Patents by Inventor Michael Casutt

Michael Casutt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of a D-(+)-biotin intermediate
    Patent number: 5847152
    Abstract: The present invention relates to an improved process for making heterocyclic compounds suitable for intermediate products for making D-(+)-biotin and a process for making D-(+)-biotin itself.
    Type: Grant
    Filed: September 26, 1996
    Date of Patent: December 8, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Jurgen Eckstein, Thomas Koppe, Michael Schwarz, Michael Casutt
  • Triazine derivatives with UV filter properties
    Patent number: 5520906
    Abstract: Triazine compounds of the formula I ##STR1## wherein Y is NH or O,R.sup.1 in each case independently of one another are a radical of the formula II ##STR2## wherein Phe is a phenylene group which is unsubstituted or substituted by 1 to 4 alkyl or alkoxy groups having 1 to 10 C atoms andX is H or --SO.sub.3 H,andR.sup.2 and R.sup.3in each case independently of one another are a radical of the formula Y-R.sup.1,oralkoxy, alkylamino, arylamino or aryloxy having 1 to 10 C atoms. Also, cosmetic formulations, medicaments and pharmaceutical formulations containing the compounds, particularly as filters for solar rays.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: May 28, 1996
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Ingeborg Stein, Michael Casutt, Ulrich Heywang, Roland Martin, Michael Schwarz
  • Process for preparing 2-arylbenzimidazole-5-sulfonic acids
    Patent number: 5473079
    Abstract: The invention relates to an improved process for preparing 2-arylbenzimidazole-5-sulfonic acids of the formula I, ##STR1## in which Ar is unsubstituted phenyl or phenyl substituted by one or more C.sub.1 -C.sub.6 alkyl or alkoxy groups andm is 1, 2 or 3,wherein o-phenylenediamine is reacted in the presence of sulfuric acid at between room temperature and 250.degree. C. with a benzoic acid derivative of the formula IIAr(--X).sub.
    Type: Grant
    Filed: October 1, 1993
    Date of Patent: December 5, 1995
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Ulrich Heywang, Ingeborg Stein, Ulrich Fechtel, Michael Casutt, Gerald Faller, Hartmut Hartner
  • Benzylidenequinuclidinones
    Patent number: 5399563
    Abstract: The invention relates to benzylidene-quinuclidinone derivatives of the formula I ##STR1## in which R.sup.1 is A;R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are in each case independently of one another H, A, OA or OH; andA is a straight-chain or branched alkyl radical having 1 to 10 C atomsand processes for their preparation and their use in cosmetic and/or pharmaceutical preparations.
    Type: Grant
    Filed: July 1, 1993
    Date of Patent: March 21, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Ingeborg Stein, Roland Martin, Michael Casutt, Ulrich Heywang, Henning Bottcher, Gunther Holzemann
  • Process for the preparation of N-protected dialkyl (2S,3S)-3-ethylaspartates
    Patent number: 5275941
    Abstract: The invention relates to a process for the preparation of N-protected dialkyl (2S,3S)-3-ethylaspartates or their salts from unpurified (2S,3S)-3-ethylaspartic acid obtainable by enzymatic amination of ethylfumaric acid.
    Type: Grant
    Filed: November 6, 1991
    Date of Patent: January 4, 1994
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Ulrich Heywang, Harry Schwartz, Michael Casutt
  • 2-oxo-5-mercaptomethylimidazolidine-4-ols
    Patent number: 5250699
    Abstract: The invention relates to a process for the preparation of D-(+)-biotin, from a cysteine hydantoin of the formula I ##STR1## in which R.sup.1 is H, or a group R.sup.3 R.sup.4 CH-- or SiR.sup.5 R.sup.6 R.sup.7, in whichR.sup.3 and R.sup.4 in each case independently of one another are H, unsubstituted or substituted alkyl, cycloalkyl, aryl, aralkyl or heteroaryl or, taken together, are unsubstituted or substituted alkylene or heteroalkylene,R.sup.5, R.sup.6 and R.sup.7 in each case independently of one another are unsubstituted or substituted alkyl, cycloalkyl, aryl, aralkyl or heteroaryl,R.sup.2 is H or a protective group suitable for a nitrogen atom andX is O, S or N--R.sup.8, in whichR.sup.8 is an alkyl, cycloalkyl, aryl or alkoxycarbonyl group or a dialkylamino group and to intermediates which are passed through in this process.
    Type: Grant
    Filed: April 10, 1991
    Date of Patent: October 5, 1993
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Michael Casutt, Eike Poetsch, Willem N. Speckamp
  • Process for the preparation of a D-(+)-biotin intermediate
    Patent number: 5235065
    Abstract: The present invention relates to a process for the preparation of heterocyclic compounds which are suitable as intermediates for the preparation of D-(+)-biotin, and to a process for the preparation of D-(+)-biotin itself. The invention further relates to intermediates in this process.
