Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: The present invention relates to an aqueous based, solvent free degreaser composition, comprising a blend of two nonionic surfactants selected from, alcohol alkoxylate with a fatty alcohol moiety, alkoxylated fatty alcohol, fatty alcohol having oxyethylate moieties, polyoxyalkylene block copolymers, and alkyl phenol alkoxylate.

Abstract: The present invention relates to an aqueous based, solvent free degreaser composition, comprising a blend of two nonionic surfactants selected from, alcohol alkoxylate with a fatty alcohol moiety, fatty alcohol, fatty alcohol having oxyethylate moieties, polyoxyalkylene block copolymers, and alkyl phenol alkoxylate.

Abstract: Solid automatic dishwasher detergent tablets have a chlorine source to most preferably provide 0.5 to 5 percent available chlorine; and a chlorine stability enhancing effective amount of preferably between about 0.5 to about 10 percent by weight of one or more nonionic surfactants having the following structure: R—(AO1)x(AO2)y—OR′ wherein: R is a C6-C18 alkyl group, AO1 represents propylene oxide or a mixture of propylene oxide and other alkylene oxides, AO2 represents ethylene oxide or a mixture of ethylene oxide and other alkylene oxides, R′ is an alkyl, arylalkyl, or benzalkyl group with 1 to about 10 carbon atoms, x is 2-20, y is 0-20, and the sum of x plus y is 5 or greater. The nonionic surfactant imparts improved chlorine stability to the tablet such that greater than 80 percent of the chlorine in the tablet remains active for eight weeks when the tablet is stored at 120° F.

Abstract: Solid automatic dishwasher detergent tablets have a chlorine source to most preferably provide 0.5 to 5 percent available chlorine; and a chlorine stability enhancing effective amount of preferably between about 0.

Abstract: Hard surface cleaning formulations include an associative thickener and a blend of at least two nonionic surfactants selected from the group consisting of ethoxylated alcohols and ethoxylated fatty acids. The formulations exhibit an advantageously high foam volume of at least about 150 cc when a 100 ml aqueous solution containing about 0.1 wt. % of the formulation is agitated at 2,500 rpm for a cumulative agitation period of about 1200 seconds. The formulations also exhibit satisfactory foam stability sufficient to clean at least about 25 plates (ASTM D4009-92). Preferably, the associative thickener is the reaction product of a C6 or greater epoxide compound with a polyoxyalkylene polyol. The ethoxylated alcohols and ethoxylated fatty acids each most preferably contain C8 to C18 carbon chains which are ethoxylated with between about 3 to about 20 moles of ethylene oxide.

Abstract: Cleaning formulations and methods are provided by which solid deposition is inhibited on hydrophobic hard surfaces typically encountered in bathroom and outdoor environments without detrimentally affecting the appearance of such surfaces. The formulations most preferably include an aqueous mixture of an organically solvated nonionic copolymer, a polyacrylic acid homopolymer and a nonionic surfactant. Optionally, a hydrotrope may also be present in the formulation. Most preferably, the formulations of this invention have a pH between about 4.0 to about 7.0, most preferably around neutral (i.e., about 7.0).

Abstract: The present invention relates to an aqueous based, solvent free degreaser composition, comprising a blend of two nonionic surfactants selected from, alcohol alkoxylate with a fatty alcohol moiety alkoxlyate, fatty alkoxlyated alcohol, fatty alcohol having oxyethylate moieties, polyoxyalkylene block copolymers, and alkyl phenol alkoxylate.

Abstract: There is provided an aqueous hard surface cleaning composition comprising a) a water soluble organic solvent; b) a nonionic surfactant selected from the group consisting of an alcohol alkoxylate, an alcohol block alkoxylate, a polyxyethylene polyoxypropylene block surfactant, and mixtures thereof; and c) an effective amount up to about 5% by weight of a cleaning auxiliary selected from the group consisting of methylglycine diacetic acid, hydroxyethyl ethylenediamine triacetic acid, diethylenetriamine pentaacetic acid, ethylenediamine tetraacetic acid, nitilotriacetic acid, salts thereof, and mixtures thereof; and d) optionally, a thickening agent. The compositions are useful for cleaning hard surfaces with a minimum of wiping and scrubbing.

