Abstract: Methods of administering a myosin inhibitor to a patient and related methods of risk mitigation including controls on distribution are described herein. Methods disclosed herein provide for safe administration of mavacamten and other myosin inhibitors, and mitigate the risk of heart failure due to systolic dysfunction.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: In some implementations, a method of synchronizing a content generation and delivery architecture to reduce the latency associated with image passthrough. The method includes: determining a temporal offset associated with the content generation and delivery architecture to reduce a photon-to-photon latency across the content generation and delivery architecture; obtaining a first reference rate associated with a portion of the content generation and delivery architecture; generating, via synchronization circuitry, a synchronization signal for the content generation and delivery architecture based at least in part on the first reference rate; and operating the content generation and delivery architecture according to the synchronization signal and the temporal offset.

Abstract: Systems, apparatuses, and methods for charging a bootstrap capacitor of a device during low power states are described. In an example, an apparatus can include a controller configured to enable a low power state of the device. The device can include a high side switching element and a low side switching element. The controller can, in response to the low power state of the device being enabled, operate the low side switching element of the device to charge the bootstrap capacitor of the device. The controller can, in response to the low power state of the device being enabled and a level of a control signal being a first level, activate the low side switching element to charge the bootstrap capacitor of the device.

Abstract: Water-resistant waterborne acrylic coating materials, systems and methods providing enhanced water resistance and durability are provided. Such coatings extend the service life of roofing systems that are exposed to ponding water and other extreme weather conditions. Coatings described herein exhibit superior water resistance attributes including one or more of water infiltration resistance, wet tensile strength and wet adhesion.

Abstract: An equipment inspection system receives data captured by a sensor of an autonomous vehicle (AV). The captured data describes a current state of equipment for servicing the AV. The equipment inspection system compares the captured data to a model describing an expected state of the equipment. The equipment inspection system determines, based on the comparison, that the equipment differs from the expected state. The equipment inspection system may transmit data describing the current state of the equipment to an equipment manager. The equipment manager may schedule maintenance for the equipment based on the current state of the equipment.

Abstract: Methods of administering a myosin inhibitor to a patient and related methods of risk mitigation including controls on distribution are described herein. Methods disclosed herein provide for safe administration of mavacamten and other myosin inhibitors, and mitigate the risk of heart failure due to systolic dysfunction.

Abstract: A physical storage vault for physical items of digital twin NFTs is described. A combined listing for a physical item and an NET of the physical item is generated, and the combined listing is output in a user interface at a client device. The user interface includes an option to store the physical item in a physical storage vault. A request is received from the client device to transfer ownership of the physical item and the NFT of the combined listing to a user account. The request indicates that the option to store the physical item in the physical storage vault is accepted. Responsive to the request, transfer of ownership of the NET to the user account is initiated by encoding metadata of the NFT on a blockchain with an identifier associated with the user account and by storing the physical item in the physical storage vault.

Abstract: Systems for managing operating on folders that comprise a large number of objects in a cloud-based collaboration platform. A cloud-based environment includes storage devices that store content objects accessible by collaborating users. The content objects are identified by one or more hierarchical path identifiers comprising a folder identifier corresponding to a logical grouping. The hierarchical path identifiers are stored in a relational database. Methods receive an operation command from a user to operate on the content objects associated with the logical grouping, after which a relational database search query is generated. Processing of the query returns a plurality of result sets corresponding to respective portions of the content objects associated with the logical grouping. The operation command is applied iteratively over the plurality of result sets, and the command is finalized after the last iteration.

Abstract: A waste disposal system includes a cassette having a latch feature. The latch feature is received within a cassette interface or secured by a cassette interface. A waste disposal device includes a lid that mitigates disturbance of ambient air surrounding the waste disposal device. A liner clamping system has an associated timing that mitigates against air within the interior space of the waste disposal device from travelling upward through the liner clamping system, past the lid (when the lid is in an open configuration) and outward into the surrounding environment.

Abstract: Systems for managing operating on folders that comprise a large number of objects in a cloud-based collaboration platform. A cloud-based environment includes storage devices that store content objects accessible by collaborating users. The content objects are identified by one or more hierarchical path identifiers comprising a folder identifier corresponding to a logical grouping. The hierarchical path identifiers are stored in a relational database. Methods receive an operation command from a user to operate on the content objects associated with the logical grouping, after which a relational database search query is generated. Processing of the query returns a plurality of result sets corresponding to respective portions of the content objects associated with the logical grouping. The operation command is applied iteratively over the plurality of result sets, and the command is finalized after the last iteration.

Abstract: A therapeutic ischemic and reperfusion device with an associated monitoring system for generally enhancing the vascular and metabolic environment and wellbeing of a subject. A method for the treatment and prophylaxis of various medical conditions including environmental induced oxidative stress using the therapeutic ischemic and reperfusion device and associated monitoring system is also contemplated herein. The method uses an inflatable cuff around the limb or torso of a subject operated by a controller configured to inflate and deflate the cuff. The monitoring system is used to monitor the physical and metabolic environments of the subject during and subsequent to the ischemia and reperfusion.