Patents by Inventor Michael Capaldi

Michael Capaldi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Producing Heterodimeric Antibodies
    Publication number: 20200190200
    Abstract: The invention relates to methods of producing heterodimeric antibodies.
    Type: Application
    Filed: December 17, 2019
    Publication date: June 18, 2020
    Inventors: Pedro Jose Alfonso Martin, Michael Capaldi, Jeffrey Cohen, Andrew Detzel, Joseph Sakyiama
  • Process for preparing unaggregated antibody Fc domains
    Patent number: 8853371
    Abstract: Methods useful for producing a solution of purified Fc peptide chains are disclosed. The methods employ protein A chromatography to separate high molecular weight, aggregated peptide chains comprising antibody Fc domains from lower molecular weight unaggregated peptide chains that also comprise antibody Fc domains. The solutions of purified Fc peptide chains obtained by the methods of the invention contain less than 5% aggregate and greater than 70% of the Fc peptide chains subjected to purification.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: October 7, 2014
    Assignee: Janssen Biotech, Inc.
    Inventors: Pedro Alfonso, Michael Capaldi, Dennis Dong, Thomas R. Gervais, Joshua Goldstein, Allen B. Magill, Nicole Quinlan, Deepak Saini
  • Process for Preparing Unaggregated Antibody FC Domains
    Publication number: 20090171072
    Abstract: Methods useful for producing a solution of purified Fc peptide chains are disclosed. The methods employ protein A chromatography to separate high molecular weight, aggregated peptide chains comprising antibody Fc domains from lower molecular weight unaggregated peptide chains that also comprise antibody Fc domains. The solutions of purified Fc peptide chains obtained by the methods of the invention contain less than 5% aggregate and greater than 70% of the Fc peptide chains subjected to purification.
    Type: Application
    Filed: October 19, 2007
    Publication date: July 2, 2009
    Inventors: Pedro Alfonso, Michael Capaldi, Dennis Dong, Thomas R. Gervais, Joshua Goldstein, Allen B. Magill, Nicole Quinlan, Deepak Saini