Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Abstract: An electrically operated valve controls the flow of oil to and from a device that activates and deactivates a cylinder of a multi-cylinder engine. A first valve seat is between an inlet and a workport connected to the device and a second valve seat is between the workport and an outlet. A valve element engages the first valve seat when a solenoid actuator is energized. The valve element and the first valve seat cooperate to allow air to bleed from the inlet through the valve upon starting the engine, but prevent the oil from flowing in that path unless the solenoid actuator is energized. In one version of the valve, the valve element engages the second valve seat when disengaged from the first valve seat. In a second version, another valve element engages the second valve seat when oil flows through the first valve seat.

Abstract: A portable medical analyzer comprising a sampling module with a sample port for receiving body fluid, an assay sensor module for analysis of the body fluid, an analytical detector module with detection of information from the assay, and a communications module for transferring the information to a remote location via a wired or wireless network.

Abstract: A process is provided that produces polyolefins.

Abstract: A method and apparatus are provided for obtaining audio information through the Internet by agents of an automatic call distributor situated at a plurality of remotely located terminals. The method includes the steps of transmitting a sign-on request from a first terminal of the plurality of remotely located terminals to a server of the automatic call distributor through the Internet notifying the server that an associated agent of the first terminal is ready for receiving calls, retrieving a universal resource locator of a web file server containing the audio information needed by the associated agent of the first terminal, said web file server being located on a second terminal of the plurality of remotely located terminals and downloading the audio information through the Internet from the web file server specified by the universal resource locator to the first terminal.

Abstract: A grip cover is provided for fitting over the hand grip of a coating dispensing device for dispensing coating material. The grip cover includes material for cushioning a hand of an operator using the coating dispensing device.

Abstract: A flexible detection/test tape includes a first flexible conductive layer, and a second flexible conductive layer positioned opposite the first conductive layer. A plurality of at least one of sensors, actuators or transducers are positioned between and are bonded to the first flexible conductive layer and the second flexible conductive layer. An insulative material is inserted around the plurality of at least one of the sensors, actuators or transducers. An electrical contact network connects to the first flexible conductive layer and the second flexible conductive layer, whereby power and control signals are provided to the flexible detection/test tape.

Abstract: A system and method for providing antialiasing of a graphical image on a display is disclosed. The graphical image is generated from data describing at least one object. The display includes a plurality of pixels. The at least one object includes a plurality of fragments. A portion of the plurality of fragments intersects a pixel of the plurality of pixels. Each of the plurality of fragments including an indication of a portion of a corresponding pixel that is intersected. The system and method include providing at least one active region for the pixel. The at least one active region intersects a first portion of the pixel. The method and system also include providing at least one new region. A first portion of the at least one new region indicates where in the pixel the at least one active region and the fragment intersect. A second portion of the at least one new region indicates where in the pixel the at least one active region and the fragment do not intersect.

Abstract: A software and hardware system and an associated methodology provides ATE-independent go/no-go testing as well as advanced failure diagnosis of integrated circuits for silicon debug, process characterization, production (volume) testing, and system diagnosis comprises an embedded test architecture designed within an integrated circuit; means for seamlessly transferring information between the integrated circuit and its external environment; and an external environment that effectuates the seamless transfer for the user to perform relevant test and diagnosis.

Abstract: A method of playing a game on a gaming machine is performed by placing a wager on an underlying wagering game and playing the underlying wagering game according to the rules of the underlying game. When a predetermined event occurs in the underlying game, the player enters at least one bonus game. The bonus game may have at least one event where a) an animated event proceeds to a conclusion and an original bonus that increments or decrements with the proceeding of that animated event, and b) using a sequential set of displays to determine a number of spins to be used in a bonus round and to determine a multiplication factor to be used in spins to be used in the bonus round.

Abstract: The present invention provides an expanded polypropylene over-mold blade sun visor carrier assembly incorporating an electrical distribution system therein in cooperative combination with a center support assembly containing a corresponding electrical distribution system and a support shaft.

Abstract: 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of the formula I or a pharmaceutically acceptable salt thereof can be used in the treatment of gastrointestinal stromal tumours.

Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

Abstract: The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase type 4.

Abstract: A system and method for mediating a web page at an intermediate server. The system and method can include receiving a web page from a target web server, ensuring that the web page is not cached and changing links in the web page to refer to the intermediate server.

Abstract: According to one embodiment, a search engine device (100) may include an input (102), search portion (106), and a vote portion (108). A vote portion (108) may receive responses to a search request at inputs. According to precedence information in received responses, a vote portion (108) may generate an output response having its own precedence information.

Abstract: Disclosed are systems and methods that include a flow-cell that includes porous conductive material(s) that provides a working electrode(s), an inlet connected to the flow-cell to deliver a solution continuing an analyte(s), an outlet connected to the flow-cell to allow the solution to exit the flow-cell, a counter electrode positioned proximate to the outlet, and a voltage source(s) coupled to the working electrode(s) and the counter electrode. The methods can include delivering a solution containing an analyte(s) through an inlet to a flow-cell that includes porous conductive material(s) that provides a working electrode(s), connecting the flow-cell to an outlet for allowing the solution to exit the flow-cell, placing a counter-electrode proximate the outlet, and supplying a voltage from a voltage source(s) to the working electrode(s) and/or the counter-electrode.

Abstract: A chromatic-dispersion compensator comprises a plurality of dispersive elements (Q in number. Q?2) each exhibiting a dispersion characteristic D (?) that varies substantially as a polynominal function of wavelength, the polynomial function being of an order (P?2) greater than 0, the dispersion characteristics being displaced in wavelength relative to each other such that the compensator has a net Pth-order dispersion characteristic Dp that is non-zero and does not vary substantially with wavelength an operating bandwidth.