Abstract: A protective garment for providing improved safety and customization of personal protective equipment (PPE), and in particular, for welding protection from wire-sticks from exposed welding wires during welding. The protective garment includes a heat conducting composite made of one or more layers of a heat conducting material and one or more layers of a binder. The one or more heat conducting material layers may be a carbon fiber layer, such as a woven carbon-fiber layer, and the one or more binders may be an elastomeric binder, such as a polymer. As such, the heat conducting composite may be a carbon fiber reinforced polymer (CFRP) in which the elastomeric binder is used to hold the woven fibers and/or layers together. The heat conducting composite material may be used to form PPE, it may be formed into guards for use over PPE, or as an insert for use under PPE.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: A luminaire includes a housing defining an interior volume. The luminaire also includes a lamp within the interior volume and configured to emit light. Additionally, the luminaire includes a wireless antenna positioned within the interior volume, configured to transmit or receive a wireless signal along a first direction, and configured to be operatively coupled to an access point. The wireless antenna can be entirely within the interior volume. The luminaire can include a first reflective surface within the interior volume and configured to redirect the wireless signal. The lamp can be configured to be electrically coupled to a power inserter that powers the access point.

Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: A novel adhesion layer of hafnium nitride useful in the fabrication of semiconductor devices is disclosed. In particular, semiconductor devices such as, for example, thin film transistors which include one or more elements formed of metals with high electron concentrations, such as molybdenum, tungsten, nickel, ruthenium, cobalt and alloys thereof, can employ the present invention to better adhere the metal elements to the dielectric material on which the semiconductor devices are formed and the adhesion layer can also serve as a diffusion barrier.

Abstract: The present invention relates to compositions and methods for forming substantially bio-based barrier coatings suitable for application on paper and board substrates, and paper and board substrates on which are applied one or more layers of such substantially bio-based barrier coatings. The inventive bio-based barrier coatings comprise a biowax emulsion comprising one or more biowaxes, such as castor oil wax, formed by hydrogenation of a bio-based oil, such as castor oil. The barrier coating composition is formed by dispersing a biowax emulsion into a polyhydroxyalkanoate (PHA) dispersion, and may be applied as a coating e.g., on paper or board, e.g., those comprised of recycled fibers, using conventional industrial methods at ambient temperatures.

Abstract: Methods and compositions for making DNA libraries for massive parallel next generation sequencing (NGS), comprises two parts. These methods may be referred to as Triseq sequencing. The first part includes ligating a UMI adapter, amplifying the DNA fragments in the presence of dUTP, enriching the target molecules through primer extension by using a panel of both forward and reverse primers, and removing the dU-containing template DNA. The DNA molecules are organized to primary clones and subclones, labeled by the UMI on 5? and 3? end of the DNA fragments, respectively. The second part includes sequencing the DNA library by NGS, deducing consensus sequence from each subclone, and from within each primary clone, and between the consensus sequences obtained from both forward and reverse primers.

Abstract: A system and method for facilitating annotation of a digital document between first and second computing devices is provided. The system comprises a database/server that receives an original digital document from the first computing device and communicates a shared digital document to the second computing device. The second computing device receives and displays the shared digital document for annotation. The annotation produces an annotated digital document which includes annotated document data overlaying the original document without modification to the original document data. The original digital document may be edited at only the first computing device.

Abstract: An adjustable spa frame may include a frame member configured to interface with a sliding frame, the sliding frame configured to be adjusted relative to the frame member to secure the sliding frame at a first position or a second position relative to the frame member. The adjustable spa frame has a first length when the sliding frame is in the first position and the adjustable spa frame has a second length different than the first length when the sliding frame is in the second position.

Abstract: There is provided a transgenic insect comprising a heterologous nucleic acid encoding a fungal laccase wherein the heterologous nucleic acid is integrated in the insect genome, wherein the heterologous nucleic acid is operably linked to a promoter, and expression of the laccase allows for production of an active fungal laccase in the insect. The insect or laccase preparations comprising meal or powder made from the insect are used to reduce or remove phenolic contaminants (such as BPA) or aromatic components (such as indigo dyes) from waste.

Abstract: A method includes converting, by a generative network, an input into a latent vector representation of a sample chemical compound, wherein the input is one of an order-dependent representation of the sample chemical compound and a molecular graph representation of the sample chemical compound; determining, by an output neural network, one or more properties of the sample chemical compound based on the latent vector representation of the sample chemical compound; performing, by the output neural network, an optimization routine to select a candidate latent vector representation from among a plurality of latent vector representations based on the latent vector representation of the sample chemical compound, wherein the plurality of latent vector representations includes the latent vector representation of the sample chemical compound; and identifying, by the output neural network, a candidate chemical compound based on the candidate latent vector representation.

