Patents by Inventor Michael C. Schmitz
Michael C. Schmitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11744938Abstract: Titration schemes are carried out by medical infusion devices, such as ambulatory or implantable infusion devices. The titration schemes carried out by infusion systems and devices may take into account patient side effects in controlling the rate at which a medicament is delivered from the devices of systems.Type: GrantFiled: August 24, 2020Date of Patent: September 5, 2023Assignee: Medtronic, Inc.Inventors: Michael C. Schmitz, Dale F. Seeley, Keith R. Hildebrand
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Publication number: 20200384194Abstract: Titration schemes are carried out by medical infusion devices, such as ambulatory or implantable infusion devices. The titration schemes carried out by infusion systems and devices may take into account patient side effects in controlling the rate at which a medicament is delivered from the devices of systems.Type: ApplicationFiled: August 24, 2020Publication date: December 10, 2020Inventors: Michael C. Schmitz, Dale F. Seeley, Keith R. Hildebrand
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Patent number: 10813900Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: GrantFiled: August 19, 2019Date of Patent: October 27, 2020Assignee: SAOL INTERNATIONAL LIMITEDInventors: Michael C. Schmitz, Corinne Dominguez, Thomas E. Keene, Deanna S. Lane, Lanchi T. Le, Jianwei Li, Ngoc T. Lu, Carmen E. Snaza
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Publication number: 20200078327Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: ApplicationFiled: August 19, 2019Publication date: March 12, 2020Applicant: SAOL INTERNATIONAL LIMITEDInventors: Michael C. SCHMITZ, Corinne DOMINGUEZ, Thomas E. KEENE, Deanna S. LANE, Lanchi T. LE, Jianwei LI, Ngoc T. LU, Carmen E. SNAZA
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Patent number: 10420740Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: GrantFiled: August 20, 2018Date of Patent: September 24, 2019Assignee: SAOL INTERNATIONAL LIMITEDInventors: Michael C. Schmitz, Corinne Dominguez, Thomas E. Keene, Deanna S. Lane, Lanchi T. Le, Jianwei Li, Ngoc T. Lu, Carmen E. Snaza
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Publication number: 20190054050Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: ApplicationFiled: August 20, 2018Publication date: February 21, 2019Inventors: Michael C. SCHMITZ, Corinne DOMINGUEZ, Thomas E. KEENE, Deanna S. LANE, Lanchi T. LE, Jianwei LI, Ngoc T. LU, Carmen E. SNAZA
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Patent number: 10076506Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: GrantFiled: February 7, 2017Date of Patent: September 18, 2018Assignee: SAOL INTERNATIONAL LIMITEDInventors: Michael C. Schmitz, Corinne Dominguez, Thomas E. Keene, Deanna S. Lane, Lanchi T. Le, Jianwei Li, Ngoc T. Lu, Carmen E. Snaza
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Publication number: 20170304242Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: ApplicationFiled: February 7, 2017Publication date: October 26, 2017Applicant: SAOL INTERNATIONAL LIMITEDInventors: Michael C. SCHMITZ, Corinne DOMINGUEZ, Thomas E. KEENE, Deanna S. LANE, Lanchi T. LE, Jianwei LI, Ngoc T. LU, Carmen E. SNAZA
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Patent number: 9707338Abstract: An ambulatory infusion device includes a common module having a pump mechanism and a fluid flow path in communication with the pump mechanism. The device also includes a custom module operably coupleable to the common module. The custom module includes a reservoir for housing a liquid composition comprising a medicament and control electronics. The reservoir is configured to fluidly couple with the fluid flow path, and the control electronics are configured to electrically couple to the pump mechanism when the common module and the custom module are operably coupled. When the common module and the custom module are operably coupled, the pump mechanism is configured to drive the liquid composition from the reservoir to a patient via the fluid flow path, and the control electronics are configured to control the rate at which the pump mechanism drives the liquid composition.Type: GrantFiled: October 25, 2013Date of Patent: July 18, 2017Assignee: MEDTRONIC, INC.Inventors: Dale F. Seeley, Michael C. Schmitz, Keith R. Hildebrand, Edwin Rivera
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Patent number: 9597304Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: GrantFiled: November 6, 2015Date of Patent: March 21, 2017Assignee: SAOL INTERNATIONAL LIMITEDInventors: Michael C. Schmitz, Corinne Dominguez, Thomas E. Keene, Deanna S. Lane, Lanchi T. Le, Jianwei Li, Ngoc T. Lu, Carmen E. Snaza
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Patent number: 9463889Abstract: Prefilled reservoir apparatuses for use in ambulatory infusion devices include a rigid top and a flexible bag that forms at least a portion of a reservoir containing a liquid medicament composition. The reservoir apparatuses include a septum assembly that includes a fluid flow path in communication with the reservoir and a self-sealing septum disposed in or over the fluid flow path. The septum is positioned and configured to be pierced by a cannula of a base of an infusion device when the reservoir apparatus is received by the base.Type: GrantFiled: October 25, 2013Date of Patent: October 11, 2016Assignee: Medtronic, Inc.Inventors: Michael C. Schmitz, Dale F. Seeley, Keith R. Hildebrand
