Abstract: Compounds of Formula (I) and Formula (II), which are capable of binding to granzyme B. Also provided herein are pharmaceutical compositions comprising such for use in, for example, imaging Granzyme B and/or treating immunoregulatory abnormalities.

Abstract: The present disclosure relates to various different types of mutations in the thrA gene in E. coli leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

Abstract: The application provides a light expander/contractor device and method of using same, the light expander/contractor device comprising: a faceted quartz structure comprising a lateral surface communicating with a light processing surface at one end and communicating with a planar surface at an opposed end; the light processing surface comprising an initial surface extending from the lateral surface substantially parallel to the planar surface and having a distal end spaced from the lateral surface, the light processing surface further comprising multiple levels of facets comprising quartz-air interfaces: each level of facets comprising (a) a proximal facet surface relative to the lateral surface, the proximal facet surface extending away from the initial surface and toward the lateral surface at a 45° angle relative to the initial surface to communicate with (b) a facet planar surface spaced apart from and parallel to the initial surface to communicate with (c) a distal facet surface adjacent and substantially

Abstract: The present disclosure relates to various different types of mutations in the thrA gene in E. coli leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

Abstract: Genetically-modified cell capable of producing UD CA, cholic acid, and/or another UDCA precursor comprising at least one heterologous polynucleotide encoding an enzyme involved in a metabolic pathway that converts sugar to UDCA, cholic acid, and/or another UDCA precursor. Method of making UDCA, cholic acid, and/or another UDCA precursor using such a cell. Use of UDCA or UDCA precursor produced using such a method for the manufacture of a medicament for the treatment of a disease or symptom of a disease. Medicament comprising UDCA or UDCA precursor made using such a method. Method of treating a disease or symptom of a disease comprising administering UDCA or a UDCA precursor made using such a method. Isolated nucleic acid encoding at least one enzyme involved in a metabolic pathway that converts sugar to UDCA, cholic acid, and/or another UDCA precursor.

Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

Abstract: Systems and methods for recording and communicating engine data are provided. One example aspect of the present disclosure is directed to a method for monitoring performance. The method includes receiving, by one or more computing devices, a measurement from a sensor. The method includes assigning, by the one or more computing devices, a time to the measurement. The method includes storing, by the one or more computing devices, the received measurement and the assigned time to a file. The method includes transmitting, by the one or more computing devices, the file to a remove computing device associated with a ground system.

Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

Abstract: Systems and methods for recording and communicating engine data are provided. One example aspect of the present disclosure is directed to a method for communicating engine data. The method includes receiving data. The method includes separating the data into categories. For one or more categories, the method includes creating a file including the separated data. For one or more categories, the method includes naming the file, at least in part, based on the category and based on a file naming convention. The method includes prioritizing the created files. The method includes transmitting an identification file comprising identification information for a wireless communication unit and the file naming convention. The method includes transmitting the created files based on the priority.

Abstract: The present disclosure relates to various different types of mutations in S. cerevisiae leading to enhanced tyrosine production for, e.g., supplements and nutraceuticals.

Abstract: A method of choosing and authorising a transaction with a payment device used by a purchaser under the authority of an owner is described. An analytics engine receives an identifier for a good or service from the purchaser and uses the identifier to identify providers of the good or service and providing a set of provider recommendations for the good or service to the owner. An issuer server receives from the owner approval for one of the set of provider recommendations and determining purchase parameters for that provider recommendation and determines whether the purchase parameters for the transaction match the purchase parameters for the provider recommendation; whereby the transaction is not authorised if the purchase parameters do not match and will not be rejected by the payment control system if the parameters do match.

Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

Abstract: In one embodiment, the application provides a photon engine comprising one or more cylinders comprising: a primary prism and a secondary prism which may or may not comprise a linear switch, the primary prism comprising one or more light beam inlets and multiple internal faces comprising a primary back face, the secondary prism comprising multiple lateral faces and having a secondary back face positioned adjacent to and spaced apart from the primary back face, forming a non-transparent interface between the primary prism and the secondary prism; the primary prism comprising a light expander/contractor device communicating with the light beam inlet, the light expander/contractor device comprising facets adapted to produce a processed light beam by expanding the diameter of a light beam entering from a given direction; an optic switch comprising a piezoelectric actuator operatively coupled with the primary prism and/or the secondary prism and adapted to (a) compress the secondary back face relative to the primar

Abstract: Systems and methods for recording and communicating engine data are provided. One example embodiment is directed to a system for testing communications. The system includes an electronic engine controller. The system includes a wireless communication unit in communication with the electronic engine controller. The wireless communication unit includes one or more memory devices. The wireless communication unit includes one or more processors. The one or more processors are configured to provide a resource to a remote computing device. The one or more processors are configured to receive input from the remote computing device via the resource. The one or more processors are configured to cause a connectivity test to be performed in response to the received input. The one or more processors are configured to transmit a result of the connectivity test to the remote computing device.

Abstract: Systems and methods for recording and communicating engine data are provided. One example aspect of the present disclosure is directed to a method for key management. The method includes generating a pair of keys, wherein one of the pair of keys is a private key, and wherein one of the pair of keys is a public key. The method includes transmitting the public key to a first remote computing device, wherein the first remote computing device transmits the public key to a second remote computing device. The method includes receiving a host key from the first remote computing device, wherein the first remote computing device received the host key from the second remote computing device. The method includes accessing the second remote computing device using the private key. The method includes verifying a request from the second remote computing device using the host key.

Abstract: Systems and methods for recording and communicating engine data are provided. One example embodiment is directed to a method for communicating engine data to a ground system. The method includes receiving a request to store first data in a first memory location in one or more memory devices. The method includes receiving the first data, wherein the first data is associated with identification of an engine, and wherein the first data includes parameterized data. The method includes storing the first data in the first memory location. The method includes receiving a request to store second data in a second memory location in the one or more memory devices, wherein the second memory location is reserved for data to be transmitted to the ground system. The method includes receiving the second data. The method includes storing the second data in the second memory location.

Abstract: A computer-based method for throttling payment card transaction processing is provided. The method uses a computer device including a processor and a memory. The method includes identifying, in the memory, a first threshold level. The method also includes transmitting a first plurality of transaction requests to a sub-processing system. The method further includes computing, by the processor, an average response time of the sub-processing system for processing the first plurality of transaction requests. The method also includes receiving a second plurality of transaction requests. The method further includes identifying one or more of the second plurality of transaction requests as failure candidates based at least in part on the average response time and the first threshold level. The method also includes failing one or more of the failure candidates.

Abstract: Systems and methods for recording and communicating engine data are provided. One example aspect of the present disclosure is directed to a method for maintaining a wireless communication unit. The method includes transmitting, by one or more computing devices, an identification file to one or more second computing devices associated with a ground system. The method includes automatically retrieving, by the one or more computing devices, a loadable software aircraft part for data load from the one or more second computing devices associated with the ground system. The method includes performing, by the one or more computing devices, a data load using the loadable software aircraft part. The method includes determining, by the one or more computing devices, if the data load was successful. The method includes transmitting, by the one or more computing devices, the determination to the one or more computing devices associated with the ground system.