Abstract: A seal assembly for insertion into a hollow body organ is provided. The assembly includes a tubular hollow extrusion having a proximal end, a distal end and an interior surface between the proximal end and the distal end. A proximal balloon is located at the proximal end of the extrusion and a distal balloon is located at the distal end of the extrusion. An expandable scaffold engages the interior surface of the extrusion.

Abstract: A method for confined and controlled treatment of a target area of an internal body lumen using negative pressure applied to the target area, the method permitting treatment to proceed without interrupting the flow of bodily fluid through the body lumen, the method including deploying a resilient stent having a liner to define the target area and passages within the liner connected to a catheter tube so that the negative pressure may be applied through a lumen of the catheter tube from a source connected to the catheter tube without impacting the inflated stent and without impacting the ability of body lumen fluid to flow through the stent, thereby permitting therapy to proceed without disrupting the natural flow of bodily fluids or the delivery of nutrients within the body lumen during therapy.

Abstract: A medical device consists of a dual lumen catheter with three intra-connecting balloons comprising a balloon stent. The adjustable tissue approximation using negative pressure exerted between device and mucosa of stomach/esophagus/colon with improved injury site isolation via adjustable balloon stent and added potential of negative pressure application to injury site for active healing process and distal feeding potential.