    Type: Grant
    Filed: March 5, 1992
    Date of Patent: August 10, 1993
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Michael Schwarz, Michael Casutt, Jurgen Eckstein
  • Process for the preparation of imidazothiazolone derivatives
    Patent number: 5233045
    Abstract: The invention relates to a novel process for the preparation of imidazothiazolone derivatives of formula I, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in the claims, which are suitable for the preparation of D-(+)-biotin.
    Type: Grant
    Filed: May 15, 1992
    Date of Patent: August 3, 1993
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Michael Schwarz, Michael Casutt
  • Pilosinine derivatives
    Patent number: 5180837
    Abstract: The invention relates to a process for the preparation of racemic pilosinine derivatives as precursor for the alkaloid pilocarpine of pharmacological importance from a 5-formyl-1-alkylimidazole of the formula I ##STR1## in which R.sup.1 is a straight-chain or branched alkyl chain with 1-6 C atoms which, via the stage of the thioacetal, is added onto .gamma.-crotonolactone.
    Type: Grant
    Filed: October 23, 1991
    Date of Patent: January 19, 1993
    Assignee: Merck Patent Gesellschaft mit beschraenkter Haftung
    Inventors: Ulrich Heywang, Michael Casutt, Michael Schwarz
  • Process for the preparation of D-(+)-biotin
    Patent number: 5095118
    Abstract: D-(+)-biotin can be prepared from optically active hydantoins of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given in Patent claim 1, in a simple, stereospecific manner. Furthermore bicyclic nitriles of the formula XI ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given represent precious intermediate products and educts of a multitude of possibilities to synthesize optically active D-(+)-biotin.
    Type: Grant
    Filed: April 13, 1990
    Date of Patent: March 10, 1992
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Eike Poetsch, Michael Casutt
  • Process for the preparation of 5-membered nitrogen containing heteroaromatics
    Patent number: 5075452
    Abstract: Compounds of the formula I ##STR1## in which A and X.sup.1 have the meaning given in patent claim 1 can be prepared in a simple manner, in a one-pot process and in high yields.
    Type: Grant
    Filed: December 6, 1989
    Date of Patent: December 24, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Richard Kirchlechner, Michael Casutt, Arno Basedow
  • Optically active hydantoins
    Patent number: 5068341
    Abstract: Optically active hydantoins of the formula I ##STR1## wherein X, Y, R.sup.1, R.sup.2 and R.sup.3 have the meaning given in Patent claim 1, are useful intermediate products for the preparation of D-(+)-biotin.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: November 26, 1991
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Eike Poetsch, Michael Casutt
  • Process for the preparation of D-(+)-biotin
    Patent number: 4937351
    Abstract: D-(+)-biotin can be prepared from optically active hydantoins of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given in Patent Claim 1, in a simple, sterospecific manner.Furthermore bicyclic nitriles of the formula XI ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given represent precious intermediate products and educts of a multitude of possibilities to synthesize optically active D-(+)-biotin.
    Type: Grant
    Filed: October 17, 1989
    Date of Patent: June 26, 1990
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Eike Poetsch, Michael Casutt
  • Process for the preparation of D-(+)-biotin
    Patent number: 4877882
    Abstract: D-(+)-Biotin can be prepared from optically active hydantoins of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given in patent claim 1, in a simple, stereospecific manner.Furthermore bicyclic nitriles of the formula XI ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given represent precious intermediate products and educts of a multitude of possibilities to synthesize optically active D-(+)-biotin.
    Type: Grant
    Filed: October 5, 1988
    Date of Patent: October 31, 1989
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Eike Poetsch, Michael Casutt
  • Process for the preparation of D-(+)-biotin
    Patent number: 4837402
    Abstract: D-(+)-Biotin can be prepared from optically active hydantoins of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given in patent claim 1, in a simple, stereospecific manner.Furthermore bicyclic nitriles of the formula XI ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given represent precious intermediate products and educts of a multitude of possibilities to synthesize optically active D-(+)-biotin.
    Type: Grant
    Filed: January 6, 1988
    Date of Patent: June 6, 1989
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Eike Poetsch, Michael Casutt
  • Process for the preparation of enantiomers
    Patent number: 4739071
    Abstract: Enantiomers of optically active dicarboxylic acid monoesters are obtained by subjecting them to intramolecular rearrangement involving reversal of the direction of rotation.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: April 19, 1988
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Michael Casutt, Eike Poetsch
  • Process for the preparation of D-(+)-biotin
    Patent number: 4732987
    Abstract: D-(+)-Biotin can be prepared from optically active hydantoins of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given in patent claim 1, in a simple, stereospecific manner.Furthermore bicyclic nitriles of the formula XI ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given represent precious intermediate products and educts of a multitude of possibilities to synthesize optically active D-(+)-biotin.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: March 22, 1988
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Eike Poetsch, Michael Casutt