Abstract: The invention provides novel glucocorticosteroids, glucocorticosteroid-linkers and antibody drug conjugates (ADC's) comprising an antibody or antibody fragment which binds to an antigen expressed on immune cells, optionally an antigen expressed on human immune cells. In some instances the ADCs comprise an anti-human VISTA (V-region Immunoglobulin-containing Suppressor of T cell Activation (1)) antibody or anti-VISTA antigen-binding antibody fragment which binds to VISTA expressing cells at physiologic pH having a short serum half-life (?24-72 or 24-48 or 12-24 hours or less in a human VISTA knock-in rodent or ((?1-3.5 days or less in a human or non-human primate). In some instances these ADCs have a rapid onset of action and are potent for prolonged duration as they are very effectively internalized by immune cells in large amounts where they are cleaved releasing large amounts of active steroid payload.

Abstract: Arrangements for steganography-based security document access control are provided. In some examples, a security policy for a document may be generated. The security policy may include identification of one or more users authorized to access the document and one or more response actions to execute upon violation of the security policy. The generated security policy may be embedded in the document using steganography. Accordingly, transmission of the document may include transmission of the security policy with the document. The document may be transmitted to a destination node. A user at the destination node may request access to the document. In response to the request, the security policy embedded in the document may be executed to confirm whether the user is an authorized user. If the user is authorized, access to the document may be enabled. If the user is not authorized, the one or more response actions may be executed.

Abstract: A wireless transceiver for a wireless communication network has an offset Gregorian antenna arrangement comprising a primary reflector dish, an electrically conductive reflector member comprising a secondary reflector and a conductive support wall, a planar array of antenna elements arranged as a feed for transmitting radio frequency signals to the secondary reflector and/or for receiving radio frequency signals from the secondary reflector and a conductive support block configured to support the planar array of antenna elements. The conductive support wall is connected directly to the conductive support block, and the conductive support wall is configured to be substantially perpendicular to the planar array of antenna elements.

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

Abstract: The present disclosure provides methods and compositions for detecting polynucleotides in a sample and for quantifying polynucleotide load in a sample. The polynucleotides can be associated with a disease, disorder, or condition. In some applications, methylated DNA is quantified, e.g., in order to determine the load of polynucleotides in a sample. The present disclosure also provides methods and compositions for determining the load of fetal polynucleotides in a biological sample, e.g., the load of fetal polynucleotides (e.g., DNA, RNA) in maternal plasma. The present disclosure provides methods and compositions for detecting cellular processes such as cellular viability, growth rates, and infection rates. This disclosure also provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some embodiments, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g.

Abstract: There is disclosed a method for treating an isolated hydrocarbon interval feedable through a production tubing inside a well bore and forming an annulus therebetween. A perforated cylindrical tool having an expandable annular seal may attach to the production tubing and house a slidable element positionally responsive to an injection velocity of a well fluid. The tool may be lowered to a sealing depth for bracketing the hydrocarbon interval. Injection of the well fluid may drag a narrowing bore of the slidable element downward for expanding the annular seal against the well bore. The well fluid may also be directed from the element bore to the annulus by aligning an element flow port with a corresponding tool passage, a downstream or an upstream flow being selectable by an injection velocity for slidably aligning the corresponding flow ports having different axial locations.

Abstract: Disclosed is a system for qualifying medical images submitted by user for diagnostic analysis comprising: an image input module, configured to receive one or more image input by a user; an image protocol conformation module, configured to receive the one or more images from the image input module, and further configured to analyze each of the one or more images for conformity with a predefined protocol and wherein images that do not conform to the predefined protocol are flagged as non-conforming images; an image output module, configured to identify to the user each of the one or more images flagged as non-conforming and prompting the user to resubmit a new image for each of the non-conforming images; and an image resubmission module, configured to receive the user resubmitted image and provide the resubmitted image to the image protocol conformation module.

Abstract: A protective garment for providing improved safety and customization of personal protective equipment (PPE), and in particular, for welding protection from wire-sticks from exposed welding wires during welding. The protective garment includes a heat conducting composite made of one or more layers of a heat conducting material and one or more layers of a binder. The one or more heat conducting material layers may be a carbon fiber layer, such as a woven carbon-fiber layer, and the one or more binders may be an elastomeric binder, such as a polymer. As such, the heat conducting composite may be a carbon fiber reinforced polymer (CFRP) in which the elastomeric binder is used to hold the woven fibers and/or layers together. The heat conducting composite material may be used to form PPE, it may be formed into guards for use over PPE, or as an insert for use under PPE.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: A luminaire includes a housing defining an interior volume. The luminaire also includes a lamp within the interior volume and configured to emit light. Additionally, the luminaire includes a wireless antenna positioned within the interior volume, configured to transmit or receive a wireless signal along a first direction, and configured to be operatively coupled to an access point. The wireless antenna can be entirely within the interior volume. The luminaire can include a first reflective surface within the interior volume and configured to redirect the wireless signal. The lamp can be configured to be electrically coupled to a power inserter that powers the access point.

Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: A novel adhesion layer of hafnium nitride useful in the fabrication of semiconductor devices is disclosed. In particular, semiconductor devices such as, for example, thin film transistors which include one or more elements formed of metals with high electron concentrations, such as molybdenum, tungsten, nickel, ruthenium, cobalt and alloys thereof, can employ the present invention to better adhere the metal elements to the dielectric material on which the semiconductor devices are formed and the adhesion layer can also serve as a diffusion barrier.

Abstract: The present invention relates to compositions and methods for forming substantially bio-based barrier coatings suitable for application on paper and board substrates, and paper and board substrates on which are applied one or more layers of such substantially bio-based barrier coatings. The inventive bio-based barrier coatings comprise a biowax emulsion comprising one or more biowaxes, such as castor oil wax, formed by hydrogenation of a bio-based oil, such as castor oil. The barrier coating composition is formed by dispersing a biowax emulsion into a polyhydroxyalkanoate (PHA) dispersion, and may be applied as a coating e.g., on paper or board, e.g., those comprised of recycled fibers, using conventional industrial methods at ambient temperatures.

Abstract: Methods and compositions for making DNA libraries for massive parallel next generation sequencing (NGS), comprises two parts. These methods may be referred to as Triseq sequencing. The first part includes ligating a UMI adapter, amplifying the DNA fragments in the presence of dUTP, enriching the target molecules through primer extension by using a panel of both forward and reverse primers, and removing the dU-containing template DNA. The DNA molecules are organized to primary clones and subclones, labeled by the UMI on 5? and 3? end of the DNA fragments, respectively. The second part includes sequencing the DNA library by NGS, deducing consensus sequence from each subclone, and from within each primary clone, and between the consensus sequences obtained from both forward and reverse primers.

Abstract: A system and method for facilitating annotation of a digital document between first and second computing devices is provided. The system comprises a database/server that receives an original digital document from the first computing device and communicates a shared digital document to the second computing device. The second computing device receives and displays the shared digital document for annotation. The annotation produces an annotated digital document which includes annotated document data overlaying the original document without modification to the original document data. The original digital document may be edited at only the first computing device.

Abstract: An adjustable spa frame may include a frame member configured to interface with a sliding frame, the sliding frame configured to be adjusted relative to the frame member to secure the sliding frame at a first position or a second position relative to the frame member. The adjustable spa frame has a first length when the sliding frame is in the first position and the adjustable spa frame has a second length different than the first length when the sliding frame is in the second position.

Abstract: There is provided a transgenic insect comprising a heterologous nucleic acid encoding a fungal laccase wherein the heterologous nucleic acid is integrated in the insect genome, wherein the heterologous nucleic acid is operably linked to a promoter, and expression of the laccase allows for production of an active fungal laccase in the insect. The insect or laccase preparations comprising meal or powder made from the insect are used to reduce or remove phenolic contaminants (such as BPA) or aromatic components (such as indigo dyes) from waste.

Abstract: A method includes converting, by a generative network, an input into a latent vector representation of a sample chemical compound, wherein the input is one of an order-dependent representation of the sample chemical compound and a molecular graph representation of the sample chemical compound; determining, by an output neural network, one or more properties of the sample chemical compound based on the latent vector representation of the sample chemical compound; performing, by the output neural network, an optimization routine to select a candidate latent vector representation from among a plurality of latent vector representations based on the latent vector representation of the sample chemical compound, wherein the plurality of latent vector representations includes the latent vector representation of the sample chemical compound; and identifying, by the output neural network, a candidate chemical compound based on the candidate latent vector representation.

Abstract: Methods and compositions for making DNA libraries for massive parallel next generation sequencing (NGS), comprises two parts. These methods may be referred to as Triseq sequencing. The first part includes ligating a UMI adapter, amplifying the DNA fragments in the presence of dUTP, enriching the target molecules through primer extension by using a panel of both forward and reverse primers, and removing the dU-containing template DNA. The DNA molecules are organized to primary clones and subclones, labeled by the UMI on 5? and 3? end of the DNA fragments, respectively. The second part includes sequencing the DNA library by NGS, deducing consensus sequence from each subclone, and from within each primary clone, and between the consensus sequences obtained from both forward and reverse primers.