Patents by Inventor Michael C. Van Zandt
Michael C. Van Zandt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7498356Abstract: Disclosed are compound and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compound of the invention include inhibitors of protein tyrosine phosphatase, in particular protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising aforementioned conditions using such compounds.Type: GrantFiled: November 18, 2005Date of Patent: March 3, 2009Assignee: The Institutes for Pharmaceutical Discovery LLCInventors: Darren Whitehouse, Shaojing Hu, Michael C. Van Zandt, Garrett Parker
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Patent number: 7465825Abstract: Disclosed are compounds and pharmaceutically acceptable salts of formula (A): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.Type: GrantFiled: November 18, 2005Date of Patent: December 16, 2008Assignee: The Institute for Pharmaceutical Discovery, LLCInventors: Michael C. Van Zandt, Haiquan Fang, Shaojing Hu, Darren Whitehouse
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Publication number: 20080214540Abstract: Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.Type: ApplicationFiled: December 4, 2007Publication date: September 4, 2008Inventors: Michael Lee Jones, David Gunn, John Howard Jones, Michael C. Van Zandt
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Publication number: 20080146574Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.Type: ApplicationFiled: February 12, 2008Publication date: June 19, 2008Inventors: Darren Whitehouse, Shaojing Hu, Haiquan Fang, Kerry Combs, Michael C. Van Zandt
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Patent number: 7361671Abstract: Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)R?, where D, A, and R? are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.Type: GrantFiled: November 14, 2002Date of Patent: April 22, 2008Assignee: The Institute for Pharmaceutical Discovery, Inc.Inventors: Michael C. Van Zandt, Leo Geraci
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Patent number: 7358248Abstract: Disclosed are compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.Type: GrantFiled: April 30, 2004Date of Patent: April 15, 2008Assignee: The Institute for Pharmaceutical Discovery LLCInventors: Darren Whitehouse, Shaojing Hu, Michael C. Van Zandt, Garrett Parker, Thomas G. Meskill
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Patent number: 7358364Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.Type: GrantFiled: April 14, 2004Date of Patent: April 15, 2008Assignee: The Institute for Pharmaceutical Discovery LLCInventors: Michael C. Van Zandt, Darren Whitehouse, Kerry Combs, Shaojing Hu
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Patent number: 7329680Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.Type: GrantFiled: April 30, 2004Date of Patent: February 12, 2008Assignee: The Institute for Pharmaceutical Discovery, LLCInventors: Darren Whitehouse, Shaojing Hu, Haiquan Fang, Kerry Combs, Michael C. Van Zandt
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Patent number: 7189749Abstract: Disclosed are substituted phenoxyacetic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds, alone or in combination with other therapeutic agents, and methods of treatment employing the compounds and pharmaceutical compositions, as well as methods for their synthesis.Type: GrantFiled: September 12, 2003Date of Patent: March 13, 2007Assignee: The Institutes for Pharmaceutical Discovery LLCInventor: Michael C. Van Zandt
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Patent number: 7105514Abstract: Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.Type: GrantFiled: April 27, 2004Date of Patent: September 12, 2006Assignee: The Institute for Dibetes Discovery LLCInventors: Michael Lee Jones, David Gunn, John Howard Jones, Michael C. Van Zandt
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Publication number: 20040266788Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): 1Type: ApplicationFiled: April 14, 2004Publication date: December 30, 2004Applicant: The Institute for Pharmaceutical Discovery LLCInventors: Michael C. Van Zandt, Darren Whitehouse, Kerry Combs, Shaojing Hu
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Publication number: 20040266789Abstract: Disclosed are compounds and pharmaceutically acceptable salts of formula (I): 1Type: ApplicationFiled: April 30, 2004Publication date: December 30, 2004Inventors: Darren Whitehouse, Shaojing Hu, Michael C. Van Zandt, Garrett Parker, Thomas G. Meskill
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Publication number: 20040248937Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): 1Type: ApplicationFiled: April 14, 2004Publication date: December 9, 2004Applicant: The Institute for Pharmaceutical Discovery LLCInventors: Michael C. Van Zandt, Haiguan Fang, Shaojing Hu, Darren Whitehouse
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Publication number: 20040235933Abstract: Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.Type: ApplicationFiled: April 27, 2004Publication date: November 25, 2004Applicant: The Institute for Pharmaceutical Discovery LLCInventors: Michael Lee Jones, David Gunn, John Howar Jones, Michael C. Van Zandt
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Patent number: 6730794Abstract: Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.Type: GrantFiled: June 28, 2002Date of Patent: May 4, 2004Assignee: The Institute for Pharmaceutical Discovery, LLC.Inventors: Michael Lee Jones, David Gunn, John Howard Jones, Michael C. Van Zandt
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Publication number: 20030171405Abstract: Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in need of such treatment. Also disclosed are such compounds useful in the treatment of angiogenesis, hyperglycemia, hyperlipidemia and chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds. Further, disclosed are combinations of an angiotensin converting enzyme inhibitor and a substituted indole acetic acid.Type: ApplicationFiled: February 18, 2003Publication date: September 11, 2003Applicant: The Institutes for Pharmaceutical Discovery LLC., A Corporation of the State of DelawareInventors: Janet Sredy, Michael C. Van Zandt
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Publication number: 20030166668Abstract: Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)R′, where D, A, and R′ are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.Type: ApplicationFiled: November 14, 2002Publication date: September 4, 2003Applicant: The Institutes for Pharmaceutical Discovery, Inc. A Corporation of the State of DelawareInventors: Michael C. Van Zandt, Leo Geraci
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Publication number: 20030036558Abstract: Disclosed are substituted phenoxyacetic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds, alone or in combination with other therapeutic agents, and methods of treatment employing the compounds and pharmaceutical compositions, as well as methods for their synthesis.Type: ApplicationFiled: July 16, 2002Publication date: February 20, 2003Applicant: The Institutes of Pharmaceutical Discovery LLC.Inventor: Michael C. Van Zandt
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Patent number: 6521659Abstract: Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in need of such treatment. Also disclosed are such compounds useful in the treatment of angiogenesis, hyperglycemia, hyperlipidemia and chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds. Further, disclosed are combinations of an angiotensin converting enzyme inhibitor and a substituted indole acetic acid.Type: GrantFiled: February 28, 2001Date of Patent: February 18, 2003Assignee: Institute for Pharmaceutical Discovery, LLCInventors: Janet Sredy, Michael C. Van Zandt
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Patent number: 6426344Abstract: Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.Type: GrantFiled: March 27, 2001Date of Patent: July 30, 2002Assignee: The Institutes for Pharmaceutical Discovery LLCInventors: Michael Lee Jones, David Gunn, John Howard Jones, Michael C. Van Zandt