Patents by Inventor Michael Choma
Michael Choma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11953505Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.Type: GrantFiled: June 29, 2021Date of Patent: April 9, 2024Assignee: Yale UniversityInventors: Irina Buhimschi, Catalin S. Buhimschi, Michael Choma, Hemant Tagare, Stephan Michael Jonas
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Publication number: 20220043001Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.Type: ApplicationFiled: June 29, 2021Publication date: February 10, 2022Applicant: Yale UniversityInventors: Irina Buhimschi, Catalin S. Buhimschi, Michael Choma, Hemant Tagare, Stephan Michael Jonas
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Patent number: 11079392Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.Type: GrantFiled: May 8, 2019Date of Patent: August 3, 2021Assignee: Yale UniversityInventors: Irina Buhimschi, Catalin S. Buhimschi, Michael Choma, Hemant Tagare, Stephan Michael Jonas
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Publication number: 20190353662Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.Type: ApplicationFiled: May 8, 2019Publication date: November 21, 2019Applicant: Yale UniversityInventors: Irina Buhimschi, Catalin S. Buhimschi, Michael Choma, Hemant Tagare, Stephan Michael Jonas
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Patent number: 10432871Abstract: Systems and methods are provided for imaging using complex lasers. In general, a complex laser may be used as an electromagnetic source for an imaging application. The use of a lower spatial coherence configured complex laser in imaging applications may advantageously mitigate coherent artifacts in imaging such as cross-talk and speckle and improve overall image quality. Imaging applications where a complex laser may be useful include both incoherent imaging applications, such as digital light projectors and traditional microscopy, and coherent imaging applications, such as optical coherence tomography (OCT) and holography. The systems and methods provided also enable controlling the degree of spatial coherence of a complex laser.Type: GrantFiled: April 16, 2012Date of Patent: October 1, 2019Assignee: Yale UniversityInventors: Hui Cao, Brandon Redding, Michael Choma
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Patent number: 10324094Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.Type: GrantFiled: April 10, 2015Date of Patent: June 18, 2019Assignee: Yale UniversityInventors: Irina Buhimschi, Catalin S. Buhimschi, Michael Choma, Hemant Tagare, Stephan Michael Jonas
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Publication number: 20150293115Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.Type: ApplicationFiled: April 10, 2015Publication date: October 15, 2015Applicant: YALE UNIVERSITYInventors: IRINA BUHIMSCHI, CATALIN S. BUHIMSCHI, MICHAEL CHOMA, HEMANT TAGARE, STEPHAN MICHAEL JONAS
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Publication number: 20140111671Abstract: Systems and methods are provided for imaging using complex lasers. In general, a complex laser may be used as an electromagnetic source for an imaging application. The use of a lower spatial coherence configured complex laser in imaging applications may advantageously mitigate coherent artifacts in imaging such as cross-talk and speckle and improve overall image quality. Imaging applications where a complex laser may be useful include both incoherent imaging applications, such as digital light projectors and traditional microscopy, and coherent imaging applications, such as optical coherence tomography (OCT) and holography. The systems and methods provided also enable controlling the degree of spatial coherence of a complex laser.Type: ApplicationFiled: April 16, 2012Publication date: April 24, 2014Applicant: YALE UNVIVERSITYInventors: Hui Cao, Brandon Redding, Michael Choma
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Patent number: 8077325Abstract: Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position.Type: GrantFiled: December 9, 2009Date of Patent: December 13, 2011Assignee: Duke UniversityInventors: Michael Choma, Joseph A. Izatt, Audrey Ellerbee, Marinko Sarunic
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Publication number: 20100201991Abstract: Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position.Type: ApplicationFiled: December 9, 2009Publication date: August 12, 2010Applicant: Duke UniversityInventors: Michael Choma, Joseph A. Izatt, Audrey Ellerbee, Marinko Sarunic
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Patent number: 7633627Abstract: Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position.Type: GrantFiled: January 20, 2006Date of Patent: December 15, 2009Assignee: Duke UniversityInventors: Michael Choma, Joseph A. Izatt, Audrey Ellerbee, Marinko Sarunic
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Patent number: 7336366Abstract: A complex conjugate ambiguity can be resolved in an Optical Coherence Tomography (OCT) interferogram. A reference light signal is propagated along a reference path. A sample light signal is impinged on a sample reflector. The reference light signal is frequency shifted with respect to the sample light signal to thereby separate a positive and a negative displacement of a complex conjugate component of the OCT interferogram.Type: GrantFiled: January 20, 2006Date of Patent: February 26, 2008Assignee: Duke UniversityInventors: Michael Choma, Joseph A. Izatt, Anjul Davis
