Patents by Inventor Michael Centola

Michael Centola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12419929
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: May 9, 2024
    Date of Patent: September 23, 2025
    Assignee: Haus Bioceuticals, Inc.
    Inventors: Tomy Yesudas, Philip Alex, Michael Centola, Adam Joshua Payne
  • Publication number: 20250206788
    Abstract: Disclosed here are compositions comprising a curcuminoid-N-acetyl cysteine (NAC) complex. Also disclosed are methods of preparing a curcuminoid-N-acetyl cysteine (NAC) complex. Also disclosed are methods of treating a subject, the method comprising identifying a subject in need of treatment of a curcumin-related disorder, and administering to the subject a therapeutic composition comprising a curcuminoid-N-acetyl cysteine (NAC) complex as described. Also disclosed are therapeutic compositions comprising a curcuminoid-N-acetyl cysteine (NAC) complex as described and a pharmaceutically acceptable excipient, diluent, or carrier.
    Type: Application
    Filed: March 10, 2025
    Publication date: June 26, 2025
    Applicants: Haus Bioceuticals, Inc.
    Inventors: Adam J. PAYNE, Michael CENTOLA, John CHANCEY
  • Patent number: 12247054
    Abstract: Disclosed here are compositions comprising a curcuminoid-peptide complex. Also disclosed are methods of preparing a curcuminoid-peptide complex, comprising obtaining a curcuminoid; obtaining a peptide; and mixing the curcuminoid and the peptide in a solvent. Also disclosed are methods of treating a subject, the method comprising identifying a subject in need of treatment of a curcumin-related disorder, and administering to the subject a therapeutic composition comprising a curcuminoid-peptide complex as described. Also disclosed are therapeutic compositions comprising a curcuminoid-peptide complex as described and a pharmaceutically acceptable excipient, diluent, or carrier.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: March 11, 2025
    Inventors: Adam J. Payne, Michael Centola, John Chancey
  • Publication number: 20240350659
    Abstract: Pharmaceutical compositions, kits, and methods are disclosed for use in treating or reducing the occurrence of a viral infection in a patient. The compositions, kits, and methods utilize at least one anti-Pathogenic Host Response (anti-PHR) agent, either alone or in combination with at least one anti-viral agent.
    Type: Application
    Filed: August 19, 2022
    Publication date: October 24, 2024
    Inventors: Michael Centola, Philip ALEX
  • Publication number: 20240350660
    Abstract: Compositions and methods are disclosed for enhancing the bioavailability and/or increasing the stability of at least one agent by modifying the at least one agent with cyclodextrin. Pharmaceutical compositions including the cyclodextrin-modified agents are disclosed. Methods of manufacturing the cyclodextrin-modified agents as well as methods of using the cyclodextrin-modified agents are also disclosed.
    Type: Application
    Filed: August 19, 2022
    Publication date: October 24, 2024
    Inventors: Michael Centola, Philip ALEX
  • Publication number: 20240285721
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Application
    Filed: May 9, 2024
    Publication date: August 29, 2024
    Inventors: Tomy YESUDAS, Philip ALEX, Michael CENTOLA, Adam Joshua PAYNE
  • Publication number: 20220381795
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Application
    Filed: March 4, 2022
    Publication date: December 1, 2022
    Applicants: Laboratory Corporation of America Holdings, Oklahoma Medical Research Foundation
    Inventors: Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Publication number: 20220184169
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Application
    Filed: March 2, 2022
    Publication date: June 16, 2022
    Inventors: Tomy Yesudas, Philip Alex, Michael Centola, Adam Joshua Payne
  • Patent number: 11300575
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: April 12, 2022
    Assignees: Laboratory Corporation of America Holdings, Oklahoma Medical Research Foundation
    Inventors: Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Patent number: 10968260
    Abstract: Disclosed here are compositions comprising a curcuminoid-peptide complex. Also disclosed are methods of preparing a curcuminoid-peptide complex, comprising obtaining a curcuminoid; obtaining a peptide; and mixing the curcuminoid and the peptide in a solvent. Also disclosed are methods of treating a subject, the method comprising identifying a subject in need of treatment of a curcumin-related disorder, and administering to the subject a therapeutic composition comprising a curcuminoid-peptide complex as described. Also disclosed are therapeutic compositions comprising a curcuminoid-peptide complex as described and a pharmaceutically acceptable excipient, diluent, or carrier.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: April 6, 2021
    Assignees: HAUS BIOCEUTICALS, INC., RIXOMA, INC.