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Publication number: 20160058724Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: ApplicationFiled: November 6, 2015Publication date: March 3, 2016Inventors: Michael C. Schmitz, Corinne Dominguez, Thomas E. Keene, Deanna S. Lane, Lanchi T. Le, Jianwei Li, Ngoc T. Lu, Carmen E. Snaza
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Patent number: 9180108Abstract: Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.Type: GrantFiled: October 26, 2012Date of Patent: November 10, 2015Assignee: Medtronic, Inc.Inventors: Michael C. Schmitz, Corinne Dominguez, Thomas E. Keene, Deanna S. Lane, Lanchi T. Le, Jianwei Li, Ngoc T. Lu, Carmen E. Snaza
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Patent number: 9155695Abstract: Compositions and methods are provided that utilize an injectable ropinirole having a therapeutically effective amount of ropinirole in an aqueous solvent, the composition having a pH of from about 3.0 to about 6.5. The compositions and methods provided contain less than 3% by weight of impurities and are suitable for administration by infusion pumps. In some embodiments, the compositions are made in an oxygen free environment and/or are made with an antioxidant to reduce impurities and improve stability. In some embodiments, the compositions provided are utilized to treat Parkinson's disease.Type: GrantFiled: March 14, 2013Date of Patent: October 13, 2015Assignee: Medtronic, Inc.Inventors: Michael C. Schmitz, Roger E. Harrington, Carmen E. Snaza, Keith R. Hildebrand, Ngoc N. Lu
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Publication number: 20150119804Abstract: An ambulatory infusion device includes a common module having a pump mechanism and a fluid flow path in communication with the pump mechanism. The device also includes a custom module operably coupleable to the common module. The custom module includes a reservoir for housing a liquid composition comprising a medicament and control electronics. The reservoir is configured to fluidly couple with the fluid flow path, and the control electronics are configured to electrically couple to the pump mechanism when the common module and the custom module are operably coupled. When the common module and the custom module are operably coupled, the pump mechanism is configured to drive the liquid composition from the reservoir to a patient via the fluid flow path, and the control electronics are configured to control the rate at which the pump mechanism drives the liquid composition.Type: ApplicationFiled: October 25, 2013Publication date: April 30, 2015Applicant: MEDTRONIC, INC.Inventors: Dale F. Seeley, Michael C. Schmitz, Keith R. Hildebrand, Edwin Rivera
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Publication number: 20150119821Abstract: Prefilled reservoir apparatuses for use in ambulatory infusion devices include a rigid top and a flexible bag that forms at least a portion of a reservoir containing a liquid medicament composition. The reservoir apparatuses include a septum assembly that includes a fluid flow path in communication with the reservoir and a self-sealing septum disposed in or over the fluid flow path. The septum is positioned and configured to be pierced by a cannula of a base of an infusion device when the reservoir apparatus is received by the base.Type: ApplicationFiled: October 25, 2013Publication date: April 30, 2015Applicant: MEDTRONIC, INC.Inventors: Michael C. Schmitz, Dale F. Seeley, Keith R. Hildebrand
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Publication number: 20150032053Abstract: Titration schemes are carried out by medical infusion devices, such as ambulatory or implantable infusion devices. The titration schemes carried out by infusion systems and devices may take into account patient side effects in controlling the rate at which a medicament is delivered from the devices of systems.Type: ApplicationFiled: July 29, 2013Publication date: January 29, 2015Applicant: MEDTRONIC, INC.Inventors: Michael C. Schmitz, Dale F. Seeley, Keith R. Hildebrand
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Publication number: 20140275202Abstract: Compositions and methods are provided that utilize an injectable ropinirole having a therapeutically effective amount of ropinirole in an aqueous solvent, the composition having a pH of from about 3.0 to about 6.5. The compositions and methods provided contain less than 3% by weight of impurities and are suitable for administration by infusion pumps. In some embodiments, the compositions are made in an oxygen free environment and/or are made with an antioxidant to reduce impurities and improve stability. In some embodiments, the compositions provided are utilized to treat Parkinson's disease.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Applicant: Medtronic, Inc.Inventors: Michael C. Schmitz, Roger E. Harrington, Carmen E. Snaza, Keith R. Hildebrand, Ngoc N. Lu