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Publication number: 20060256343Abstract: Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position.Type: ApplicationFiled: January 20, 2006Publication date: November 16, 2006Inventors: Michael Choma, Joseph Izatt, Audrey Ellerbee, Marinko Sarunic
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Publication number: 20060232783Abstract: A complex conjugate ambiguity can be resolved in an Optical Coherence Tomography (OCT) interferogram. A reference light signal is propagated along a reference path. A sample light signal is impinged on a sample reflector. The reference light signal is frequency shifted with respect to the sample light signal to thereby separate a positive and a negative displacement of a complex conjugate component of the OCT interferogram.Type: ApplicationFiled: January 20, 2006Publication date: October 19, 2006Inventors: Michael Choma, Joseph Izatt, Anjul Davis
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Patent number: 7075658Abstract: Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.Type: GrantFiled: January 26, 2004Date of Patent: July 11, 2006Assignees: Duke University, Case Western Reserve UniversityInventors: Joseph A. Izatt, Divakar K. Rao, Changhuei Yang, Michael A. Choma, Siavash Yazdanfar, Andrew M. Rollins, Brian E. Applegate
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Patent number: 7019838Abstract: A quadrature broadband interferometry system and method obtains a complete complex interferometric signal instantaneously in both homodyne and heterodyne systems in a simple, compact, and inexpensive setup. This is accomplished by separating interferometric components from non-interferometric components in each of at least two detector signals of an interferometer having a number of N×N couplers, scaling the interferometric components, and generating real and imaginary parts of a complex interferometric signal from the scaled interferometric components. The detector signals preferably derive from a broadband light source coupled to the interferometer, and the number of N×N couplers may be one or more, with N?3.Type: GrantFiled: May 28, 2004Date of Patent: March 28, 2006Assignee: Duke UniversityInventors: Joseph A. Izatt, Michael Choma, Changhuei Yang
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Publication number: 20050036150Abstract: Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.Type: ApplicationFiled: January 26, 2004Publication date: February 17, 2005Inventors: Joseph Izatt, Divakar Rao, Changhuei Yang, Michael Choma, Siavash Yazdanfar, Andrew Rollins, Brian Applegate
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Publication number: 20040239943Abstract: A quadrature broadband interferometry system and method obtains a complete complex interferometric signal instantaneously in both homodyne and heterodyne systems in a simple, compact, and inexpensive setup. This is accomplished by separating interferometric components from non-interferometric components in each of at least two detector signals of an interferometer having a number of N×N couplers, scaling the interferometric components, and generating real and imaginary parts of a complex interferometric signal from the scaled interferometric components. The detector signals preferably derive from a broadband light source coupled to the interferometer, and the number of N×N couplers may be one or more, with N≧3.Type: ApplicationFiled: May 28, 2004Publication date: December 2, 2004Applicant: DUKE UNIVERSITYInventors: Joseph A. Izatt, Michael Choma, Changhuei Yang
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Patent number: 5307784Abstract: An induction system for a multicylinder reciprocating internal combustion engine includes cylinder 8, cylinder head 10 having at least one intake poppet valve 12, and at least one exhaust poppet valve 14, with the induction system further including a crankcase ventilation system 26 for conducting gases from the crankcase of the engine to the cylinder head, and a PCV passage for introducing crankcase gases directly into at least one of the engine's intake ports 18. In the case wherein multiple intake valves and ports are used, PCV flow may be introduced through one port, with recirculated exhaust gas being introduced through a second intake port.Type: GrantFiled: April 5, 1993Date of Patent: May 3, 1994Assignee: Ford Motor CompanyInventors: Michael A. Choma, William F. Stockhausen, Timo A. Wiemero
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Patent number: 5277160Abstract: An internal combustion engine having a single intake valve which is fed fresh charge by primary and secondary port passages has an essentially flat combustion chamber with the spark plug and primary port passages being arranged to achieve a rapid burn rate.Type: GrantFiled: December 21, 1992Date of Patent: January 11, 1994Assignee: Ford Motor CompanyInventors: Michael A. Choma, Philip W. Husak, William F. Stockhausen