Abstract: Provided herein are chimeric transmembrane receptor polypeptides configured to oligomerize upon recognition of an extramembrane signal. The receptors include an extramembrane domain, a transmembrane domain, and an intramembrane domain configured to induce activation of one or more intramembrane signal pathways upon oligomerization of the receptor. The provided receptors are particularly useful for engineered cell therapies. Also provided are systems and host cells including the disclosed receptors, and methods for using the disclosed materials.

Abstract: A toothbrush container assembly for use with a toothbrush and for mounting in a wall including a base having a first aperture therein, a slot adjacent said first aperture, an interior reservoir, a second aperture leading from the reservoir to the exterior of the base, the second aperture including a first fastener and means for securing the base to the wall, and a toothbrush container assembly having a cap including a second fastener; a central housing including first and second ends, a third fastener disposed at the first end and adapted to removably engage the second fastener, a fourth fastener disposed at the second end of the housing and adapted to removably engage said first fastener; and engaging hook disposed intermediate the first and second ends and adapted to removably engage the slot; an interior shoulder to support the toothbrush while within the container; a first, perforated, bottom member having a fifth fastener adapted to removably engage the fourth fastener; and a second, imperforate, bottom