Patents by Inventor Michael C. Pirrung

Michael C. Pirrung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoproteasome inhibitor analogs
    Patent number: 10584105
    Abstract: The disclosure provides for compounds having immunoproteasome inhibitory activity, and pharmaceutical compositions made thereof. The disclosure further provides for the use of the compounds and compositions in treating various diseases and disorders in a subject that are associated with immunoproteasome activity, including inflammatory disorders, autoimmune disorders, hematological disorders, and neurodegenerative disorders.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: March 10, 2020
    Assignees: The Regents of the University of California, Board of Trustees of the Michigan State University
    Inventors: Michael C. Pirrung, Nicole A. Bakas, Andre Bachmann
  • IMMUNOPROTEASOME INHIBITOR ANALOGS
    Publication number: 20190047969
    Abstract: The disclosure provides for compounds having immunoproteasome inhibitory activity, and pharmaceutical compositions made thereof. The disclosure further provides for the use of the compounds and compositions in treating various diseases and disorders in a subject that are associated with immunoproteasome activity, including inflammatory disorders, autoimmune disorders, hematological disorders, and neurodegenerative disorders.
    Type: Application
    Filed: March 10, 2017
    Publication date: February 14, 2019
    Inventors: Michael C. Pirrung, Nicole A. Bakas, Andre Bachmann
  • Synthesis of syrbactin proteasome inhibitors
    Patent number: 9783572
    Abstract: The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: October 10, 2017
    Assignee: The Regents of the University of California
    Inventor: Michael C. Pirrung
  • SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS
    Publication number: 20160347790
    Abstract: The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.
    Type: Application
    Filed: June 2, 2016
    Publication date: December 1, 2016
    Inventor: Michael C. Pirrung
  • Substituted macrocyclic compounds having proteasome inhibitory activity
    Patent number: 9399627
    Abstract: The disclosure provides for novel compounds which have proteasome inhibitory activity, pharmaceutical compositions made thereof, and methods of use thereof to treat various disorders, including cancer and nonmalignant tumors.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: July 26, 2016
    Assignee: The Regents of the University of California
    Inventor: Michael C. Pirrung
  • Synthesis of syrbactin proteasome inhibitors
    Patent number: 9359309
    Abstract: The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: June 7, 2016
    Assignee: The Regents of the University of California
    Inventor: Michael C. Pirrung
  • SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS
    Publication number: 20160108007
    Abstract: The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.
    Type: Application
    Filed: December 28, 2015
    Publication date: April 21, 2016
    Inventor: Michael C. Pirrung
  • Synthesis of syrbactin proteasome inhibitors
    Patent number: 9221772
    Abstract: The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: December 29, 2015
    Assignee: The Regents of the University of California
    Inventor: Michael C. Pirrung
  • SUBSTITUTED MACROCYCLIC COMPOUNDS HAVING PROTEASOME INHIBITORY ACTIVITY
    Publication number: 20150141392
    Abstract: The disclosure provides for novel compounds which have proteasome inhibitory activity, pharmaceutical compositions made thereof, and methods of use thereof to treat various disorders, including cancer and nonmalignant tumors.
    Type: Application
    Filed: June 14, 2013
    Publication date: May 21, 2015
    Inventor: Michael C. Pirrung
  • SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS
    Publication number: 20130065872
    Abstract: The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.
    Type: Application
    Filed: December 3, 2010
    Publication date: March 14, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Michael C. Pirrung
  • Small molecule insulin mimetics absent quinones
    Patent number: 8222279
    Abstract: Compounds of Formula I are described along with pharmaceutical formulations thereof, and methods of treating disorders such as diabetes and neurodegenerative diseases with such compounds.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: July 17, 2012
    Assignee: Duke University
    Inventor: Michael C. Pirrung
  • SMALL MOLECULE INSULIN MIMETICS ABSENT QUINONES
    Publication number: 20110028519
    Abstract: Compounds of Formula I are described along with pharmaceutical formulations thereof, and methods of treating disorders such as diabetes and neurodegenerative diseases with such compounds.
    Type: Application
    Filed: October 11, 2010
    Publication date: February 3, 2011
    Inventor: Michael C. Pirrung
  • Small molecule insulin mimetics absent quinones
    Patent number: 7834050
    Abstract: Compounds of Formula I are described along with pharmaceutical formulations thereof, and methods of treating disorders such as diabetes and neurodegenerative diseases with such compounds.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: November 16, 2010
    Assignee: Duke University
    Inventor: Michael C. Pirrung
  • Nucleotides and analogs having photoremovable protecting groups
    Patent number: 7087732
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: December 28, 2001
    Date of Patent: August 8, 2006
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
  • Heterocyclic quinones as pharmaceutical agents
    Patent number: 7057052
    Abstract: Pyrrolylquinones and indolylquinones useful for treating diseases such as neurodegenerative disease, viral infections and proliferative disease are described, along with methods of making such compounds and pharmaceutical formulations containing such compounds.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: June 6, 2006
    Assignee: Duke University
    Inventors: Michael C. Pirrung, Johannes Rudolph
  • Apparatus comprising polymers
    Patent number: 6955915
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: October 18, 2005
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Paul D. Hoeprich, Jr.
  • Polypeptide arrays
    Patent number: 6919211
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: July 19, 2005
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, J. Leighton Read, Lubert Stryer, Michael C. Pirrung
  • Methods for polymer synthesis
    Patent number: 6747143
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: June 8, 2004
    Assignee: Affymetrix, Inc.
    Inventors: Lubert Stryer, Stephen P. A. Fodor, J. Leighton Read, Michael C. Pirrung
  • Heterocyclic quinones as pharmaceutical agents
    Publication number: 20040063774
    Abstract: Pyrrolylquinones and indolylquinones useful for treating diseases such as neurodegenerative disease, viral infections and proliferative disease are described, along with methods of making such compounds and pharmaceutical formulations containing such compounds.
    Type: Application
    Filed: September 26, 2002
    Publication date: April 1, 2004
    Inventors: Michael C. Pirrung, Johannes Rudolph
  • Support bound probes and methods of analysis using the same
    Publication number: 20040038268
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Application
    Filed: June 4, 2003
    Publication date: February 26, 2004
    Applicant: Affymetrix, Inc.
    Inventors: Michael C. Pirrung, Lubert Stryer, Stephen P.A. Fodor, J. Leighton Read