Abstract: The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms and/or headaches (e.g., migraine, cluster headache, and tension headache) by administering an anti-CGRP antagonist antibody. Compositions for use in the disclosed methods are also provided. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.

Abstract: Systems for modeling a digital articulator may include a processor in electronic communication with an extraoral imaging device and an intraoral imaging device and a non-transitory computer readable medium having instructions stored thereon that when executed by the processor capture 3D data of the patient's face in with the extraoral imaging device, capture a 3D model of the patient's dentition, align the 3D model of the patient's dentition with 3D data of the patient's face, generate an estimate of the temporomandibular joint characteristics based on the 3D model of the patient's face, and derive digital articular settings for a digital articular based on the 3D model of the patient's dentition with the 3D data of the patient's face and the estimate of the temporomandibular joint characteristics.

Abstract: Video game studio simulation game simulates the development of video games by selection and play of video game features. Players set a video game genre as displayed on cards in their hand. Players are granted a set amount of video game studio start-up funds. Game play is achieved by drawing cards from different card decks: gameplay feature deck, genre deck, benefit risk deck, CEO & Studio Deck, and market deck. Players may select and play various features for their video game. Launch success is determined by the prevailing game market shown by drawing market cards. Winner is determined by a dice roll related to matching a player's genre and features to the prevailing game market and a pitch to an investor, either artificial intelligence driven or human.

Abstract: A method may include obtaining a first 3D model of an upper jaw of a patient using an intraoral scanner and obtaining a second 3D model of the lower jaw of the patient using the intraoral scanner. The method may also include capturing a series of 2D images of the upper and lower jaws of the patient as the patient is moves the upper jaw and lower jaw in dynamic occlusion and processing the captured series of 2D images to identify features associated with the upper jaw of the patient and the lower jaw of the patient. For each 2D image in the captured series of 2D images, the method may include identifying a relative position of the first 3D model and the second 3D model based on alignment of features in the first 3D model and second 3D model with the features identified in the 2D image to generate a series of relative positions of the first 3D model and the second 3D model.

Abstract: A method is provided for assessing and categorizing temporomandibular disorder (TMD). In some cases, the method can include receiving data representing a potential for TMD of a patient. The method can include processing the data to identify an indicator of the TMD. The method can include identifying a treatment recommendation based on the indicator of the TMD. The method can include providing the treatment recommendation for display on a user device.

Abstract: Presented herein are systems and methods of authenticating clients to access data via proxy layers. A gateway on a proxy layer may receive a request from a client to access data in a compartment on the database layer. The request may include a token based at least on an encryption of an identifier of the compartment responsive to successful authentication of the request at an application layer. The gateway may, responsive to identifying the identifier as referencing the compartment, determine that the client is authorized to access the data in the compartment on the database layer through the proxy layer. The gateway may select a permission for the client to access the compartment through the proxy layer based on the context of the request. The gateway may generate an indication that the client is authorized to access the data in accordance with the permission.

Abstract: A push gateway brokers messages between backend services and client devices connected to the gateway. The gateway includes a plurality of messaging frontend servers, a messaging database, and a plurality of topic servers. The messaging frontend servers manage the socket connections connecting the client devices to the push gateway. The messaging database is a key-value database that subscribes messaging frontend servers to topics. The topic servers receive publish requests from the backend servers to identify subscribed messaging frontend servers in the messaging database to push messages out to. The frontend messaging servers subsequently push out the message to the client devices subscribed to the topic. The gateway can aggregate player counts from a plurality of geographical regions based on the socket connections hosted by the messaging frontend servers. With the player counts, the gateway can generate a player density map, e.g., for socket load balancing, or for a gameplay feature.

Abstract: A method is provided for measuring and categorizing gingival recession. In some cases, the method can include receiving intraoral scan data of a dentition of a patient. The method can include segmenting the intraoral scan data into a plurality of oral structures that comprise at least a tooth in the dentition of the patient, a gingiva, and a representation of an intersection between a first portion of the tooth and a second portion of the tooth. The method can include determining a gingival recession measurement indicative of a distance between the gingiva and the intersection. The method can include providing, to the user device, the gingival recession measurement.

Abstract: A micropuncture kit for direct access of a surgically exposed vessel using direct visual guidance includes a micropuncture access needle having a proximal hub coupled to an elongate shaft defining an inner lumen and a visible depth indicator positioned on the elongate shaft a distance away from a distal tip of the elongate shaft. The kit includes an access guidewire sized to be received through the inner lumen of the micropuncture access needle and a microaccess cannula having an elongate body defining an inner lumen and a plurality of visible depth indicators formed on the elongate body. The guidewire includes a distal tip and at least one visible depth indicator positioned on the access guidewire a distance away from the distal tip of the guidewire. Each of the plurality of visible depth indicators identifies a distance from a distal tip of the cannula. Related systems, devices and methods are provided.

Abstract: Presented herein are systems and methods of authenticating clients to access data via proxy layers. A gateway on a proxy layer may receive a request from a client to access data in a compartment on the database layer. The request may include a token based at least on an encryption of an identifier of the compartment responsive to successful authentication of the request at an application layer. The gateway may, responsive to identifying the identifier as referencing the compartment, determine that the client is authorized to access the data in the compartment on the database layer through the proxy layer. The gateway may select a permission for the client to access the compartment through the proxy layer based on the context of the request. The gateway may generate an indication that the client is authorized to access the data in accordance with the permission.

