Patents by Inventor Michael Centola

Michael Centola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220381795
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Application
    Filed: March 4, 2022
    Publication date: December 1, 2022
    Applicants: Laboratory Corporation of America Holdings, Oklahoma Medical Research Foundation
    Inventors: Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Publication number: 20220184169
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Application
    Filed: March 2, 2022
    Publication date: June 16, 2022
    Inventors: Tomy Yesudas, Philip Alex, Michael Centola, Adam Joshua Payne
  • Patent number: 11300575
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: April 12, 2022
    Assignees: Laboratory Corporation of America Holdings, Oklahoma Medical Research Foundation
    Inventors: Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Patent number: 10968260
    Abstract: Disclosed here are compositions comprising a curcuminoid-peptide complex. Also disclosed are methods of preparing a curcuminoid-peptide complex, comprising obtaining a curcuminoid; obtaining a peptide; and mixing the curcuminoid and the peptide in a solvent. Also disclosed are methods of treating a subject, the method comprising identifying a subject in need of treatment of a curcumin-related disorder, and administering to the subject a therapeutic composition comprising a curcuminoid-peptide complex as described. Also disclosed are therapeutic compositions comprising a curcuminoid-peptide complex as described and a pharmaceutically acceptable excipient, diluent, or carrier.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: April 6, 2021
    Assignees: HAUS BIOCEUTICALS, INC., RIXOMA, INC.
    Inventors: Adam J. Payne, Michael Centola, John Chancey
  • Publication number: 20200400682
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Application
    Filed: November 12, 2019
    Publication date: December 24, 2020
    Inventors: Pankaj Oberoi, Steven C. Hoffmann, Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Publication number: 20200399331
    Abstract: Disclosed here are compositions comprising a curcuminoid-peptide complex. Also disclosed are methods of preparing a curcuminoid-peptide complex, comprising obtaining a curcuminoid; obtaining a peptide; and mixing the curcuminoid and the peptide in a solvent. Also disclosed are methods of treating a subject, the method comprising identifying a subject in need of treatment of a curcumin-related disorder, and administering to the subject a therapeutic composition comprising a curcuminoid-peptide complex as described. Also disclosed are therapeutic compositions comprising a curcuminoid-peptide complex as described and a pharmaceutically acceptable excipient, diluent, or carrier.
    Type: Application
    Filed: September 1, 2020
    Publication date: December 24, 2020
    Applicants: Haus Bioceuticals, Inc.
    Inventors: Adam J. PAYNE, Michael CENTOLA, John CHANCEY
  • Publication number: 20200368308
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Application
    Filed: April 7, 2020
    Publication date: November 26, 2020
    Applicant: HAUS BIOCEUTICALS, INC.
    Inventors: Tomy YESUDAS, Philip ALEX, Michael CENTOLA, Adam Joshua PAYNE
  • Publication number: 20180161387
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Application
    Filed: February 6, 2018
    Publication date: June 14, 2018
    Applicant: HAUS BIOCEUTICALS, INC.
    Inventors: Tomy YESUDAS, Philip ALEX, Michael CENTOLA, Adam Joshua PAYNE
  • Patent number: 9889174
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: February 13, 2018
    Assignee: Haus Bioceuticals, Inc.
    Inventors: Tomy Yesudas, Philip Alex, Michael Centola, Adam Joshua Payne
  • Publication number: 20170168070
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Application
    Filed: December 22, 2016
    Publication date: June 15, 2017
    Inventors: Pankaj Oberoi, Steven C. Hoffmann, Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Publication number: 20170074878
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Application
    Filed: November 29, 2016
    Publication date: March 16, 2017
    Inventors: Pankaj Oberoi, Steven C. Hoffmann, Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Publication number: 20150377909
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Application
    Filed: August 21, 2015
    Publication date: December 31, 2015
    Inventors: Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Patent number: 9200324
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: December 1, 2015
    Assignees: CRESCENDO BIOSCIENCE, OKLAHOMA MEDICAL RESEARCH FOUNDATION
    Inventors: Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Publication number: 20150320878
    Abstract: Disclosed here are compositions comprising a curcuminoid-peptide complex. Also disclosed are methods of preparing a curcuminoid-peptide complex, comprising obtaining a curcuminoid; obtaining a peptide; and mixing the curcuminoid and the peptide in a solvent. Also disclosed are methods of treating a subject, the method comprising identifying a subject in need of treatment of a curcumin-related disorder, and administering to the subject a therapeutic composition comprising a curcuminoid-peptide complex as described. Also disclosed are therapeutic compositions comprising a curcuminoid-peptide complex as described and a pharmaceutically acceptable excipient, diluent, or carrier.
