Abstract: Provided herein are methods and corresponding compounds for treating fibrotic disease by administering to a subject a compound of Formula I or pharmaceutically acceptable salt thereof, which inhibits phosphorylation of Smad2/3, according to Phospho-Smad2/3 Inhibition Assay, including compounds that are active according to MAPK p38 Activation Assay; or a compound of Formula II or III. Also provided are methods and corresponding compounds for treating cancers, inflammatory diseases, rasopathies and autoimmune leukoproliferative disorders.

Abstract: (A blade (12) for a trowel (10) comprises a rectangular front face for spreading material and a rear face adapted to be attached to a handle (14). A plurality of sequentially smaller rectangular lamellae (16, 18, 20, 22) are bonded together in a stack to create a progression of steps in the face of the blade. As the blade (12) is used to apply, for example, plaster to a wall, the surfaces of the lamellae adjacent the steps act as edges, which spread and smooth the plaster. An alternative embodiment comprising three parallel ribs mounted on a lamina (102) is shown in FIG. 8.