Abstract: Cleaning formulations and methods are provided by which solid deposition is inhibited on hydrophobic hard surfaces typically encountered in bathroom and outdoor environments without detrimentally affecting the appearance of such surfaces. The formulations most preferably include an aqueous mixture of an organically solvated nonionic copolymer, a polyacrylic acid homopolymer and a nonionic surfactant. Optionally, a hydrotrope may also be present in the formulation. Most preferably, the formulations of this invention have a pH between about 4.0 to about 7.0, most preferably around neutral (i.e., about 7.0).

Abstract: There is provided a hard surface cleaning composition comprising: (a) a water soluble organic solvent; (b) an anionic surfactant which comprises the reaction product of maleic acid, fumaric acid, itaconic acid, or a mixture thereof and at least one selected poly(oxyalkylated) polyol or epoxy-capped poly(oxyalkylated) polyol in the presence of a peroxy-type free radical initiator to form a carboxylic group containing addition product,; and (c) a third component comprising a chelating agent or a nonionic surfactant selected from the group consisting of alcohol alkoxylates, alcohol block alkoxylates, polyoxyethylene polyoxypropylene block surfactants, and mixtures thereof.

Abstract: Most generally, the invention provides a method for making a neutralized polyether polyol, comprising the steps of a) Polymerizing one or more alkylene oxides in the presence of an alkaline catalyst to form a polyalkylene oxide intermediate; and b) Neutralizing the intermediate, after the polymerization step a) is complete, with an organic acid of general formula where R1 is hydrogen, methyl, or ethyl; R2 is methyl or ethyl; and R3 is an alkyl, aryl, or aralkyl group containing one to twelve carbon atoms. The invention also comprises the novel compositions made by the above process.

Abstract: The present invention relates to an aqueous based, solvent free degreaser composition, comprising a blend of two nonionic surfactants selected from, alcohol alkoxylate with a fatty alcohol moiety, alkoxylated fatty alcohol, fatty alcohol having oxyethylate moieties, polyoxyalkylene block copolymers, and alkyl phenol alkoxylate.

Abstract: An improved powdered non-phosphate machine dishwashing composition comprising a blend of nonionic surfactants, builders, chlorine or non-chlorine bleach, bleach activators, enzymes and copolymers of alkylene oxides adducts of allyl alcohol and acrylic acid useful in reducing spotting and filming of dishware.

Abstract: The present invention relates to an aqueous based, solvent free degreaser composition, comprising (a) alcohol alkoxylate with a fatty alcohol moiety, (b) polyoxyalkylene block copolymer, and (c) a fatty alcohol having an oxyethylate moiety.

Abstract: The present invention relates to an aqueous based, solvent free cleaning composition, comprising polyoxyalkylene block copolymers and fatty alcohols having oxyethylate moieties.

Abstract: The present invention relates to an aqueous based, solvent free cleaning composition, comprising (a) a polyoxyalkylene block copolymer, (b) an alkyl phenol alkoxylate, and (c) fatty alcohols having oxyethylate moieties.

Abstract: The present invention relates to an aqueous based, solvent free cleaning composition, comprising a polyoxyalkylene block copolymer triblend.

Abstract: The present invention relates to an aqueous based, solvent free degreaser composition, comprising (a) alcohol alkoxylate with a fatty alcohol moiety, (b) alkoxylated fatty alcohol, and (c) a fatty alcohol having an oxyethylate moiety.

Abstract: An improved rinse aid composition comprising a blend of nonionic low foam surfactants, hydrotropes, polycarboxylate polymers and alkyliminodialkanoates.