Patents by Inventor Michael Clare

Michael Clare has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Retroviral protease inhibitors
    Publication number: 20050004230
    Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: March 5, 2004
    Publication date: January 6, 2005
    Applicant: Monsanto Company (now named Pharmacia Corporation, which is a wholly owned subsidiary of Pfizer, Inc
    Inventors: John Talley, Daniel Getman, Gary DeCrescenzo, Kathryn Reed, Ko-Chung Lin, John Freskos, Michael Clare, Donald Rogier, Robert Heintz, Michael Vazquez, Richard Mueller
  • Cycloalkyl alkanoic acids as integrin receptor antagonists
    Publication number: 20040259869
    Abstract: The present invention relates to a class of compounds represented by the Formula I 1
    Type: Application
    Filed: July 14, 2004
    Publication date: December 23, 2004
    Inventors: Ish Kumar Khanna, Michael Clare, Alan F. Gasiecki, Thomas Rogers, Barbara Chen, Hwang-Fun Lu
  • Dihydrostilbene alkanoic acid derivatives
    Patent number: 6833366
    Abstract: The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or the &agr;v&bgr;5 integrin.
    Type: Grant
    Filed: September 9, 2003
    Date of Patent: December 21, 2004
    Assignee: Pharmacia Corporation
    Inventors: Thomas Rogers, Michael Clare, Hwang-Fun Lu, Mark Russell, James W. Malecha, Ish Kumar Khanna, Thomas Penning, Srinivasan Raj Nagarajan
  • Pyrimidine compounds and derivatives thereof
    Patent number: 6831199
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, wherein A is pharmaceutical compositions thereof and methods of using such compounds and compositions as &agr;v&bgr;3 antagonists.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: December 14, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Peter Gerrard Ruminski, Michael Clare, Paul Waddell Collins, Bipinchandra Nanubhai Desai, Richard John Lindmark, Joseph Gerace Rico, Thomas Edward Rogers, Mark Andrew Russell
  • Substituted pyrazoles as p38 kinase inhibitors
    Publication number: 20040176433
    Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders.
    Type: Application
    Filed: February 25, 2003
    Publication date: September 9, 2004
    Inventors: Ashok S. Naraian, Michael Clare, Paul W. Collins, Joyce Zuowu Crich, Rajesh Devraj, Daniel L. Flynn, Lifeng Geng, Matthew J. Graneto, Cathleen E. Hanau, Gunnar J. Hanson, Susan J. Hartmann, Michael Hepperle, He Huang, Francis J. Koszyk, Shuyuan Liao, Suzanne Metz, Richard A. Partis, Thao D. Perry, Shashidhar N. Rao, Shaun Raj Selness, Michael S. South, Michael A. Stealey, John Jeffrey Talley, Michael L. Vazquez, Richard M. Weier, Xiangdong Xu, Ish K. Khanna, Yi Yu, Win Naing, Syaulan Yang
  • 3 (5) -heteroaryl substituted pyrazoles as p38 kinase inhibitors
    Publication number: 20040147579
    Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders.
    Type: Application
    Filed: June 6, 2003
    Publication date: July 29, 2004
    Inventors: Ashok S. Naraian, Michael Clare, Lifeng Geng, Gunnar J. Hanson, Richard A. Partis, Michael A. Stealey, Richard M. Weier
  • Retroviral protease inhibitors
    Patent number: 6762187
    Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: July 13, 2004
    Assignee: Monsanto Company
    Inventors: John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, Kathryn L. Reed, Ko-Chung Lin, John Nicholas Freskos, Michael Clare, Donald Joseph Rogier, Jr., Robert M. Heintz, Michael L. Vazquez, Richard A. Mueller
  • Substituted pyrazolyl compounds for the treatment of inflammation
    Publication number: 20040110741
    Abstract: The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
    Type: Application
    Filed: September 19, 2002
    Publication date: June 10, 2004
    Inventors: Arija A. Bergmanis, Michael Clare, Joyce Z. Crich, Lifeng Geng, Timothy J. Hagen, Gunnar J. Hanson, Stephen Houdek, He Huang, Donna M. Iula, Francis J. Koszyk, Shuyuan Liao, Scott B. Mohler, Maria Nguyen, Richard A. Partis, Michael A. Stealey, Michael B. Tollefson, Richard M. Weier, Xiangdong Xu, Dominique Bonafoux, Theresa R. Fletcher, Bruce C. Hamper, Patrick J. Lennon, Subo Liao, Suzanne Metz, David S. Oburn, Thomas J. Owen, Angela M. Scates, Michael L. Vazquez, Serge G. Wolfson
  • Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
    Publication number: 20040092538
    Abstract: The present invention relates to a class of compounds represented by the Formula I 1
    Type: Application
    Filed: December 20, 2002
    Publication date: May 13, 2004
    Inventors: Srinivasan R. Nagarajan, Ish Kumar Khanna, Michael Clare, Alan Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu, Yu Yi, Renee M. Huff, Bipinchandra N. Desai, Balekudru Devadas, Mihir D. Parikh, Thomas Penning
  • Substituted thiophene carboxamide compounds for the treatment of inflammation
    Publication number: 20040082602
    Abstract: The present invention provides substituted thiophene carboxamide compounds having structural Formula I and isomers, tautomers, polymorphs, carriers, prodrugs, and pharmaceutically acceptable salts thereof, compositions comprising such, and methods for treating diseases associated with kinase activity. More specifically, the present invention provides methods of treatment of a variety of diseases associated with IKK2 including the treatment of inflammation, other inflammation-associated disorders, such as, as an analgesic in the treatment of pain and headaches, arthritis, including but not limited to rheumatoid arthritis, asthma, gastrointestinal conditions such as inflammatory bowel disease, vascular diseases, viral infections such as AIDS, and cancer.
