application
    Filed: August 7, 2020
    Publication date: September 8, 2022
    Inventors: Merrill J. Birdno, Michael R. Broyles, Jeffrey J. Honer, Christopher Hyzin, Brandon C. Short, Jared S. Nelson
  • METHODS, SYSTEMS AND APPARATUS FOR REDUCING WASTE HEAT AND/OR LIGHT IN FIBER LASERS
    Publication number: 20220255296
    Abstract: In an example, the disclosed technology includes a laser source, comprising a plurality of pump elements configured to generate laser light, a controller coupled to the plurality of pump elements, configured to select individual drive current levels to be provided to respective ones of the plurality of pump elements responsive to a request for a laser power level and at least one power supply coupled to one or more of the plurality of pump elements for driving individual pump elements at selected drive currents.
    Type: Application
    Filed: June 15, 2020
    Publication date: August 11, 2022
    Applicant: NLIGHT, INC.
    Inventors: Tyson L. LOWDER, Robert Joseph FOLEY, Michael C. NELSON
  • MODULAR HUMERAL HEAD
    Publication number: 20220031464
    Abstract: A humeral head assembly is provided that includes an articular body and a coupler. The articular body includes a coupling portion disposed on a side of the articular body opposite an articular surface. The coupling portion includes a continuous zone of eccentricity adjustment. The coupler portion optionally includes one or more than one discrete position site. The coupler includes a first portion and a second portion opposite the first portion. The first portion is configured to mate with the coupling portion and the second portion is configured to mate with another member of a joint prosthesis. A coupling portion with the continuous range of eccentricity adjustment can be provided on a bone anchor and the eccentricity of another component can be selected by motion of a coupler, such as a tray for reverse humeral assemblies, along the coupling portion of the anchor.
    Type: Application
    Filed: October 2, 2018
    Publication date: February 3, 2022
    Applicant: HOWMEDICA OSTEONICS CORP.
    Inventors: Kevin P. KNOX, Austin Wyatt MUTCHLER, Michael C. NELSON, David R. STUMP
  • Laser burst logging systems and methods
    Patent number: 11239623
    Abstract: A burst logging system logs and transmits to a local or remote computing system event data related to errors in and or potential failures of laser system components. The system further provides for capturing data at different rates from different sensors, synchronization of data capture associated with system events and the possibility for aggregation of data from multiple systems, which can in turn be leveraged to predict and or remediate future system events.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: February 1, 2022
    Assignee: nLIGHT, Inc.
    Inventor: Michael C. Nelson
  • MODULAR HUMERAL HEAD
    Publication number: 20210228372
    Abstract: An articular component is provided that includes an articular body having an articular surface, a bone anchor, a coupling portion, and a coupler. The bone anchor includes a distal end configured to be lodged in a bone and a proximal face. The coupling portion includes a recessed area in the articular body disposed between the articular surface and the distal end of the bone anchor. The coupler includes a first portion configured to mate with the coupling portion at a selected rotational position, and a second portion opposite the first portion, wherein the second portion is configured to couple, directly or indirectly, the articular body with the bone anchor.
    Type: Application
    Filed: April 15, 2021
    Publication date: July 29, 2021
    Applicant: TORNIER, INC.
    Inventors: Kevin P. KNOX, Austin Wyatt MUTCHLER, Michael C. NELSON, David R. STUMP
  • LASER BURST LOGGING SYSTEMS AND METHODS
    Publication number: 20200220314
    Abstract: A burst logging system logs and transmits to a local or remote computing system event data related to errors in and or potential failures of laser system components. The system further provides for capturing data at different rates from different sensors, synchronization of data capture associated with system events and the possibility for aggregation of data from multiple systems, which can in turn be leveraged to predict and or remediate future system events.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 9, 2020
    Applicant: nLIGHT, Inc.
    Inventor: Michael C. Nelson
  • Laser burst logging systems and methods
    Patent number: 10608397
    Abstract: A burst logging system logs and transmits to a local or remote computing system event data related to errors in and or potential failures of laser system components. The system further provides for capturing data at different rates from different sensors, synchronization of data capture associated with system events and the possibility for aggregation of data from multiple systems, which can in turn be leveraged to predict and or remediate future system events.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: March 31, 2020
    Assignee: nLIGHT, Inc.
    Inventor: Michael C. Nelson
  • ORTHOPAEDIC SURGICAL INSTRUMENT FOR AN ACETABULAR PROSTHETIC COMPONENT
    Publication number: 20190388241
    Abstract: An orthopaedic surgical instrument includes an insertion tool having a threaded end configured to engage an acetabular cup. A gauge is provided including a pair of clamp arms configured to engage the insertion tool to secure the gauge to the insertion tool. A clamping lever is rotatable to move the clamp arms into engagement with the insertion tool. A visual indicator is configured to indicate a predetermined orientation of the insertion tool relative to a patient's body.
    Type: Application
    Filed: June 26, 2018
    Publication date: December 26, 2019
    Inventors: Michael C. NELSON, Darron G. PEDDLE
  • LASER BURST LOGGING SYSTEMS AND METHODS
    Publication number: 20190280447
    Abstract: A burst logging system logs and transmits to a local or remote computing system event data related to errors in and or potential failures of laser system components. The system further provides for capturing data at different rates from different sensors, synchronization of data capture associated with system events and the possibility for aggregation of data from multiple systems, which can in turn be leveraged to predict and or remediate future system events.
    Type: Application
    Filed: March 5, 2019
    Publication date: September 12, 2019
    Applicant: nLIGHT, Inc.
    Inventor: Michael C. Nelson
  • Method for actively controlling the optical output of a seed laser
    Patent number: 9478931
    Abstract: Seed pulse generators for fiber amplifier systems include a seed pump controller coupled to a seed pump laser diode. A photodetector is situated to detect seed pulse generation, and is coupled to the seed pump controller so that seed pumping is decreased upon pulse detection. For a laser diode pump source, a pump current can be pulsed to produce a seed pulse and then decreased to a bias level such as a DC bias current that is less than a pump laser threshold current. Single seed pulses can be generated with reduced pulse jitter.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: October 25, 2016
    Assignee: nLight Photonics Corporation
    Inventors: Gary L. Burkholder, Michael C. Nelson, Michael Brinker
  • Water flow control device for rotary sprinkler
    Patent number: 5647541
    Abstract: A fluid flow regulator readily attachable between a rotary sprinkler and a fluid conduit for regulating the water flow and pressure to the sprinkler to irrigate an irregular pattern such as a square. The regulator icludes a body having a streamlined channel leading to a straight through flow variable orifice and being connectable with a respective fluid port member of the sprinkler and the conduit. A rotatable port piece mounted in the body has a straight through flow port, centered on the axis of rotation and communicating with the straight through flow orifice of the body. This port leads to a streamlined channel which exits into the sprinkler shaft. The port piece has a means for coupling rotational energy from the sprinkler. The port and orifice have an identical design such as a four point star or equilateral concaved octagon adapted for watering in a square pattern. The rotational position of the port piece in relation to the body regulates the flow of water.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: July 15, 1997
    Inventor: Michael C. Nelson
  • Desk organizer
    Patent number: D531225
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: October 31, 2006
    Assignee: Staples, The Office Superstore, LLC
    Inventors: Michael Kent, David Gerard D'Angelo, Michael C. Nelson, Robert A. George