Abstract: Methods and compositions for making DNA libraries for massive parallel next generation sequencing (NGS), comprises two parts. These methods may be referred to as Triseq sequencing. The first part includes ligating a UMI adapter, amplifying the DNA fragments in the presence of dUTP, enriching the target molecules through primer extension by using a panel of both forward and reverse primers, and removing the dU-containing template DNA. The DNA molecules are organized to primary clones and subclones, labeled by the UMI on 5? and 3? end of the DNA fragments, respectively. The second part includes sequencing the DNA library by NGS, deducing consensus sequence from each subclone, and from within each primary clone, and between the consensus sequences obtained from both forward and reverse primers.

Abstract: A compensating fastener assembly is configured to secure a fastener to a surface element. The compensating fastener assembly includes a compression limiter having a cylindrical main body and a flange, the cylindrical main body defining a channel and a longitudinal axis. The compensating fastener assembly further includes a spring defining a central passage. The central passage of the spring is configured to receive the main body of the compression limiter such that a first end of the spring is configured to be disposed adjacent the flange of the compression limiter.

Abstract: Embodiments described herein provide a computer-implemented method for predicting reaction constituents, comprising: generating a catalyst or solvent efficacy score based on reaction data; storing a graph convolutional model, generated based on the reaction data and the catalyst/solvent efficacy scores: wherein for a catalyst, graph representations of the catalyst and of a reactant and a product are inputs to the graph convolutional model; and similarly for a solvent; predicting the effectiveness of a specified catalyst/solvent based on a specified reaction definition and/or predicting a catalyst/solvent by determining whether the first and second reactions have an identical core transform.

Abstract: Compositions, systems, kits, and methods are described herein for the modulation, and in particular the reduction or inhibition, of expression of the FLCN gene or the activity of FLCN protein in a cell, animal, or human subject. Compositions, systems, and methods disclosed herein can be used to prevent, ameliorate, or treat diseases, particularly neuromuscular or neurodegenerative diseases, retinal degeneration diseases, or other TDP-43 proteinopathies. Methods are described for the modulation, and in particular the reduction or inhibition of FLCN expression or activity, comprising the use of a modulator to regulate FLCN expression or activity. Methods are also described for the development, synthesis, and production of modulators, and for therapeutic treatment of TDP-43 proteinopathies such as ALS and other related disorders.

Abstract: The Multidimensional Machine Learning Data and User Interface Segment Tagging Engine Apparatuses, Methods and Systems (“MLUI”) transforms ambient condition data, sales data, user interface selections, cognitive intelligence question input inputs via MLUI components into project projections, campaigns, user interface visualizations, cognitive intelligence question output outputs. An update to a survey data file is detected. The updated survey data is stored in a SQL database configured to utilize a composite index of the updated survey data that optimizes database query time. A set of affected entity segment identifiers is determined. A set of affected category identifiers is determined. A set of affected cognitive intelligence (CI) datapoint identifiers is determined as CI datapoint identifiers associated with each combination of an affected entity segment identifier and an affected category identifier.

Abstract: The Multidimensional Machine Learning Data and User Interface Segment Tagging Engine Apparatuses, Methods and Systems (“MLUI”) transforms ambient condition data, sales data, user interface selections, cognitive intelligence question input inputs via MLUI components into project projections, campaigns, user interface visualizations, cognitive intelligence question output outputs. A category identifier selection is obtained via a category selection interaction interface mechanism. Entity segment identifier selections are obtained via entity segment selection interaction interface mechanisms. A set of visualization cognitive intelligence (CI) datapoint identifiers is determined as CI datapoint identifiers associated with each combination of a selected entity segment identifier and the selected category identifier.

Abstract: The present disclosure is directed to compounds of formula (I): wherein R1, R2, R3, R3a, R4, Y, and X are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

Abstract: Methods, apparatuses and compositions for generating highly sensitive and accurate sequencing results of massive parallel sequencing (NGS). The methods and compositions may be referred to as SubDivision-Seq, and may comprise two parts. The first part includes making a target-enriched DNA library, organizing the UMIs on DNA molecules to form primary clones and subdividing the primary clones into subclones. The second part includes sequencing the DNA library by NGS, deducing consensus sequence from each subclone, then deducing consensus sequence in each primary clone.

Abstract: In embodiments, an authentication server interfaces between a user device with a self-signed certificate and a verifying computer that accepts a user name and password. The user device generates a self-signed certificate signed by a private key on the user device. The self-signed certificate is transmitted to a verifying party computer over a network. The verifying party stores the self-signed certificate with user identification data. The user migrates trust to another device by providing the root certificate and intermediate certificate as a certificate chain to a second device, which then adds a new intermediate certificate to create a longer certificate chain with the same root certificate. In subsequent communications, the verifying party receives a certificate chain including the self-signed certificate from the second user device, and matches that with the user identification data stored in a database.