Patents by Inventor Michael CALANDRA

Michael CALANDRA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Splicing modulator antibody-drug conjugates and methods of use
    Patent number: 11945807
    Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.
    Type: Grant
    Filed: May 3, 2022
    Date of Patent: April 2, 2024
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Ermira Pazolli, Silvia Buonamici, Thiwanka Samarakoon, Sudeep Prajapati, Nathan Fishkin, James Palacino, Michael Seiler, Ping Zhu, Andrew Cook, Peter Smith, Xiang Liu, Shelby Ellery, Dominic Reynolds, Lihua Yu, Zhenhua Wu, Shouyong Peng, Nicholas Calandra, Megan Sheehan, Yonghong Xiao
  • PREVENTION, REDUCTION, OR AMELIORATION OF OLD PERSON SMELL
    Publication number: 20230210735
    Abstract: The various aspects presented herein relate to methods and compositions for the reduction, prevention, and/or inhibition of old person smell.
    Type: Application
    Filed: June 9, 2021
    Publication date: July 6, 2023
    Applicant: Firmenich SA
    Inventors: Ying WANG, Gary WOMACK, Jana PIKA, Michael CALANDRA, Dushanee SRIYARATHNE
  • PREVENTION OF THE OXIDATION OF PERFUMERY RAW MATERIALS AND FOOD RAW MATERIALS
    Publication number: 20210395638
    Abstract: The various aspects presented herein relate to methods for the reduction, prevention and/or inhibition of the oxidation of perfume ingredients, formulated perfumes, formulated body care products, formulated skin care products, formulated homecare products, essential oils, food raw materials, formulated food products and natural extracts.
    Type: Application
    Filed: October 31, 2019
    Publication date: December 23, 2021
    Applicant: Firmenich SA
    Inventors: Michael CALANDRA, Ying WANG, Dushanee SRIYARATHNE, Gary WOMACK, Florian DE NANTEUIL, Rutger VAN SLEEUWEN, Brian MACDOUGALL, Tieu-Vey LAM, Sylvie BRETON
  • PREVENTION OF THE OXIDATION OF PERFUMERY RAW MATERIALS
    Publication number: 20200289388
    Abstract: The aspects presented herein provide methods and compositions for the reduction of the peroxide value of perfume ingredients, formulated perfumes, formulated body care products, essential oils, and natural extracts.
    Type: Application
    Filed: January 24, 2019
    Publication date: September 17, 2020
    Applicant: Firmenich SA
    Inventors: Janille Marie JUMALON, Addi FADEL, Michael CALANDRA, Ying WANG, Melanie SMITH