Patents by Inventor Michael Chesney

Michael Chesney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR IMPROVING SEQUENCING SIGNALS
    Publication number: 20230357845
    Abstract: Embodiments of the present disclosure relate to compositions and kits for use in sequencing by synthesis to improve fluorescent signal intensity and reduce signal decay caused by short wavelength light source during the imaging events. Methods of sequencing using the compositions and kits described herein are also provided.
    Type: Application
    Filed: March 29, 2023
    Publication date: November 9, 2023
    Inventors: Huihong YOU, Samuel CABER, Michael CHESNEY, Jie MAO, Alexandre RICHEZ, Rebecca MACLEOD, Emily WELCH, Zhong MEI, Xiaolin WU, Carole ANASTASI, Alexander FUHRMANN
  • PURIFYING AND POLYMERIZING 3'-BLOCKED NUCLEOTIDES
    Publication number: 20220389500
    Abstract: A method for purifying nucleotides is provided, that includes preparing a solution comprising (a) 3?-blocked nucleotides, (b) 3?-OH nucleotides, (c) a polishing polymerase, and (d) a template. The polishing polymerase and the template are used to selectively polymerize the 3?-OH nucleotides and thus reduce a concentration in the solution of the 3?-OH nucleotides relative to the 3?-blocked nucleotides.
    Type: Application
    Filed: May 19, 2022
    Publication date: December 8, 2022
    Applicants: ILLUMINA, INC., ILLUMINA CAMBRIDGE LIMITED
    Inventors: Kim Schneider, Jason Betley, Oliver Miller, Bradley Drews, Dominic Smith, Rajagopal Panchapakesan, Patrick McCauley, Stephen Mason, Tommaso Moschetti, Michael Chesney, Marta Richardson, Elliot Lawrence, Amanda Jackson, Rosamond Jackson, Erin Imsand, Henry Day
  • Compositions and methods for improving sample identification in indexed nucleic acid libraries
    Patent number: 11459610
    Abstract: The present invention is concerned with compositions and methods for improving the rate of correct sample identification in indexed nucleic acid library preparations for multiplex next generation sequencing by exonuclease treatment and optionally blocking the 3? ends of pooled indexed polynucleotides from multiple samples prior to amplification and sequencing.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: October 4, 2022
    Assignee: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Michael Chesney, Vincent Peter Smith, Claire Bevis-Mott, Jonathan Mark Boutell, Angela Kalbande
  • COMPOSITIONS AND METHODS FOR IMPROVING SAMPLE IDENTIFICATION IN INDEXED NUCLEIC ACID LIBRARIES
    Publication number: 20210230689
    Abstract: The present invention is concerned with compositions and methods for improving the rate of correct sample identification in indexed nucleic acid library preparations for multiplex next generation sequencing by blocking the 3? ends of pooled indexed polynucleotides from multiple samples prior to amplification and sequencing, by exonuclease treatment and optionally blocking the 3? ends of pooled indexed polynucleotides from multiple samples prior to amplification and sequencing, by exonuclease treatment after protective adapters are ligated to target polynucleotides to degrade unincorporated adapters prior to amplification and sequencing, and/or by modifying or blocking 5? and 3? ends of pooled indexed polynucleotides from multiple samples, with an optional exonuclease treatment, prior to amplification and sequencing.
    Type: Application
    Filed: April 12, 2021
    Publication date: July 29, 2021
    Applicants: Illumina, Inc., Ilumina Cambridge Limited
    Inventors: Eric Vermaas, Mahdieh Khosroheidari, Angela Kalbande, Vincent Peter Smith, Claire Bevis-Mott, Jonathan Mark Boutell, Michael Chesney
  • COMPOSITIONS AND METHODS FOR IMPROVING SAMPLE IDENTIFICATION IN INDEXED NUCLEIC ACID LIBRARIES
    Publication number: 20180305753
    Abstract: The present invention is concerned with compositions and methods for improving the rate of correct sample identification in indexed nucleic acid library preparations for multiplex next generation sequencing by exonuclease treatment and optionally blocking the 3? ends of pooled indexed polynucleotides from multiple samples prior to amplification and sequencing.
    Type: Application
    Filed: April 23, 2018
    Publication date: October 25, 2018
    Applicant: Illumina Cambridge Limited
    Inventors: Michael Chesney, Vincent Peter Smith, Claire Bevis-Mott, Jonathan Mark Boutell, Angela Kalbande