    Type: Application
    Filed: May 12, 2015
    Publication date: November 12, 2015
    Inventors: Adam J. PAYNE, Michael CENTOLA, John CHANCEY
  • Publication number: 20150265668
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Application
    Filed: June 8, 2015
    Publication date: September 24, 2015
    Inventors: Tomy YESUDAS, Philip ALEX, Michael CENTOLA, Adam Joshua PAYNE
  • Patent number: 9050359
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: June 9, 2015
    Assignee: Haus Bioceuticals Inc.
    Inventors: Tomy Yesudas, Philip Alex, Michael Centola, Adam Joshua Payne
  • Publication number: 20140303902
    Abstract: The present invention relates to a system and a medium for analyzing one or more analytes in rheumatoid arthritis subjects to determine whether the subject is at increased risk of diseases such as a cardiovascular disease, the subject's current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in the subject. In addition, the present invention further provides methods for analyzing data to determine risk of cardiovascular disease, current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in a rheumatoid arthritis subject.
    Type: Application
    Filed: June 26, 2014
    Publication date: October 9, 2014
    Inventors: Petar Alaupovic, Michael Centola, Joan Bathon, Jon Giles, Nicholas Knowlton, Adam Joshua Payne
  • Publication number: 20140200826
    Abstract: Quantitative datasets are created and used in the identification, monitoring and treatment of disease states and characterization of biological conditions.
    Type: Application
    Filed: March 27, 2014
    Publication date: July 17, 2014
    Applicant: Oklahoma Medical Research Foundation
    Inventors: Michael Centola, Philip J. Alex, Nicholas Knowlton, Mark Barton Frank
  • Publication number: 20140142861
    Abstract: A method scores a sample, by receiving a first dataset associated with a first sample obtained from a first subject, wherein said first dataset comprises quantitative data for at least two markers selected from the group consisting of: CCL22; CHI3L1; COMP; CRP; CSF1; CXCL10; EGF; ICAM1; ICAM3; ICTP; IL1B; IL2RA; IL6; IL6R; IL8; LEP; MMP1; MMP3; PYD; RETN; SAA1; THBD; TIMP1; TNFRSF11B; TNFRSF1A; TNFSF11; VCAM1; and VEGFA; and determining a first SDI score from said first dataset using an interpretation function, wherein the first SDI score provides a quantitative measure of the rate of change in joint structural damage in said first subject.
    Type: Application
    Filed: November 7, 2011
    Publication date: May 22, 2014
    Applicants: OKLAHOMA MEDICAL RESEARCH FOUNDATION, CRESCENDO BIOSCIENCE
    Inventors: William A. Hagstrom, David N. Chernoff, Yijing Shen, Guy L. Cavet, Michael Centola
  • Publication number: 20140128276
    Abstract: Methods, devices, and kits for diagnosing or evaluating irritable bowel syndrome employ an analysis for the presence and amount of specific cytokines. The levels of such cytokines provide an index for diagnosis and/or evaluation of therapeutic response. Samples to be tested include peripheral blood, serum, plasma, or tissue from a human subject having or suspected of having Irritable Bowel Syndrome.
    Type: Application
    Filed: January 13, 2012
    Publication date: May 8, 2014
    Applicants: OKLAHOMA MEDICAL RESEARCH FOUNDATION, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Xuhang Li, Philip Alex, Michael Centola, Nicholas Knowlton