    Type: Application
    Filed: July 18, 2003
    Publication date: April 29, 2004
    Inventors: Timothy J. Hagen, Richard M. Weier, Xiangdong Xu, Stephen C. Houdek, Michael Clare
  • Methods and compositions for expressing a nucleic acid in a dendritic cell
    Publication number: 20040072351
    Abstract: Recombinant adeno-associated virus (rAAV) virions having a serotype 1 capsid protein are effective for transferring heterologous nucleic acids into DC.
    Type: Application
    Filed: April 30, 2003
    Publication date: April 15, 2004
    Inventors: Karl L. Womer, Sihong Song, Terence R. Flotte, Scott A. Loiler, Mark A. Atkinson, Michael Clare-Salzler, Jude Samulski, Chengwin Li
  • Dihydrostilbene alkanoic acid derivatives
    Patent number: 6720315
    Abstract: The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: April 13, 2004
    Assignee: Pharmacia Corporation
    Inventors: Thomas Rogers, Michael Clare, Hwang-Fun Lu, Mark Russell, James W. Malecha, Ish Kumar Khanna, Thomas Penning, Srinivasan Raj Nagarajan, Heather Stenmark
  • Cycloalkyl alkanoic acids as intergrin receptor antagonists
    Publication number: 20040043988
    Abstract: The present invention relates to a class of compounds represented by the Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or &agr;v &bgr;5 integrin.
    Type: Application
    Filed: August 21, 2003
    Publication date: March 4, 2004
    Inventors: Ish Kurmar Khanna, Michael Clare, Alan Gasiecki, Thomas Rogers, Barbara B. Chen, Mark Russell, Hwang-Fun Lu
  • Cyclic sulfone containing retroviral protease inhibitors
    Publication number: 20040010143
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Application
    Filed: February 20, 2003
    Publication date: January 15, 2004
    Applicants: G.D. Searle & Co., Pharmacia Corporation (Monsanto Company)
    Inventors: Deborah E. Bertenshaw, Daniel P. Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • Meta-substituted phenylene sulphonamide derivatives
    Patent number: 6677308
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 integrin.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: January 13, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Nizal Chandrakumar, Michael Clare, Wendell Doubleday, Alan F. Gasiecki, Mark A. Russell
  • Retroviral protease inhibitors
    Publication number: 20030195227
    Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: September 18, 2002
    Publication date: October 16, 2003
    Applicant: Monsanto Company
    Inventors: John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, Kathryn L. Reed, Ko-Chung Lin, John Nicholas Freskos, Michael Clare, Donald Joseph Rogier, Robert M. Heintz, Michael L. Vazquez, Richard A. Mueller
  • Substituted pyrazoles as p38 kinase inhibitors
    Patent number: 6617324
    Abstract: A class of pyrazole derivatives described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: September 9, 2003
    Assignee: G. D. Searle & Company
    Inventors: Ashok S. Naraian, Michael Clare, Paul W. Collins, Joyce Zuowu Crich, Rajesh Devraj, Daniel L. Flynn, Lifeng Geng, Matthew J. Graneto, Cathleen E. Hanau, Gunnar J. Hanson, Susan J. Hartmann, Michael Hepperle, He Huang, Francis J. Koszyk, Shuyuan Liao, Suzanne Metz, Richard A. Partis, Thao D. Perry, Shashidhar N. Rao, Shaun Raj Selness, Michael S. South, Michael A. Stealey, John Jeffrey Talley, Michael L. Vazquez, Richard M. Weier, Xiangdong Xi, Ish K. Khanna, Yi Yu
  • Substituted pyrazolyl benzenesulfamide compounds for the treatment of inflammation
    Publication number: 20030125361
    Abstract: The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
    Type: Application
    Filed: September 19, 2002
    Publication date: July 3, 2003
    Inventors: Michael Clare, Lifeng Geng, Gunnar J. Hanson, He Huang, Donna M. Iula, Shuyuan Liao, Michael A. Stealy, Richard M. Weier, Suzanne Metz, Michael L. Vazquez
  • Substituted pyrazolyl compounds for the treatment of inflammation
    Publication number: 20030114432
    Abstract: The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
    Type: Application
    Filed: September 19, 2002
    Publication date: June 19, 2003
    Inventors: Michael Clare, Joyce Z. Crich, Timothy J. Hagen, Gunnar J. Hanson, Stephen C. Houdek, He Huang, Richard M. Weier
  • 3 (5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors
    Patent number: 6579873
    Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I wherein R1, R2, Ar1 and HetAr2 are as described in the specification.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: June 17, 2003
    Assignee: Pharmacia Corporation
    Inventors: Ashok Anantanarayan, Michael Clare, Lifeng Geng, Gunnar J. Hanson, Richard A. Partis, Michael A. Stealey, Richard M. Weier