Abstract: Systems, apparatuses, and methods disclosed herein are directed to systems, methods, and apparatuses for enabling a patient to capture intra-oral images and for the processing of those images to assist a dentist or orthodontist in evaluating the state of a patient's teeth and the development or progress of a treatment plan.

Abstract: A push gateway brokers messages between backend services and client devices connected to the gateway. The gateway includes a plurality of messaging frontend servers, a messaging database, and a plurality of topic servers. The messaging frontend servers manage the socket connections connecting the client devices to the push gateway. The messaging database is a key-value database that subscribes messaging frontend servers to topics. The topic servers receive publish requests from the backend servers to identify subscribed messaging frontend servers in the messaging database to push messages out to. The frontend messaging servers subsequently push out the message to the client devices subscribed to the topic. The gateway can aggregate player counts from a plurality of geographical regions based on the socket connections hosted by the messaging frontend servers. With the player counts, the gateway can generate a player density map, e.g., for socket load balancing, or for a gameplay feature.

Abstract: Methods and systems are described for 3D modeling and visualization of a patient's facial structure and features for dental treatment planning.

Abstract: Presented herein are systems and methods of authenticating clients to access data via proxy layers. A gateway on a proxy layer may receive a request from a client to access data in a compartment on the database layer. The request may include a token based at least on an encryption of an identifier of the compartment responsive to successful authentication of the request at an application layer. The gateway may, responsive to identifying the identifier as referencing the compartment, determine that the client is authorized to access the data in the compartment on the database layer through the proxy layer. The gateway may select a permission for the client to access the compartment through the proxy layer based on the context of the request. The gateway may generate an indication that the client is authorized to access the data in accordance with the permission.

Abstract: A method includes obtaining first data of a dental arch having one or more first properties. The method further includes processing the first data using one or more trained machine learning models. The one or more trained machine learning models generate a dimensionally reduced representation of the dental arch based on the first data. The one or more trained machine learning models generate second data of the dental arch that has one or more second properties. The method further includes obtaining, from the one or more trained machine learning models, the second data of the dental arch that has the one or more second properties. The second data is based on the dimensionally reduced representation. The one or more second properties are different from the one or more first properties. The method further includes causing a representation of the dental arch to be displayed based on the second data.

Abstract: A micropuncture kit for direct access of a surgically exposed vessel using direct visual guidance includes a micropuncture access needle having a proximal hub coupled to an elongate shaft defining an inner lumen and a visible depth indicator positioned on the elongate shaft a distance away from a distal tip of the elongate shaft. The kit includes an access guidewire sized to be received through the inner lumen of the micropuncture access needle and a microaccess cannula having an elongate body defining an inner lumen and a plurality of visible depth indicators formed on the elongate body. The guidewire includes a distal tip and at least one visible depth indicator positioned on the access guidewire a distance away from the distal tip of the guidewire. Each of the plurality of visible depth indicators identifies a distance from a distal tip of the cannula. Related systems, devices and methods are provided.

Abstract: An example method includes receiving, by a computing system, from an aggregator computing system, an access request of an account at a financial institution, the access request including a user identifier associated with a user of the account and encrypted authentication information; decrypting, by the computing system, the encrypted authentication information; matching, by the computing system, the decrypted authentication information against stored authentication information associated with the user identifier of the user; and providing, by the computing system, an authentication decision to the aggregator computing system, the authentication decision enabling the aggregator computing system to access and display information of the account to the user.

Abstract: A micropuncture kit for direct access of a surgically exposed vessel using direct visual guidance includes a micropuncture access needle having a proximal hub coupled to an elongate shaft defining an inner lumen and a visible depth indicator positioned on the elongate shaft a distance away from a distal tip of the elongate shaft. The kit includes an access guidewire sized to be received through the inner lumen of the micropuncture access needle and a microaccess cannula having an elongate body defining an inner lumen and a plurality of visible depth indicators formed on the elongate body. The guidewire includes a distal tip and at least one visible depth indicator positioned on the access guidewire a distance away from the distal tip of the guidewire. Each of the plurality of visible depth indicators identifies a distance from a distal tip of the cannula. Related systems, devices and methods are provided.

Abstract: An example method includes receiving an encrypted biometric enrollment data and user identifier data. The encrypted biometric enrollment data includes at least one biometric enrollment sample from a user encrypted using an encryption key. The encryption key is generated based on a user secret and the user identifier is associated with the user. The user identifier is matched with a stored user secret. A decryption key is generated based on the stored user secret. The encrypted biometric enrollment data is decrypted using the decryption key. The at least one biometric enrollment sample is retrieved from the decrypted biometric enrollment data. The at least one biometric enrollment sample is processed using a biometric processing algorithm to generate a biometric reference template. A biometric reference template identifier uniquely identifying the biometric reference template is generated. An encryption key is generated based on the stored user secret and encrypts an enrollment confirmation message.

Abstract: Methods and systems are described that use a three-dimensional (3D) model of a dental site to generate a panoramic two-dimensional (2D) image of the dental site. In one example, a method includes receiving a 3D model of the dental site generated at least in part from an intraoral scan, generating a surface shaped to substantially surround a dental arch represented by the dental site, computing a surface projection by projecting the dental site onto the surface, and generating the panoramic 2D image from the surface projection.