Patents by Inventor Michael CERTO

Michael CERTO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Consolidated data restoration framework
    Patent number: 11822435
    Abstract: Embodiments of the present invention provide a system for identifying occurrence of events and performing one or more actions to mitigate the impacts of the events. The system is configured for gathering data from one or more data sources of an entity, generating dataflows using the data gathered from the one or more data sources, identifying an anomaly based on one or more indicators and the dataflows, determining occurrence of an event and generating one or more propagation models associated with the event, performing event impact analysis based on the one or more propagation models, perform one or more actions to contain the event based on the one or more propagation models, identifying a last good copy of data based on the data gathered from the one or more data sources, retrieving the last good copy of data, and restoring the last good copy of data.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: November 21, 2023
    Assignee: BANK OF AMERICA CORPORATION
    Inventors: Christopher Emmanuel Huntley, Musa Ajakaiye, Prasad V. Annadata, Dnyanesh P. Ballikar, Sina Bauer, Jason Kenneth Bellew, Timothy John Bendel, David Alan Beumer, Michelle Andrea Boston, Lisa Julia Brown, Robin J. Buck, Brian C. Busch, Salvatore Michael Certo, Ramesh Naidu Chatta, Lisa Michelle Cook, Joseph Corbett, Joseph Seth Cushing, Steven Paul Davidson, Shailesh Deshpande, Sevara Ergasheva, Maria Ervin, James Wilson Foy, Jr., Noel Mary Fuller, Benjamin Judson Gaines, III, Candace Gordon, Jesse Antonio Hernandez, Christine Hoagland, Robert Charles Hoard, Michael Spiro Karafotis, Wesley Keville, Sandip Kumar, Terri Dorinda Lail, Mukesh Maraj, Wyatt Edward Maxey, Dari Ann Mckenzie, Ashley Meadows, Heather Newell, Conor Mitchell Liam Nodzak, Kenyell Javon Ollie, Jayshree G. Patel, David John Perro, Nivetha Raghavan, Nikhil Ram, Tara Michel Ramirez, Laurie Readhead, Mary Kathleen Riley, Elizabeth Rachel Rock, Angela Dawn Roose, Sanjay Singeetham, Kyle S. Sorensen, Shreyas Srinivas, Constance Jones Suarez, Viresh Taskar, Linda Trent, Sachin Varule, Bradley Walton, Christie M. Weekley, Yvette Alston, Ravindra Bandaru, Carmen R. Barnhill, Jamie Gilchrist, Namrata Kaushik, Fernando A. Maisonett
  • PCSK9 endonuclease variants, compositions, and methods of use
    Patent number: 11779654
    Abstract: The present disclosure provides improved genome editing compositions and methods for editing a PCSK9 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of hypercholesterolemia or a condition associated therewith.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: October 10, 2023
    Assignee: 2SEVENTY BIO, INC.
    Inventors: Jordan Jarjour, Kyle Havens, Michael Certo, Max Echterling
  • MULTIPARTITE SIGNALING PROTEINS AND USES THEREOF
    Publication number: 20230287111
    Abstract: The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
    Type: Application
    Filed: November 10, 2022
    Publication date: September 14, 2023
    Inventors: Jordan Jarjour, Alexander Astrakhan, Michael Certo
  • Multipartite signaling proteins and uses thereof
    Patent number: 11530265
    Abstract: The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease. As a preferred example, the present disclosure relates to fusion polypeptides comprising (a) a first polypeptide comprising a first secretion signal, a first multimerization domain, a first transmembrane domain, and an actuator domain, (b) a viral self-cleaving polypeptide, and (c) a second polypeptide comprising a second secretion signal, a binding domain that comprises a single chain antibody, a receptor ectodomain, or a ligand, a second multimerization domain, and a second transmembrane domain.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: December 20, 2022
    Assignee: 2seventy bio, Inc.
    Inventors: Jordan Jarjour, Alexander Astrakhan, Michael Certo
  • CONSOLIDATED DATA RESTORATION FRAMEWORK
    Publication number: 20220004465
    Abstract: Embodiments of the present invention provide a system for identifying occurrence of events and performing one or more actions to mitigate the impacts of the events. The system is configured for gathering data from one or more data sources of an entity, generating dataflows using the data gathered from the one or more data sources, identifying an anomaly based on one or more indicators and the dataflows, determining occurrence of an event and generating one or more propagation models associated with the event, performing event impact analysis based on the one or more propagation models, perform one or more actions to contain the event based on the one or more propagation models, identifying a last good copy of data based on the data gathered from the one or more data sources, retrieving the last good copy of data, and restoring the last good copy of data.