    Inventors: Adam J. Payne, Michael Centola, John Chancey
  • Publication number: 20200400682
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Application
    Filed: November 12, 2019
    Publication date: December 24, 2020
    Inventors: Pankaj Oberoi, Steven C. Hoffmann, Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Publication number: 20200399331
    Abstract: Disclosed here are compositions comprising a curcuminoid-peptide complex. Also disclosed are methods of preparing a curcuminoid-peptide complex, comprising obtaining a curcuminoid; obtaining a peptide; and mixing the curcuminoid and the peptide in a solvent. Also disclosed are methods of treating a subject, the method comprising identifying a subject in need of treatment of a curcumin-related disorder, and administering to the subject a therapeutic composition comprising a curcuminoid-peptide complex as described. Also disclosed are therapeutic compositions comprising a curcuminoid-peptide complex as described and a pharmaceutically acceptable excipient, diluent, or carrier.
    Type: Application
    Filed: September 1, 2020
    Publication date: December 24, 2020
    Applicants: Haus Bioceuticals, Inc.
    Inventors: Adam J. PAYNE, Michael CENTOLA, John CHANCEY
  • Publication number: 20200368308
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Application
    Filed: April 7, 2020
    Publication date: November 26, 2020
    Applicant: HAUS BIOCEUTICALS, INC.
    Inventors: Tomy YESUDAS, Philip ALEX, Michael CENTOLA, Adam Joshua PAYNE
  • Publication number: 20180161387
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Application
    Filed: February 6, 2018
    Publication date: June 14, 2018
    Applicant: HAUS BIOCEUTICALS, INC.
    Inventors: Tomy YESUDAS, Philip ALEX, Michael CENTOLA, Adam Joshua PAYNE
  • Patent number: 9889174
    Abstract: Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: February 13, 2018
    Assignee: Haus Bioceuticals, Inc.
    Inventors: Tomy Yesudas, Philip Alex, Michael Centola, Adam Joshua Payne
  • Publication number: 20170168070
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Application
    Filed: December 22, 2016
    Publication date: June 15, 2017
    Inventors: Pankaj Oberoi, Steven C. Hoffmann, Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Publication number: 20170074878
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Application
    Filed: November 29, 2016
    Publication date: March 16, 2017
    Inventors: Pankaj Oberoi, Steven C. Hoffmann, Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Publication number: 20150377909
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Application
    Filed: August 21, 2015
    Publication date: December 31, 2015
    Inventors: Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Patent number: 9200324
    Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: December 1, 2015
    Assignees: CRESCENDO BIOSCIENCE, OKLAHOMA MEDICAL RESEARCH FOUNDATION
    Inventors: Guy L. Cavet, Yijing Shen, Nicholas Knowlton, Michael Centola
  • Publication number: 20150320878
    Abstract: Disclosed here are compositions comprising a curcuminoid-peptide complex. Also disclosed are methods of preparing a curcuminoid-peptide complex, comprising obtaining a curcuminoid; obtaining a peptide; and mixing the curcuminoid and the peptide in a solvent. Also disclosed are methods of treating a subject, the method comprising identifying a subject in need of treatment of a curcumin-related disorder, and administering to the subject a therapeutic composition comprising a curcuminoid-peptide complex as described. Also disclosed are therapeutic compositions comprising a curcuminoid-peptide complex as described and a pharmaceutically acceptable excipient, diluent, or carrier.
    Type: Application
    Filed: May 12, 2015
    Publication date: November 12, 2015
    Inventors: Adam J. PAYNE, Michael CENTOLA, John CHANCEY