    Type: Application
    Filed: July 6, 2021
    Publication date: January 6, 2022
    Applicant: BANK OF AMERICA CORPORATION
    Inventors: Christopher Emmanuel Huntley, Musa Ajakaiye, Prasad V. Annadata, Dnyanesh P. Ballikar, Sina Bauer, Jason Kenneth Bellew, Timothy John Bendel, David Alan Beumer, Michelle Andrea Boston, Lisa Julia Brown, Robin J. Buck, Brian C. Busch, Salvatore Michael Certo, Ramesh Naidu Chatta, Lisa Michelle Cook, Joseph Corbett, Joseph Seth Cushing, Steven Paul Davidson, Shailesh Deshpande, Sevara Ergasheva, Maria Ervin, James Wilson Foy, JR., Noel Mary Fuller, Benjamin Judson Gaines, III, Candace Gordon, Jesse Antonio Hernandez, Christine Hoagland, Robert Charles Hoard, Michael Spiro Karafotis, Wesley Keville, Sandip Kumar, Terri Dorinda Lail, Mukesh Maraj, Wyatt Edward Maxey, Dari Ann McKenzie, Ashley Meadows, Heather Newell, Conor Mitchell Liam Nodzak, Kenyell Javon Ollie, Jayshree G. Patel, David John Perro, Nivetha Raghavan, Nikhil Ram, Tara Michel Ramirez, Laurie Readhead, Mary Kathleen Riley, Elizabeth Rachel Rock, Angela Dawn Roose, Sanjay Singeetham, Kyle S. Sorensen, Shreyas Srinivas, Constance Jones Suarez, Viresh Taskar, Linda Trent, Sachin Varule, Bradley Walton, Christie M. Weekley, Yvette Alston, Ravi K. Bandaru, Carmen R. Barnhill, Joseph Benet, Jamie Gilchrist, Namrata Kaushik, Fernando A. Maisonett
  • SYSTEM FOR REINFORCING RESOURCE INTEGRITY BASED ON EVENT IMPACT ANALYSIS
    Publication number: 20210182269
    Abstract: Embodiments of the present invention provide a system for reinforcing resource integrity of one or more resources based on performing event impact analysis. The system is configured for determining occurrence of an event based on identifying one or more triggers, performing event impact analysis associated with one or more resources of an entity, and initiating an event response based on performing event impact analysis, wherein the event response comprises initiating one or more actions to reinforce and retain resource integrity of the one or more resources.
    Type: Application
    Filed: December 11, 2019
    Publication date: June 17, 2021
    Applicant: BANK OF AMERICA CORPORATION
    Inventors: Salvatore Michael Certo, Timothy J. Bendel, Robin Jennifer Buck, Christine B. Hoagland, Todd Lowney, Ashley Diane Meadows
  • PCSK9 ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE
    Publication number: 20200376140
    Abstract: The present disclosure provides improved genome editing compositions and methods for editing a PCSK9 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of hypercholesterolemia or a condition associated therewith.
    Type: Application
    Filed: October 4, 2018
    Publication date: December 3, 2020
    Applicant: bluebird bio, Inc.
    Inventors: JORDAN JARJOUR, KYLE HAVENS, MICHAEL CERTO, MAX ECHTERLING
  • MULTIPARTITE SIGNALING PROTEINS AND USES THEREOF
    Publication number: 20200071399
    Abstract: The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
    Type: Application
    Filed: August 14, 2019
    Publication date: March 5, 2020
    Applicant: bluebird bio, Inc.
    Inventors: Jordan Jarjour, Alexander Astrakhan, Michael Certo
  • MULTIPARTITE SIGNALING PROTEINS AND USES THEREOF
    Publication number: 20200071401
    Abstract: The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
    Type: Application
    Filed: September 17, 2019
    Publication date: March 5, 2020
    Applicant: bluebird bio, Inc.
    Inventors: Jordan JARJOUR, Alexander ASTRAKHAN, Michael CERTO
  • Multipartite signaling proteins and uses thereof
    Patent number: 10457731
    Abstract: Nucleic acids that encode chemically-inducible fusion proteins, vectors that contain nucleic acids that encode chemically-inducible fusion proteins, chemically-inducible fusion proteins, chemically-inducible fusion protein complexes, and non-natural cells that are modified to express chemically-inducible fusion proteins to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: October 29, 2019
    Assignee: bluebird bio, Inc.
    Inventors: Jordan Jarjour, Alexander Astrakhan, Michael Certo
  • Multipartite signaling proteins and uses thereof
    Patent number: 10428142
    Abstract: The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: October 1, 2019
    Assignee: bluebird bio, Inc.
    Inventors: Jordan Jarjour, Alexander Astrakhan, Michael Certo
  • MULTIPARTITE SIGNALING PROTEINS AND USES THEREOF
    Publication number: 20190112372
    Abstract: The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 18, 2019
    Applicant: bluebird bio, Inc.
    Inventors: Jordan JARJOUR, Alexander ASTRAKHAN, Michael CERTO
  • Multipartite signaling proteins and uses thereof
    Patent number: 10196444
    Abstract: The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: February 5, 2019
    Assignee: bluebird bio, Inc.
    Inventors: Jordan Jarjour, Alexander Astrakhan, Michael Certo
  • MULTIPARTITE SIGNALING PROTEINS AND USES THEREOF
    Publication number: 20160311901
    Abstract: The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
    Type: Application
    Filed: July 23, 2014
    Publication date: October 27, 2016
    Inventors: Jordan JARJOUR, Alexander ASTRAKHAN, Michael CERTO
  • MULTIPARTITE SIGNALING PROTEINS AND USES THEREOF
    Publication number: 20150266973
    Abstract: The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
    Type: Application
    Filed: January 28, 2015
    Publication date: September 24, 2015
    Inventors: Jordan JARJOUR, Alexander ASTRAKHAN, Michael CERTO